Publications by authors named "Hongcheng Shi"
Purpose: To investigate the predictive value of 2-[18F]-fluoro-2-deoxy-D-glucose ([F]FDG) PET/CT for evaluating primary tumor (PT) and lymph node (LN) responses after neoadjuvant programmed death-ligand 1 (PD-L1) blockade monotherapy in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC).
Methods: In the single-arm phase 1b NATION-1907 trial (NCT04215471), 23 patients with LA-ESCC received two cycles of neoadjuvant PD-L1 blockade Adebrelimab followed by surgery. Among these, 18 patients underwent [F]FDG PET/CT scans both before immunotherapy and prior to surgery.
Aim: Given that claudin 18.2 (CLDN18.2) is a cell surface protein specifically expressed by gastric cancer cells, anti-CLDN18.
View Article and Find Full Text PDFResting-state functional magnetic resonance imaging (rs-fMRI) and brain functional connectome (we use 'brain connectome' hereafter for simplicity) have advanced our understanding of the ageing brain and age-related changes in cognitive function. Previous studies have investigated the association among brain connectome and age, global cognition, and memory function separately. However, very few have predicted age, overall cognitive functioning and memory performance in a single study to better understand their complex relationship.
View Article and Find Full Text PDFExpert consensus on workflow of PET/CT with long axial field-of-view.
Eur J Nucl Med Mol Imaging
November 2024
Purpose: Positron emission tomography/computed tomography (PET/CT) imaging has been widely used in clinical practice. Long axial field-of-view (LAFOV) systems have enhanced clinical practice by leveraging their technological advantages and have emerged as the new state-of-the-art PET imaging modalities. A consensus was conducted to explore expert views in this emerging field to comprehensively elucidate the proposed workflow in LAFOV PET/CT examinations and highlight the potential challenges inherent in the workflow.
View Article and Find Full Text PDFImportance: Radioactive iodine (131I or RAI) therapy has long been the standard of care for most patients with differentiated thyroid cancer (DTC) after primary surgery. However, no multicenter prospective studies have identified the optimal administered activity and stimulation method for RAI therapy in patients with intermediate-risk DTC.
Objective: To compare the efficacy and safety of recombinant human thyrotropin (SNA001) with thyroid hormone withdrawal (THW) plus 3.
Fibroblast activation protein inhibitor (FAPI) and [F]fluorodeoxyglucose ([F]FDG) provide complementary biological information, and FAPI/FDG dual-tracer imaging clinical application is increasing recently. However, optimal protocols for FAPI/FDG dual-tracer positron emission tomography/computed tomography (PET/CT) and PET/magnetic resonance (PET/MR) imaging are still under investigation. Due to its high sensitivity, total-body PET/CT allows for imaging with minimal tracer activity and supports the creation of new dual-tracer PET/CT imaging protocols.
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- The study aimed to assess the viability of using ultra-low doses of 18F-FDG for total-body PET/CT imaging in pediatric patients and to find the best acquisition times.
- A total of 38 children participated, and data was collected at various time points, which helped evaluate image quality through subjective ratings and quantitative metrics.
- Results indicated that good image quality was achieved even with an 8-minute acquisition time, confirming that such imaging can be safe and effective for children, minimizing their radiation exposure.
Background: Clinical application of the tracer net influx rate (Ki) imaging in PET/CT remains limited, due to a lack of evidence demonstrating the superiority of Ki images in lesion detection, and guidelines on when to utilize Ki images. This study aims to compare the benefits of Ki and standardized uptake value (SUV) images in lesion detection during PET/CT imaging. By analyzing the performance of both techniques in identifying tumor lesions, the study seeks to provide guidance for the clinical application of Ki images.
View Article and Find Full Text PDF[Ga]Ga-RM2 is a novel gastrin-releasing peptide receptor antagonist with emerging diagnostic utility in low-grade breast cancer (BC) expressing estrogen receptors (ER). This systematic review and meta-analysis evaluates the current diagnostic utility of [Ga]Ga-RM2 PET/CT and explores BC tumor uptake metrics in ER-positive BC lesions. A systematic search of PubMed, Scopus, and Web of Science databases was conducted using relevant keywords to extract, screen, and select eligible data for analysis.
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- The study aimed to assess the feasibility and effectiveness of a one-stop dual-tracer PET/CT imaging method using [F]FDG and [Ga]Ga-FAPI-04 for cancer evaluation at a short interval post-injection.
- The results showed that the one-stop imaging method provided higher tumor-to-normal ratios (TNRs) compared to the traditional two-day protocol, with better lesion detectability and reduced radiation exposure.
- Overall, one-stop FDG-FAPI PET/CT could offer sufficient diagnostic information for clinical use and is a promising alternative to longer imaging protocols.
Article Synopsis
- This study reviews the effectiveness of PET/MRI in diagnosing head and neck squamous cell carcinoma (HNSCC) by analyzing various research findings.
- A systematic search identified 15 relevant studies with a total of 638 patients, focusing on the diagnostic accuracy of PET/MRI for different types of HNSCC.
- The analysis showed high sensitivity and specificity for PET/MRI in detecting primary, locoregional, and nodal cancers, suggesting it may be more accurate than other imaging methods, though the difference was not statistically significant.
Article Synopsis
- Researchers developed new insecticides based on the natural compound honokiol, creating novel versions with a specific chemical structure (2-aminobenzoxazole) that were tested against two major agricultural pests.
- The new compounds showed much stronger larvicidal and antifeedant effects than honokiol itself and traditional botanical insecticides.
- Additionally, these compounds demonstrated good effectiveness in greenhouse tests and exhibited moderate toxicity to non-target mammalian cells, indicating potential for safe use in agriculture.*
Article Synopsis
- This study investigates the feasibility of using a low-dose PET/CT scan protocol (1/3 of the standard dose) for cancer patients, focusing on its effectiveness relative to the full-dose regimen.
