Development and validation of machine learning-based prediction model for outcome of cardiac arrest in intensive care units.

Cardiac arrest (CA) poses a significant global health challenge and often results in poor prognosis. We developed an interpretable and applicable machine learning (ML) model for predicting in-hospital mortality of CA patients who survived more than 72 h. A total of 721 patients were extracted from the Medical Information Mart for Intensive Care IV database, divided into the training set (n = 576) and the internal validation set (n = 145).

The relationship between negative emotions and adjustment disorder in young adults: the mediating role of rumination and insomnia.

Introduction: This study aimed to investigate the influence of negative emotions on adjustment disorder (AjD) in young adults, focusing on the mediating role of rumination and insomnia.

Methods: The study recruited 2015 young patients (aged 18-35) receiving treatment at the Psychosomatic Medicine Department of the Affiliated Encephalopathy Hospital of Zhengzhou University from February 2023 to March 2024. Participants completed the Depression Anxiety and Stress Scale (DASS), Ruminative Responses Scale (RRS), Insomnia Severity Scale (ISI), and Adjustment Disorder - New Module 20(ADNM-20) to assess negative emotions, rumination thinking, sleep status, and AjD.

Pixel level deep reinforcement learning for accurate and robust medical image segmentation.

Existing deep learning methods have achieved significant success in medical image segmentation. However, this success largely relies on stacking advanced modules and architectures, which has created a path dependency. This path dependency is unsustainable, as it leads to increasingly larger model parameters and higher deployment costs.

Effect of different natural antioxidants on the quality promotion of pork chip snacks during storage as revealed by lipid profiles and volatile flavor compounds.

This study primarily investigated the effects of different natural antioxidants (ascorbic acid, rosemary extract, PostbioYDFF-3®, and NatuProtec®) on changes in the lipid profiles and volatile flavors of pork chip snacks (PCS) during storage via lipidomic techniques and SPME-GC-MS. Compared with the control, the PCS containing different natural antioxidants exhibited obvious reductions in TBARS, peroxide, and acid values after 90-day storage (P < 0.05).

From reticulated platelets to immature platelet fraction: structure, function, and clinical applications.

In comparison to mature platelets, reticulated platelets (RPs) are newly released from the bone marrow and exhibit a larger size, higher reactivity, and a greater quantity of RNA, and can be an agile indicator of platelet turnover. The transcriptome associated with platelet function is significantly upregulated in RPs, which is a possible explanation for RPs intrinsic hyper-reactivity. We presented a comprehensive overview of the detection techniques for RPs.

Fully Integrated Centrifugal Microfluidics for Rapid Exosome Isolation, Glycan Analysis, and Point-of-Care Diagnosis.

Exosomes present in the circulatory system demonstrate considerable promise for the diagnosis and treatment of diseases. Nevertheless, the complex nature of blood samples and the prevalence of highly abundant proteins pose a significant obstacle to prompt and effective isolation and functional evaluation of exosomes from blood. Here, we present a fully integrated lab-on-a-disc equipped with two nanofilters, also termed iExoDisc, which facilitates automated isolation of exosomes from 400 μL blood samples within 45 min.

A Multivariate prediction model for amlodipine therapeutic efficacy in pediatric primary hypertension.

Background: There are currently no biomarker-based prediction models for amlodipine therapeutic efficacy in pediatric hypertension. This study aimed to identify potential biomarkers and establish a biomarker-based model for predicting amlodipine therapeutic efficacy in pediatric primary hypertension (PH).

Methods: From January 2022 to December 2023, 165 children and adolescents with PH prescribed amlodipine were recruited at our department for a prospective observational study.

Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines.

Human Th17/type 17 cells express the chemokine receptor CCR6, but the functions of CCR6 and other chemokine receptors in human type 17 Th cell extravasation have not been fully delineated. Here we show that human peripheral blood CD4CCR6 T cells co-expressing CCR2 have a pathogenic Th17 signature, can produce inflammatory cytokines without T cell receptor activation, and show enhanced expression of pathogenicity-associated and activation-associated genes in the cerebrospinal fluid of patients with multiple sclerosis as compared to controls. In flow chambers with activated endothelial cell (EC) monolayers, CD4CCR6CCR2 T cells are efficient at transendothelial migration (TEM).

