MRI-based clinical-radiomics nomogram model for predicting microvascular invasion in hepatocellular carcinoma.

Background: Preoperative microvascular invasion (MVI) of liver cancer is an effective method to reduce the recurrence rate of liver cancer. Hepatectomy with extended resection and additional adjuvant or targeted therapy can significantly improve the survival rate of MVI+ patients by eradicating micrometastasis. Preoperative prediction of MVI status is of great clinical significance for surgical decision-making and the selection of other adjuvant therapy strategies to improve the prognosis of patients.

Bone marrow-derived mesenchymal stem cells expressing BMP2 suppress glioma stem cell growth and stemness through Bcl-2/Bax signaling.

Objectives: To find an effective molecule that controls glioma stem cell (GSC) proliferation and differentiation for the development of future therapeutic interventions against glioblastoma.

Material And Methods: Bone marrow-derived mesenchymal stem cells (BMSCs) were infected with a lentiviral vector to express BMP2. Cell viability, cell counting, and tumor sphere formation assays, as well as flow cytometry, immunofluorescence staining, and Western blotting were used to investigate the effects of BMSC-BMP2 on GSCs.

Neuroprotective effect of rhaponticin against Parkinson disease: Insights from in vitro BV-2 model and in vivo MPTP-induced mice model.

Parkinson's disease (PD) is a complex neurodegenerative illness associated with the loss or damage to neurons of the dopaminergic system in the brain. Few therapeutic approaches and considerable side effects of conventional drugs necessitate a new therapeutic agent to treat patients with PD. Rhaponticin is a natural hydroxystilbene, found in herbal plants such as Rheum rhaponticum, and known to have desirable biological activity including anti-inflammatory properties.

Multiflorane suppresses the proliferation, migration and invasion of human glioblastoma by targeting MAPK signalling pathway.

Purpose: Glioblastoma is one common malignant tumors of central nervous system and its treatment is limited by the unavailability of chemotherapeutic agents. This study was therefore undertaken to evaluate the anticancer effects of Multiflorane molecule against the U87 human glioblastoma cells and normal human astrocytes.

Methods: The CCK8 assay was used to determine cell proliferation.

Clinical efficacy of MVD combined with PSR in the treatment of primary trigeminal neuralgia.

Clinical efficacy of microvascular decompression (MVD) combined with percutaneous stereotactic radiofrequency rhizotomy (PSR) in the treatment of primary trigeminal neuralgia was investigated. The medical records of 141 patients with primary trigeminal neuralgia admitted to Shandong Provincial Hospital from May 2011 to June 2013 were collected. Among them, 63 patients received MVD surgery and were set as group A, while the other 78 received MVD combined with PSR and were as group B.

Effect of subdural muscle packing in repairing dura mater after retrosigmoid craniotomy.

Objective: This study was performed to evaluate a new type of autologous muscle tamponade to repair dura mater that has undergone dural defects to prevent cerebrospinal fluid leakage or subcutaneous fluid accumulation.

Methods: Three hundred thirty-two patients who underwent retrosigmoid craniotomy were selected and divided into two groups: bone window craniotomy and bone flap craniotomy. Each group was further divided into two groups: artificial dura repair and autologous muscle repair.

MiRNA-323-5p Promotes U373 Cell Apoptosis by Reducing IGF-1R.

BACKGROUND MicroRNA regulates mammalian cell growth in terms of its proliferation and apoptosis by controlling the expression of target genes. MiRNA-323-5p plays an important role in regulating cell growth and death within various types of cells. The function of miRNA-323-5p and its possible molecular mechanism in human cerebral glioma U373 cells remains to be further confirmed.

The complete mitochondrial genome sequence of a rat 9L glial neoplasms CNS-1 cell line.

We sequenced a complete mitochondrial genome sequence of a rat 9L glial neoplasms disease CNS-1 cell line for the first time (Accession No. KM657952). The total length of the mitogenome was 16,306 bp and coding 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes.

Therapeutic time window and effect of intracarotid neural stem cells transplantation for intracerebral hemorrhage.

This study investigated the therapeutic effect of neural stem cells transplanted via the carotid artery at different times after intracerebral hemorrhage. A great number of 5-bromo-2-deoxyuridine-positive cells were observed surviving and distributed evenly in the perihematoma areas. Phenotypes of grafted cells depended upon time of transplantation, and the later the cells were transplanted, the larger the percentage of cells that differentiated into neurons.