- Seventy-four cancer patients participated, with assessments showing that image quality and lesion detection rates for the low-dose group were comparable to those found in the full-dose group, particularly when stratified by body mass index (BMI).
- The findings suggest that the BMI-stratified 1/3-dose approach is a viable option, maintaining diagnostic accuracy while potentially enhancing the personalization of clinical imaging protocols.
Article Synopsis
- The study aimed to find a reliable standardized uptake value (SUV) for using in clinical settings by comparing various normalization methods for the SUV of Tc-MDP in normal spine and pelvis bones using SPECT/CT scans. !* -
- Researchers analyzed data from 500 oncology patients, calculating average SUVs based on different body metrics and finding that the SUV method had the least variability, suggesting it might be the most consistent option for clinical use. !* -
- The findings indicate that the SUV from Tc-MDP could be a useful reference for assessing tumor bone metastasis, but results should be evaluated site-specifically, with SUV showing the highest robustness compared to other normalization methods. !*
Article Synopsis
- A universal lesion detection algorithm was developed for both PET/CT and PET/MRI using a dataset from the 2022 AutoPet Challenge, incorporating 2D and 3D models for training and validation.
- The study found that PET/MRI scans had longer delays and lower signal-to-noise ratios compared to PET/CT, yet both showed similar contrast-to-noise ratios and comparable total lesion glycolysis and metabolic tumor volumes.
- Outlier analyses identified anomalies in PET/CT and PET/MRI datasets, highlighting specific areas of false positives and differences in detected lesions between the two imaging methods.
Objective: Positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) are complementary in staging of nasopharyngeal carcinoma (NPC). The combination of MRI and functional imaging from PET in PET/MR is promising in NPC management. Diagnostic performance of PET/CT and PET/MR was compared in 46 patients with histologically confirmed NPC under different disease scenarios, including primary non-metastatic cases, primary metastatic cases, recurrence and/or metastasis after treatment, and post-treatment follow-up cases.
View Article and Find Full Text PDFTotal-body dynamic PET/CT imaging reveals kinetic distribution of [N]NH in normal organs.
Eur J Nucl Med Mol Imaging
November 2024
Purpose: To systematically investigate kinetic metrics and metabolic trapping of [N]NH in organs.
Methods: Eleven participants performed total-body [N]NH dynamic positron emission tomography (PET). Regions of interest were drawn in organs to obtain time-to-activity curves (TACs), which were fitted with an irreversible two-tissue compartment model (2TC) to investigate constant rates K, k and k, and to calculate Ki.
Colony-stimulating factor 1 receptor (CSF1R) is a type III receptor tyrosine kinase that is crucial for immune cell activation, survival, proliferation, and differentiation. Its expression significantly increases in macrophages during inflammation, playing a crucial role in regulating inflammation resolution and termination. Consequently, CSF1R has emerged as a critical target for both therapeutic intervention and imaging of inflammatory diseases.
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- Two series of vanillin derivatives with 1,3,4-oxadiazole and 1,3-thiazolidin-4-one structures were developed and tested for antifungal effects.
- Some compounds demonstrated strong antifungal activity, with one showing over 42 times more effectiveness than vanillin.
- The cytotoxicity tests indicated that these compounds were selective and less harmful to normal mammalian cells, suggesting a promising therapeutic profile.
Article Synopsis
- - Chemokines, particularly the CXCR4 receptor, are crucial in tumor development, and targeting CXCR4 with radioligands like [Ga]Ga-pentixafor holds promising potential for cancer diagnostics and therapy.
- - The study aimed to create improved molecular tracers for CXCR4, synthesizing six new tracers, with [I]I-6 demonstrating the highest targeting efficiency and the best target-nontarget ratio after imaging tests.
- - In trials on tumor-bearing animal models, treatment with [I]I-6 significantly reduced tumor size without notable side effects, highlighting its effectiveness in targeting CXCR4 in cancer therapy.
Objectives: There has been developed a clinical dynamic total-body Ga-DOTATATE PET/CT imaging protocol that allows quantitative imaging of net influx rate (K). Using qualitative and quantitative analyses of clinical studies, this retrospective study aims to assess whether parametric K images improve lesion detectability.
Methods: Using a 194-cm axial field-of-view PET/CT scanner, 52 patients with neuroendocrine tumors underwent a 60-min dynamic total-body Ga-DOTATATE scan.
Importance: Innovative nuclear medicine services offer substantial clinical value to patients. However, these advancements often come with high costs. Traditional payment strategies do not incentivize medical institutes to provide new services nor determine the fair price for payers.
View Article and Find Full Text PDFObjectives: This study aimed to determine the predictive factors of lymph node metastases in clinical T0-T1c stage non-small-cell lung cancers, so as to help making surgical strategy.
Methods: From January 2016 to December 2017, patients with clinical T0-T1c stage non-small-cell lung cancers were retrospectively reviewed. We elucidated the lymph node metastatic incidence and distribution according to the primary tumour radiographic findings and maximal standard uptake values, and extracted the associated clinicopathological factors.
Article Synopsis
- The study examined how men and women with coronary artery disease respond differently to mental stress in terms of their heart health, using advanced imaging techniques.
- Among the participants, women showed higher signs of coronary inflammation, while men had more high-risk heart plaques when experiencing stress-related neural activity.
- Both genders with heightened neural stress activity had an increased risk of major cardiovascular events, indicating that psychological stress impacts heart health in both sexes, but through different mechanisms.
Background: Conventional PET/CT imaging reconstruction is typically performed using voxel size of 3.0-4.0 mm in three axes.
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