Publications by authors named "Hongchao Tian"
Unlabelled: Enterovirus 71 (EV71) is a highly transmissible pathogenic agent that causes severe central nervous system diseases in infected infants and young children. Here, we reported that EV71 VP1 protein could bind to vimentin intermediate filaments expressed on the host cell surface. Soluble vimentin or an antibody against vimentin could inhibit the binding of EV71 to host cells.
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- Enterovirus 71 (EV71) is a significant cause of hand, foot, and mouth disease, primarily affecting infants and young children, leading to severe neurological complications.
- The study found that EV71 infection leads to the rearrangement of vimentin in human astrocytoma cells, creating aggresome-like structures in the cell's perinuclear area that serve as sites for virus replication.
- Vimentin's phosphorylation on serine 82, activated by the EV71 VP1 protein through CaMK-II, is crucial for forming these replication centers, and inhibiting this phosphorylation reduces the virus's ability to replicate.