Optimizing cancer therapy through metal organic frameworks-based nanozymes.

Cancer remains a leading global health challenge, with conventional treatments facing limitations due to drug resistance and adverse effects arising from tumor heterogeneity. Nanozymes, nanomaterials mimicking natural enzymes, have emerged as promising therapeutic agents owing to their catalytic efficiency, stability, and biocompatibility. Among nanozymes, MOFs-based nanozymes are particularly attractive due to the inherent tunability of MOFs, which allows for precise control over their structure, porosity, and catalytic activity.

GWAS-based population genetic analysis identifies bZIP29 as a heterotic gene in maize.

Understanding the role of heterotic genes in contributing to heterosis is essential for advancing hybrid breeding. We analyzed plant height (PH), ear height (EH), and transcriptomic data from a maize hybrid population. GWAS identified that dominance effects of QTL play a significant role in hybrid traits and mid-parent heterosis.

Amlexanox ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting Th17 cells and the NF-κB signal pathway.

Psoriasis is a chronic inflammatory dermatological disorder characterized by the aberrant differentiation and hyperproliferation of epidermal keratinocytes, boosted immune cell infiltration, and cytokine and chemokine production. Patients with psoriasis experience persistent discomfort and their conditions remain incurable. Therefore, development of safe and effective treatments for psoriasis is critical.

Ratiometric fluorescence nanoprobe based on nitrogen-doped carbon dots for Cu and Fe detection.

Heavy metal ions pollution in environmental waters has an increasing impact on human health. As two common metal ions, copper ions (Cu) and ferric ions (Fe) widely exist in nature and play a vital role in life process. Therefore, it is significant to design sensitive and simple detection approaches for Cu and Fe.

1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells.

Hepatic fibrosis (HF) is a pathological process in many liver diseases, which lack of specific agents. Pirfenidone (PFD) derivatives are potential new drug. The purpose of this study was to investigate the effect and immunological mechanism of PFD derivatives on HF.

Incorporation of transglutaminase potentially promoted the gelling properties and sensorial attributes of lysine-rich salt-reduced frankfurters.

This study was designed to investigate the promotive effect of transglutaminase (TG) on the gelling properties and sensorial attributes of lysine (Lys)-rich salt-reduced frankfurters. The results revealed that the addition of 0.3% TG yielded acceptable cooking loss and emulsion stability in Lys-rich salt-reduced frankfurters, significantly improved their textural parameters, and visibly optimised their microstructure.

[Analysis of Clinical Epidemiological Characteristics of 15,967 Lung Cancer Surgery Patients in Yunnan Cancer Hospital from 2013 to 2022].

Background: Lung cancer is a disease with a high incidence rate in Yunnan province, yet there is a paucity of large-scale studies on its clinical epidemiology. This research aims to investigate the epidemiological characteristics of patients who underwent lung cancer surgery at Yunnan Cancer Hospital over the past decade, thereby providing a theoretical basis for the prevention and treatment of lung cancer.

Methods: Clinical data were collected from 15,967 patients who underwent lung cancer surgery at Yunnan Cancer Hospital between 2013 and 2022.

Rice bran protein O/W emulsion enhanced by microfluidization and gum arabic: Physicochemical property, environmental stability, oxidation kinetic.

In order to solve the problem of wastage of rice bran resources and make full use of the rice bran protein (RBP) with high nutrition, an oil-in-water (O/W) emulsion was successfully prepared from RBP by dynamic high pressure microjet technology (DHPM) assisted with gum arabic (GA), which provided an effective method for fully exploiting RBP resources. The results indicated that, the emulsion treated under 120 MPa exhibited superior properties. The dispersion of the emulsion droplets was more uniform, the zeta potential was -24.

Nonadditive regulation confers phenotypic variation in hybrid maize.

