MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1α/VEGF Signaling Pathway by Targeting CAB39.

MicroRNAs (miRNAs) are widely expressed and regulate most biological functions. According to several research groups, miR-451 expression is decreased in glioma cells. A previous study also confirmed that miRNA-451 inhibits the PI3K/AKT signaling pathway by directly targeting CAB39, which inhibits glioma cell growth and proliferation and induces apoptosis.

miRNA-451 inhibits glioma cell proliferation and invasion by downregulating glucose transporter 1.

MicroRNAs play an important role in tumor development and progression. Tumor growth is closely associated with glucose metabolism. Specifically, tumor cells produce energy (ATP) under aerobic and anaerobic conditions through glycolysis and metabolites, such as lactic acid and ATP, as a result of the Warburg effect.

Complex responses of spring vegetation growth to climate in a moisture-limited alpine meadow.

Since 2000, the phenology has advanced in some years and at some locations on the Qinghai-Tibetan Plateau, whereas it has been delayed in others. To understand the variations in spring vegetation growth in response to climate, we conducted both regional and experimental studies on the central Qinghai-Tibetan Plateau. We used the normalized difference vegetation index to identify correlations between climate and phenological greening, and found that greening correlated negatively with winter-spring time precipitation, but not with temperature.