A pyrene-based fluorescent probe for HS detection and cellular imaging.

Hydrogen sulfide (HS) is a significant reactive sulfur species (RSS) involved in various human diseases, also playing an important role in many physiological and pathological processes. Thus, the development of an effective method for detecting HS in mammalian cells is of great importance. In this study, we present the synthesis of a novel pyrene-based fluorescent probe, DPP, specifically designed for the selective detection of HS.

Late Gadolinium Enhancement of Nonischemic Cardiomyopathy at 5.0 T versus 3.0 T: A Crossover Design Study.

Purpose To compare the acquisition time, image quality, and late gadolinium enhancement (LGE) visualization and quantification on phase-sensitive inversion recovery (PSIR) images using 5.0-T versus 3.0-T cardiac MRI.

Simultaneous multislice cardiac multimapping based on locally low-rank and sparsity constraints.

Background: Although quantitative myocardial T1 and T2 mappings are clinically used to evaluate myocardial diseases, their application needs a minimum of six breath-holds to cover three short-axis slices. The purpose of this work is to simultaneously quantify multislice myocardial T1 and T2 across three short-axis slices in one breath-hold by combining simultaneous multislice (SMS) with multimapping.

Methods: An SMS-Multimapping sequence with multiband radiofrequency (RF) excitations and Cartesian fast low-angle shot readouts was developed for data acquisition.

Robust Fast Inter-Bin Image Registration for Undersampled Coronary MRI Based on a Learned Motion Prior.

Objective: To propose a 3D nonrigid registration method that accurately estimates the 3D displacement field from artifact-corrupted Coronary Magnetic Resonance Angiography (CMRA) images.

Methods: We developed a novel registration framework for registration of artifact-corrupted images based on a 3D U-Net initializer and a deep unrolling network. By leveraging a supervised learning framework with training labels estimated from fully-sampled images, the unrolling network learns a task-specific motion prior which reduces motion estimation biases caused by undersampling artifacts in the source images.

A purine fluorescent derived probe assay for glyphosate and mesotrione via Schiff base cleavage.

A fluorescent probe derived from purine with Schiff base moiety was developed for the recognization of glyphosate and mesotrione. The detected glyphosate and mesotrione can lead to the dissociation of the Schiff base probe to enhance the fluorescence via a turn-off PET process. Mechanism study revealed that the synergistic effect of the phosphoric acid and the secondary amine moieties in glyphosate results in the bond cleavage of the Schiff base probe.

Hybrid Molecular Sieve-Based Interfacial Layer with Physical Confinement and Desolvation Effect for Dendrite-free Zinc Metal Anodes.

The side reactions and dendrite growth at the interface of Zn anodes greatly limit their practical applications in Zn metal batteries. Herein, we propose a hybrid molecular sieve-based interfacial layer (denoted as ZM) with a hierarchical porous structure for Zn metal anodes, which contains 70 vol % microporous ZSM-5 molecular sieves and 30 vol % mesoporous MCM-41 molecular sieves. Through comprehensive molecular dynamics simulations, we demonstrate that the mesopores (∼2.

Antibiotic Resistance Profiles and MLST Typing of Clone Associated with Skin and Soft Tissue Infections in a Hospital of China.

Objective: To analyze the antibiotic resistance profile, virulence genes, and molecular typing of () strains isolated in skin and soft tissue infections at the First Affiliated Hospital, Gannan Medical University, to better understand the molecular epidemiological characteristics of .

Methods: In 2023, 65 strains were isolated from patients with skin and soft tissue infections. Strain identification and susceptibility tests were performed using VITEK 2 and gram-positive bacteria identification cards.

Three-in-One Zinc Anodes Created by a Large-scale Two-Step Method Achieving Excellent Long-Term Cyclic Reversibility and Thin Electrode Integrity.

Practical aqueous zinc-ion batteries require low-cost thin zinc anodes with long-term reversible stripping/depositing. However, thin zinc anodes encounter more severe issues than thick zinc, such as dendrites and uneven stripping, resulting in subpar performance and limited lifetimes. Here, this work proposes a three-in-one zinc anode obtained by a large-scale two-step method to address the above issues.

