Publications by authors named "Hongbo Xu"

The CR-39 solid-state nuclear track detector is a commonly used instrument for passively measuring radon. When using CR-39 to measure the radon exhalation rate from the surface of a medium, the effects of leakage are often overlooked. However, to a certain extent, system leakage can affect the accuracy of the measurement results.

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The formation of ice due to global climate change poses challenges across multiple industries. Traditional anti-icing technologies often suffer from low efficiency, high energy consumption, and environmental pollution. Photothermal and hydrophobic surfaces with nano-micro structures (PHS-NMSs) offer innovative solutions to these challenges due to their exceptional optical absorption, heat conversion capabilities, and unique surface water hydrophobic characteristics.

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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic inflammatory responses in the joints, synovial hyperplasia, persistent abnormal proliferation of fibroblast-like synoviocytes (FLSs), and cartilage erosion, leading to joint swelling and destruction. The underlying mechanisms of this disease entail a complex interplay of factors, with long noncoding RNAs (lncRNAs) serving as the main contributors. These lncRNAs, which are over 200 bp in length, are involved in regulating inflammatory responses, joint damage, and FLS growth.

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Chuanxiong Rhizoma is the dried rhizome of the Apiaceae plant Ligusticum chuanxiong Hort (Chuanxiong). Previously, we demonstrated the antihyperuricaemic and anti-acute gouty arthritis effects of Chuanxiong Rhizoma ethyl acetate extracts (ECX B) in mice. However, it is unclear whether ECX B is optimal for lowering urate levels.

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This study combines molecular simulation and experimental methods to investigate the adsorptive separation performance of two metal-organic frameworks (MOFs), ZIF-67 and MIL-53(Al), for Ar/He mixed gases. Experimental and simulation adsorption isotherm data were obtained at temperatures of 298, 200, and 150 K for both Ar and He single-component adsorbates. The ideal adsorbed solution theory (IAST) and grand canonical Monte Carlo (GCMC) simulations calculated the Ar/He selectivity coefficients at different temperatures.

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Sepsis is well known with high mortality, and there is a need for early recognition of septic patients with poor prognosis. The purpose of this study is to evaluate the association between lactate dehydrogenase to albumin ratio (LAR) and the short-term mortality in sepsis. Septic patients were selected from Medical Information Mart for Intensive Care IV database.

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Background: Lipid peroxide accumulation plays significant roles in cerebral ischemia-reperfusion injury (CIRI) through various mechanisms, including ferroptosis. Preserving the neuronal metabolic equilibrium and averting cell death during cerebral ischemia-reperfusion are pivotal for protecting brain function. Yinaoxin granule (YNX) is a widely used Chinese herbal preparations for treating cerebrovascular diseases, but pharmacological mechanism remains ambiguous.

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Background: This study proposes a modified lymph node (LN) staging category (BALN) on the basis of the number of positive LNs before (prepN) and after (ypN) neoadjuvant chemoradiotherapy (nCRT) to improve prognostic stratification in esophageal squamous cell carcinoma (ESCC).

Patients And Methods: A total of 381 patients with ESCC who underwent nCRT at three medical centers were retrospectively enrolled. The ypN categories were scored according to the eighth edition of the American Joint Committee of Cancer (AJCC) staging manual.

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Activating the cGAS-STING pathway presents a promising strategy to enhance the innate immunity and combat the immunosuppressive tumor microenvironment. One key mechanism for triggering this pathway involves the release of damaged DNA fragments caused by nuclear DNA damage. However, conventional cGAS-STING agonists often suffer from limited nucleus-targeting efficiency and potential biotoxicity.

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Designing invisibility devices for required frequency bands is important in anti-detection methods in various fields such as communications, construction, and others. However, traditional design methods are time-consuming, with manual adjustment of parameters and continuous trial and error. Fortunately, the data-driven approach based on deep learning has revolutionized the field.

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Background: Coronary care unit (CCU) patients surviving to discharge still face significant mortality. Delirium is common in CCU patients and has been associated with poorer CCU and in-hospital outcomes.

Aim: To assess the association between delirium and mortality after hospital discharge in CCU survivors.

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The escalating global climate crisis and energy challenges have made the development of efficient radiative cooling materials increasingly urgent. This study presents a machine-learning-based model for predicting the performance of radiative cooling aerogels (RCAs). The model integrated multiple parameters, including the material composition (matrix material type and proportions), modification design (modifier type and content), optical properties (solar reflectance and infrared emissivity), and environmental factors (solar irradiance and ambient temperature) to achieve accurate cooling performance predictions.

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Diabetic foot ulcer (DFU) is a common but devastating complication of diabetes mellitus and might ultimately lead to amputation. Elucidating the regulatory mechanism of wound healing in DFU is quite important for developing DFU management strategies. Here, we show, mecenchymal stem cell (MSC)-derived exosomes promoted the proliferation, migration and angiogenesis of high glucose-treated endothelial cells and reduced cell apoptosis.

