Publications by authors named "Hongfan Yuan"

The MIR663AHG gene encodes both miR663AHG and miR663a. While miR663a contributes to the defense of host cells against inflammation and inhibits colon cancer development, the biological function of lncRNA miR663AHG has not been previously reported. In this study, the subcellular localization of lncRNA miR663AHG was determined by RNA-FISH.

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Article Synopsis
  • Kaiso, a transcription factor linked to tumor suppression, interacts with P120ctn and translocates from the nucleus to the cytoplasm when phosphorylated at T606 by AKT1.
  • Phosphorylated Kaiso (pT606-Kaiso) binds to 14-3-3 proteins, which are essential for its cytoplasmic accumulation and activation of the CDH1 gene, a known tumor suppressor.
  • Research indicates that reduced levels of pT606-Kaiso and CDH1 are common in human gastric cancer, suggesting impaired Kaiso phosphorylation may play a role in cancer development and progression.
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WTAP, an essential component of the RNA N-6-methyladenosine (m6A) modification complex, guides METLL3-METLL14 heteroduplexes to target RNAs in the nuclear speckles of mammalian cells. Here, we show that TTC22 is widely coexpressed with WTAP and FTO in many human tissues by mining Genotype-Tissue Expression (GTEx) datasets. Our results indicate that the direct interaction of TTC22 with 60S ribosomal protein L4 (RPL4) promotes the binding of WTAP mRNA to RPL4, enhances the stability and translation efficiency of WTAP mRNA, and consequently increases the level of WTAP protein.

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Background: Recently, emerging evidence has indicated crucial roles for long noncoding RNAs (lncRNAs) in breast cancer (BC) development and progression. Our study aimed to investigate the clinical significance of LINC01089 in patients with BC and to determine its biological functions and underlying molecular mechanisms.

Materials And Methods: Correlations between LINC01089 expression and the clinicopathological characteristics of BC patients were assessed using chi-square tests.

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The abnormal expression of microRNAs is a key hallmark of breast cancer. Nevertheless, the biological roles of miR-1247-5p in breast cancer remain unknown. In this study, we revealed that miR-1247-5p expression was markedly decreased in breast cancer.

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