Sensitive fluorescence detection of glyphosate and glufosinate ammonium pesticides by purine-hydrazone-Cu complex.

Organophosphorus pesticides play an important role as broad-spectrum inactivating herbicides in agriculture. Developing a method for rapid and efficient organophosphorus pesticides detection is still urgent due to the increasing concern on food safety. An organo-probe (ZDA), synthesized by purine hydrazone derivative and 2,2'-dipyridylamine derivative, was applied in sensitive recognition of Cu with detection limit of 300 nM.

Oxymatrine Inhibition of Hepatitis B Virus Replication Through ERK1/2 Pathway and HNF1α and HNF4α Block in vitro.

Objective: To explore the molecular mechanism of oxymatrine (OM) by increasing the phosphorylation of ERK1/2 signal factor and blocking the transcription factors HNF1α and HNF4α expression against hepatitis B virus (HBV) antigen secretion and HBV DNA replication in HepG2.2.15 cells.

Electrochemical decarboxylative alkylation of β-ketoacids with phenol derivatives.

An electrochemical method for the decarboxylative alkylation of β-ketoacids with phenol derivatives has been developed. The protocol was carried out in readily available unseparated cells at room temperature in the absence of catalysts and oxidants. The corresponding aryl ketones were obtained in satisfactory yields without additional electrolytes, and were easy to produce in gram-scale synthesis.

Diagnostic performance of 3.0 T unenhanced Dixon water-fat separation coronary MR angiography in patients with low-to-intermediate risk of coronary artery disease.

Purpose: To evaluate the diagnostic performance of 3.0 T unenhanced compressed-sensing sensitivity encoding (CS-SENSE) Dixon water-fat separation coronary MR angiography (CMRA) in patients with low-to-intermediate risk of coronary artery disease (CAD) and its ability to grade the severity of CAD based on Coronary Artery Disease Reporting and Data System (CAD-RADS).

Methods: A total of 55 patients who was clinically evaluated as low-to-intermediate risk of CAD were finally included to undergo both 3.

A purine-based fluorescent probe for HS detection and imaging of cells.

Hydrogen sulfide (HS) is a gas with a toxic odor that plays an irreplaceable role in physiological activities within the mammalian body. Therefore, it is important to do the distribution and quantitative detection of HS in mammalian cells. In this paper, a fluorescence probe (EDPH) based on purine scaffold was designed and synthesized with high sensitivity and good selectivity.

Inorganic Oxide-Based "Hydrophobic-Hydrophilic-Hydrophobic" Separators Systems for Long-Life Zinc-Ion Batteries.

Hydrogen reduction reaction (HER) and corrosion limit the long-life cycle of zinc-ion batteries. However, hydrophilic separators are unable to prevent direct contact between water and electrodes, and hydrophobic separators have difficulty in transporting electrolytes. In this work, an inorganic oxide-based "hydrophobic-hydrophilic-hydrophobic" self-assembled separator system is proposed.

A clinical strategy to improve the diagnostic performance of 3T non-contrast coronary MRA and noninvasively evaluate coronary distensibility: combination of diastole and systole imaging.

Background: The clinical application of coronary MR angiography (MRA) combining diastole and systole imaging has never been described comprehensively in coronary artery disease (CAD) patients. We aimed to design an optimal non-contrast coronary MRA scan protocol combining diastolic and systolic imaging and to (1) evaluate its diagnostic performance for detecting significant coronary stenosis; (2) evaluate the feasibility of this protocol to noninvasively measure the coronary distensibility index (CDI).

Methods: From June 2021 to May 2022, 33 healthy volunteers and 91 suspected CAD patients scheduled for X-ray coronary angiography (CAG) were prospectively enrolled.

Synthesis and application of purine-based fluorescence probe for continuous recognition of Cu and glyphosate.

In this study, a novel fluorescent sensor, N,N-dimethyl-4-((2-(8-m-ethyl-9-(naphthalen-1-yl)-9H-purin-6-yl)hydrazineylidene)methyl)aniline(PHA), which was constructed via Schiff base reaction of purine derivatives and dimethylaminobenzaldehyde. This probe showed significant selective fluorescence quenching of Cu, and accompanying with an increase in Cu concentration and a change in solution color from colorless to yellow. The outstanding features of PHA include low detection limit (0.

