ASAF: altered spontaneous activity fingerprinting in Alzheimer's disease based on multisite fMRI.

Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD).

Strategy for Extending the Nitrogen Chain: The Bis(1,2,3-triazole) Formation Reaction from Tosylhydrazones and -Amino Azole.

A facile and versatile synthesis strategy for the bis(1,2,3-triazole) formation reaction was developed from tosylhydrazones and -amino (-NH) azole instead of -amino amine derivatives. The novel energetic compounds containing the bicycle catenated six-nitrogen chain (N) and the first example of N neutral compounds were synthesized in a moderate or high yield. The possible mechanism of bis(1,2,3-triazole) formation reaction based on amino azole of -NH was verified by the X-ray crystal structure of key intermediates.

Mechanism of ozonation enhanced formation of haloacetaldehydes during subsequent chlorination.

Haloacetaldehydes (HAs) are the third prevalent group of disinfection by-products of great health concern. A bench-scale study was performed to investigate the formation and speciation of HAs in raw and treated waters after chlorination and ozonation-chlorination. Pre-ozonation resulted in enhanced HA formation during subsequent chlorination, and the HA yields from ozonation-chlorination were 1.

Polynitro-Functionalized Triazolylfurazanate Triaminoguanidine: Novel Green Primary Explosive with Insensitive Nature.

Exploring a green and safe primary explosive to replace very toxic and sensitive lead azide and lead styphnate takes great efforts. Here, a series of polynitro-functionalized triazolylfurazanate energetic materials have been reported. These new compounds were fully characterized by infrared, multinuclear NMR spectra, mass spectra, elemental analysis, and differential scanning calorimetry measurements.

Fluorescent sensor array for separation-free dopamine analogue discrimination via polyethyleneimine-mediated self-polymerization reaction.

The effective discrimination of dopamine (DA) analogues is an enduring challenge because of their very tiny structural differences, and thus a separation technique is generally required during the conventional analysis. In this study, a hyperbranched polyethyleneimine (hPEI)-based fluorescent sensor array has been constructed for the separation-free and effective differentiation of four DA analogues. The discrimination includes two steps: firstly, the formation of fluorescent polymer nanoparticles (FPNs) with diverse emission profiles via hPEI-mediated self-polymerization reaction of DA analogues and secondly, the linear discriminant analysis of fluorescence patterns of the formed FPNs for the differentiation of DA analogues.

A novel synthesis of silver nanowires by using 6-chlorohexylzinc bromide as an additive for low haze transparent conductive films.

High-quality silver nanowires (AgNWs) with a small diameter of ∼20 nm and a length of ∼40 μm were prepared by using a novel organic 6-chlorohexylzinc bromide as an assistant additive. The diameter of as-synthesized AgNWs was confirmed to be strongly dependent on the dosage of 6-chlorohexylzinc bromide. Moreover, a two-dimensional (2D) transparent conductive film (TCF) with an excellent optical performance was fabricated by as-synthesized AgNWs, which has a 90.

Risk Factor for Residue After Uterine Artery Chemotherapy and Embolization in Combination with Dilatation and Curettage for Treating Caesarean Scar Pregnancy.

Objective: We aimed to investigate the potential risk factors for residual lesions after uterine artery chemotherapy and embolization (UACE) in combination with dilatation and curettage (D&C) in patients with cesarean scar pregnancy (CSP).

Settings: Retrospective case-control study.

Method: Univariate analysis and logistic analysis were applied to analyze these data to assess the risk factor of residue after UACE in combination with D&C.

Oxidation of isoprothiolane by ozone and chlorine: Reaction kinetics and mechanism.

Isoprothiolane (IPT) was one of the most commonly used pesticides around the world. It was reported to be the highest concentration and frequency of detection of 13 most commonly used pesticides in Mekong Delta recently. The oxidation degradation kinetic of ozone and chlorine with IPT and the identification of the degradation products was investigated in this research.

The beneficial effect of cathodic hydrogen peroxide generation on mitigating chlorinated by-product formation during water treatment by an electro-peroxone process.

The formation of chlorinated by-products is a major concern associated with electrochemical water treatment processes. This study investigated the formation of chlorinated by-products during surface water treatment by a newly developed electrochemical advanced oxidation process (EAOP), the electro-peroxone (E-peroxone) process, which couples ozonation with in situ electro-generation of hydrogen peroxide (HO) from cathodic oxygen reduction. Due to the enhanced ozone (O) conversion to hydroxyl radicals (•OH) by electro-generated HO, the E-peroxone process considerably accelerated the abatement of ozone-refractory micropollutants such as clofibric acid and chloramphenicol in the selected surface water compared to conventional ozonation.

