Bidirectional transcription of mammalian mitochondrial DNA generates overlapping transcripts that are capable of forming double-stranded RNA (dsRNA) structures. Release of mitochondrial dsRNA into the cytosol activates the dsRNA-sensing immune signaling, which is a defense mechanism against microbial and viral attack and possibly cancer, but could cause autoimmune diseases when unchecked. A better understanding of the process is vital in therapeutic application of this defense mechanism and treatment of cognate human diseases.
View Article and Find Full Text PDFOne of the basic questions in the aging field is whether there is a fundamental difference between the aging of lower invertebrates and mammals. A major difference between the lower invertebrates and mammals is the abundancy of noncoding RNAs, most of which are not conserved. We have previously identified a noncoding RNA Terc-53 that is derived from the RNA component of telomerase Terc.
View Article and Find Full Text PDFSpecies of the genus displayed crucial morphological characteristics of vertebrates transitioning from aquatic to terrestrial habitats; thus, they can be regarded as a representative vertebrate genus for this landing phenomenon. But the present phylogenetic status of has been controversial with morphological and molecular approaches, and specific gene rearrangements were discovered in all six published mitogenomes, which are rarely observed in Archaeobatrachia. Therefore, this study determined the complete mitogenome of .
View Article and Find Full Text PDFThe mitochondrial genome (mitogenome) sequence of the tree frog (16,473 bp) was previously reported as having the unusual characteristic of lacking the ND5 gene. In this study, a new mitogenome of (19,952 bp) was resequenced using the next-generation sequencing (NGS) and standard Sanger sequencing technologies. It was discovered that the ND5 gene was not lost but translocated to the control region (CR) from its canonical location between the ND4 and ND6 genes.
View Article and Find Full Text PDFMitochondrial DNA B Resour
July 2019
We obtained the complete mitochondrial genome of , which was 17,785 bp in length and it contained the 37 typical mitochondrial genes: 2 ribosomal RNAs, 22 transfer RNAs (tRNAs), 13 protein-coding genes (PCGs), and 1 control region (CR). The hotspot of gene arrangement was ranged as 'W-gap-O-gap-A-N-gap-C-Y' which consisted with most published mitogenomes. Our phylogenetic results suggested the gene arrangement of 'WANCY' region can facilitate to distinguish the species as an efficient genetic marker.
View Article and Find Full Text PDFMitochondrial DNA B Resour
July 2019
The complete mitogenome of (16,673 bp in length) is determined and analyzed in this study. It contains 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, and one non-coding regions. All the genes in are distributed on the H-strand, except for the gene and seven tRNA genes which are encoded on the L-strand.
View Article and Find Full Text PDFis the only living representative species of Platysternidae and only three subspecies remain: , , and . However, previous reports implied that . .
View Article and Find Full Text PDFBamboo-eating giant panda () is an enigmatic species, which possesses a carnivore-like short and simple gastrointestinal tract (GIT). Despite the remarkable studies on giant panda, its diet adaptability status continues to be a matter of debate. To resolve this puzzle, we investigated the functional potential of the giant panda gut microbiome using shotgun metagenomic sequencing of fecal samples.
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