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Purpose: A transoral surgical corridor can provide adequate exposure for extirpation of benign tumors arising from the parapharyngeal space (PPS). However, peri-operative complications following a transoral approach to the PPS have not been sufficiently described. This study retrospectively reviewed patients with PPS tumor extirpated via an endoscopic-assisted transoral approach, aiming to evaluate the safety of this approach and summarize the peri-operative complications.

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Article Synopsis
  • This observational study examined the prevalence of diastasis recti abdominis (DRA) in men, identifying risk factors and potential adverse outcomes while exploring diagnostic criteria.
  • A total of 1,575 men participated, and the study revealed a DRA prevalence of 29.78% using an interrectus distance (IRD) > 2 cm, which decreased to 10.16% with an IRD > 3 cm.
  • Key influencing factors included age, BMI, smoking, and exercise, while no strong connections were found between DRA and abdominal muscle function or quality of life, although hernias were significant when using the > 3 cm criterion.
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The reasons for the high recurrence and metastasis after triple-negative breast cancer (TNBC) surgery are the potential presence of micrometastases and disseminated tumor cells in the circulation, as well as the immunosuppressive microenvironment caused by the surgery. To address these issues, this work proposed a platelets (PLTs) based hydrogel delivery system for immuno-chemotherapy, (IL-12+NP-PLT)@dAlg. To utilize the targeting ability of PLTs toward tumor cells and maintain the activity of PLTs, doxorubicin-loaded nanoparticles (NP) were attached on the surface of PTLs (NP-PLT).

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Introduction: Targeted screening of inhibitors of key enzymes in the progression of diabetes from natural products is one of the effective methods for the treatment of diabetes. Polygala has been proved to reduce glucose levels; however, the bioactive compounds in Polygalae Radix (PR) that have anti-diabetic properties are unknown.

Objective: The purpose of this study was to explore the material basis of the anti-diabetic effect of PR by inhibiting α-amylase through an online detection system and molecular docking.

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Macroporous resin is an efficient separation technology that plays a crucial role in the separation and purification of traditional Chinese medicine (TCM). However, the application of macroporous resins in TCM pharmaceuticals is hindered by serious fouling caused by the complex materials used in TCM. This study examines the impact of ultrafiltration (UF) membrane technology on the macroporous resin adsorption behavior of TCM extracts.

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Article Synopsis
  • Photothermal materials typically focus on solar absorption but often overlook thermal radiation losses, which impacts conversion efficiency.
  • This study presents a germanium (Ge) subwavelength structure (SWS) that enhances both solar absorption (98.8% peak) and minimizes infrared emissivity (0.32).
  • The structure achieved a significant temperature rise of 50 °C with 800 W/m heating power under 1000 W/m solar illumination and exhibits impressive stability and hydrophobic properties, making it ideal for use in solar panels and optoelectronic devices.
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Article Synopsis
  • The study analyzed the prevalence of diastasis recti abdominis (DRA) among 1,000 postpartum women over 30 years, finding significant occurrence especially with an inter-recti distance (IRD) greater than 2 cm (36% at 3 years postpartum).
  • Key risk factors identified for DRA included higher body mass index (BMI), greater number of pregnancies, having twins, and diabetes, affecting different time points postpartum (e.g., BMI was significant at 10 years).
  • The results suggest a need to refine diagnostic criteria for DRA to minimize unnecessary diagnoses and improve early intervention strategies for affected women.
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Article Synopsis
  • Researchers are developing a new method for creating artificial heterojunctions from 2D materials to improve device applications by focusing on strong covalent bonds instead of weak van der Waals forces.
  • This new approach enhances charge-transfer dynamics and allows for customizable band structure regulation at the molecular level, making it more efficient and cost-effective.
  • Experimental and theoretical analyses reveal that the efficiency of this method relies on organic electronegativity, leading to great performance in various applications, thereby offering a promising platform for future advanced devices.*
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Introduction And Hypothesis: The objective was to investigate whether diastasis recti abdominis (DRA) can cause adverse outcomes for different long-term postpartum women.

Methods: We recruited 437 long-term postpartum women at five different time points (3, 5, 10, 20, and 30 years postpartum respectively). Inter-recti distance (IRD) and linea alba or umbilical hernia were measured by ultrasound.

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The potential applications of stretchable strain sensors in wearable electronics have garnered significant attention. However, developing susceptible stretchable strain sensors for practical applications still poses a considerable challenge. The present study introduces a stretchable strain sensor that utilizes silver nanowires (AgNWs) embedded into a polydimethylsiloxane (PDMS) substrate.

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A high performance liquid chromatography-ultraviolet-visible detector-electrospray ionization-ion trap-time-of-flight-mass spectrometry-total antioxidant capacity determination (HPLC-UVD-ESI-IT-TOF-MS-TACD) new online technique was developed for efficient screening of potential antioxidant active components in Prunus persica flowers (PPF) from 4 origins. Through this online system, 46 compounds were initially identified, while 20 compounds with DPPH binding activity and 21 compounds with FRAP binding activity were detected. The antioxidant activities of 9 compounds obtained from the screening were then validated in DNA oxidative damage protection study.

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