The emerging role of extracellular vesicles in fungi: a double-edged sword.

Fungi are eukaryotic microorganisms found in nature, which can invade the human body and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These diseases can severely damage the patient's body systems and functions, leading to a range of clinical symptoms that can be life-threatening. As the incidence of invasive fungal infections has progressively increased in the recent years, a wealth of evidence has confirmed the "double-edged sword" role of fungal extracellular vesicles (EVs) in intercellular communication and pathogen-host interactions.

3.0 T unenhanced Dixon water-fat separation whole-heart coronary magnetic resonance angiography: compressed-sensing sensitivity encoding imaging versus conventional 2D sensitivity encoding imaging.

This study was aimed to investigate 3.0 T unenhanced Dixon water-fat whole-heart CMRA (coronary magnetic resonance angiography) using compressed-sensing sensitivity encoding (CS-SENSE) and conventional sensitivity encoding (SENSE) in vitro and in vivo. The key parameters of CS-SENSE and conventional 1D/2D SENSE were compared in vitro phantom study.

Cancer phototherapy with nano-bacteria biohybrids.

The utilization of light for therapeutic interventions, also known as phototherapy, has been extensively employed in the treatment of a wide range of illnesses, including cancer. Despite the benefits of its non-invasive nature, phototherapy still faces challenges pertaining to the delivery of phototherapeutic agents, phototoxicity, and light delivery. The incorporation of nanomaterials and bacteria in phototherapy has emerged as a promising approach that leverages the unique properties of each component.

Sensing of organophosphorus pesticides by fluorescent complexes based on purine-hydrazone receptor and copper (II) and its application in living-cells imaging.

In this study, we used purine hydrazone derivatives and coumarin aldehyde to synthesize a novel fluorescent sensor (EDTP) by Schiff base reaction, which exhibited significant selective fluorescence quenching of Cu, and a distinct change from brilliant yellow to red is present along with the solution color. The detection limit of EDTP for Cu was 109.52 nM.

Gradient Electrolyte Strategy Achieving Long-Life Zinc Anodes.

Aqueous Zn-ion batteries are plagued by a short lifespan caused by localized dendrites. High-concentration electrolytes are favorable for dense Zn deposition but have poor performance in batteries with glass-fiber separators. In contrast, low-concentration electrolytes can wet the separators well, ensuring the migration of zinc ions, but the dendrites grow rapidly.

Drug Resistance Genes and Molecular Epidemiological Characteristics of Carbapenem-Resistant .

Background: The global prevalence of carbapenem-resistant (CRKP) has become a serious challenge for nosocomial infection and attracted worldwide attention. This study explored the drug resistance genes and molecular characteristics for CRKP, providing a reference for nosocomial prevention and control.

Methods: A total of 42 CRKP isolates were collected from the First Affiliated Hospital of Gannan Medical University (Ganzhou, China) from January 2018 to February 2021.

Bonding Lithium Metal with Garnet Electrolyte by Interfacial Lithiophobicity/Lithiophilicity Transition Mechanism over 380 °C.

Garnet electrolytes, possessing high ionic conductivity (10 -10 S cm at room temperature) and excellent chemical/electrochemical compatibility with lithium metal, are expected to be used in solid-state lithium metal batteries. However, the poor solid-solid interfacial contact between lithium and garnet leads to high interfacial resistance, reducing the battery power capability and cyclability. Garnet electrolytes are commonly believed to be intrinsically lithiophilic, and lithiophobic Li CO on the garnet surface accounted for the poor interfacial contact.

200 MPa cold isostatic pressing creates surface-microcracks in a Zn foil for scalable and long-life zinc anodes.

The Zn anode suffers from severe dendrite growth and side reactions, which restrict its development in the realm of large-scale energy storage. Herein, in this study, we propose a method to create surface-microcracks in a Zn foil by 200 MPa cold isostatic pressing. The proposed pressing method can avoid the surface tip effect of Zn, and creates a subtly surface-microcracked zinc structure, providing more zinc ion transport channels, thereby effectively alleviating the dendrite growth and side reactions during the repeated Zn plating and stripping.