Our knowledge of how the parental genomes interact to shape hybrid performance remains limited. This work established four hybrid maize populations and evaluated plant height (PH) in both the parental and hybrid populations, generating an extensive transcriptome and translatome dataset. We conducted a genome-wide association study, expression quantitative trait locus (eQTLs) mapping, transcriptome-wide association mapping (TWAS), and allele-specific expression analysis to elucidate the regulatory mechanisms underlying PH variation in hybrids.

Differential resistance to nematode infection is associated with the genotype- and age-dependent pace of intestinal T cell homing.

The resistance of inbred mice to nematode infections varies depending on the extent of protective Th2 responses. Here, we compared two mouse lines differing in resistance to infection with the enteric nematode Heligmosomoides polygyrus bakeri despite the similar instruction of GATA-3+ T effector cells. Resistant BALB/c mice rapidly recruited high numbers of Th2 cells to the gut within the 1-week time frame required for larval development in the intestinal submucosa.

The application of magnifying endoscopy in the diagnosis of cervical lesions.

Objective: This study aimed to assess the sensitivity and specificity of magnifying endoscopy in the examination of patients with high-risk factors for cervical lesions.

Methods: Two equally skilled colposcopy specialists examined 59 patients admitted to the Obstetrics and Gynecology Hospital of Fudan University between March 14, 2023, and April 15, 2023. These patients underwent both colposcopy and magnifying endoscopy examinations.

A green cycle strategy for selective leach and recovery of critical metals from spent lithium-ion batteries: Experimental and new mechanistic insights.

With the global surge in lithium-ion batteries (LIBs), recycling spent LIBs has become an essential and urgent research area. In the context of global efforts to promote sustainable development, and achieve energy conservation and emission reduction, advancing recycling technologies that efficiently recover critical metals like Ni, Co, Mn, and Li is crucial. Herein, a novel and environmentally friendly simplified process for selectively extracting critical metals from the mixed electrode materials of spent LIBs is proposed for the first time.

Lidocaine Inhibits the Proliferation of Non-Small Cell Lung Cancer and Exerts Anti-Inflammatory Effects Through the TLR-9/MyD88/NF-κB Pathway.

Lung cancer represents a significant global health burden, with non-small cell lung cancer (NSCLC) being the most common subtype. The current standard of care for NSCLC has limited efficacy, highlighting the necessity for innovative treatment options. Lidocaine, traditionally recognized as a local anesthetic, has emerged as a compound with potential antitumor and anti-inflammatory capabilities.

The link between the atherogenic index of plasma and the risk of hypertension: Analysis from NHANES 2017-2020.

Background: The atherogenic index of plasma (AIP) is a newly identified metabolic marker for atherosclerosis. However, there are inconsistent conclusions regarding the relationship between AIP and hypertension.

Methods: The study subjects were sourced from the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020.

Interfacial seed-assisted FAPbI crystallization and phase stabilization enhance the performance of all-air-processed perovskite solar cells.

Formamidinium lead triiodide (FAPbI) has received significant attention in the field of perovskite solar cells (PSCs) owing to its excellent optoelectronic properties and high thermal stability. However, the photoactive α-FAPbI perovskites are highly susceptible to degradation into non-perovskite δ-FAPbI phases, especially under humid conditions, which severely diminishes the device performance of FAPbI PSCs. Here, we propose an interfacial seeding strategy for regulating crystallization and stabilizing α-FAPbI perovskites in humid air.

ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Challenged .

, a recognized probiotic, improves intestinal health in animals, but the mechanism remains unclear. This study investigates the mechanisms by which ZY15, isolated from healthy pig feces, mitigates intestinal barrier damage and inflammation caused by oxidative stress in Enterotoxigenic (ETEC) K88-challenged mice. The results indicated that ZY15 increased antioxidant capacity by reducing serum reactive oxygen species (ROS) and superoxide dismutase (SOD) levels.

Altered asymmetry of amygdala volume mediates food addiction and weight gain.

Background: Food addiction and an impulsive personality can increase overeating, which can lead to weight gain. The amygdala and nucleus accumbens (NAcc) are critical for regulating obesogenic behaviour. However, whether the amygdala or the NAcc acts as the neural basis for the regulation of food addiction, impulsive personality, and body weight remains unclear.