Diffusion-weighted imaging as a part of PET/MR for small lesion detection in patients with primary abdominal and pelvic cancer, with or without TOF reconstruction technique.

Objectives: To investigate the value of diffusion-weighted imaging (DWI) in detection of small lesions (≤ 10 mm) in patients with primary abdominal and pelvic cancer in hybrid PET/MR with or without time-of-flight (TOF) technique.

Materials And Methods: Twenty patients (11 females and 9 males, mean age 67.23 ± 12.

Revisiting the reactive chemistry of FOX-7: cyclization of FOX-7 affords the fused-ring polynitro compounds.

A novel fused-ring polynitro compound (5) and a cyclic compound featuring gem-dinitromethylene and nitroso groups (7) were synthesized from 1,1-diamino-2,2-dinitroethylene (FOX-7). Both compounds exhibit high density, decent thermal stability, high detonation performances, and low mechanical sensitivities. This newly developed derivatization strategy enriches the ever-expanding reactive chemistry of FOX-7.

CADM2 inhibits human glioma proliferation, migration and invasion.

Malignant glioma is one of the most common malignant tumors in the brain parenchyma with a poor prognosis. Cell adhesion molecules (CADMs) immunoglobulin super family is involved in the maintenance of cell adhesion, polarity and tumor suppression. However, the role and mechanisms of CADM2 in human glioma have yet to be elucidated.

Serum 14-3-3η Could Improve the Diagnostic Rate of Rheumatoid Arthritis and Correlates to Disease Activity.

Objectives: Serum 14-3-3η is a novel joint-derived proinflammatory mediator associated with rheumatoid arthritis (RA). This study aimed to evaluate the diagnostic capacity of serum 14-3-3η and its correlation with clinical variables in patients with RA.

Methods: A total of 94 patients with RA and 80 age- and sex-matched controls, including 40 healthy subjects, were included.

One-Step Synthesis of Silver Nanowires with Ultra-Long Length and Thin Diameter to Make Flexible Transparent Conductive Films.

High aspect ratio silver nanowires (AgNWs) with ultra-long length and thin diameter were synthesized through bromine ion (Br)-assisted one-step synthesis method. The bromine ions were used as pivotal passivating agent. When the molar ratio of Br/Cl was 1:4, the average diameter of AgNWs was as low as ~40 nm, the average length was as high as ~120 μm, and the aspect ratio reached 2500.

Coffee consumption and risk of pancreatic cancer: a systematic review and dose-response meta-analysis.

The association between coffee consumption and pancreatic cancer risk has been extensively studied; however, there is no consistent conclusion. Therefore, this meta-analysis study sought to evaluate dose-response relationship between them. A search was conducted using the PubMed and Web of Science databases.

Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.

Sulforaphane (SFN) is abundant in cruciferous plants, providing significant protection against many chronic diseases. With the aim of clarifying the efficacy of sulforaphane in diabetic retinopathy (DR), a series of systematic studies were carried out in the present study. Male Sprague Dawley rats were intraperitoneally injected with streptozotocin (STZ, 65 mg/kg), and those with confirmed diabetes mellitus were given different doses of SFN (0.

People-centred integrated care in urban China.

In most countries, the demand for integrated care for people with chronic diseases is increasing as the population ages. This demand requires a fundamental shift of health-care systems towards more integrated service delivery models. To achieve this shift in China, the World Health Organization, the World Bank and the Chinese government proposed a tiered health-care delivery system in accordance with a people-centred integrated care model.

Preoperative proteinuria and clinical outcomes in type B aortic dissection after thoracic endovascular aortic repair.

Background Proteinuria is a marker of poor outcomes in several diseases; however, few studies have been conducted to explore the prognostic value of proteinuria, assessed by urine dipstick test, for clinical outcomes in patients with type B acute aortic dissection (TBAD) undergoing thoracic endovascular aortic repair (TEVAR). Methods Consecutive patients with TBAD undergoing TEVAR were enrolled from January 2010 to July 2015. Proteinuria was defined as trace or higher, according to the results of urine dipstick testing.

TGF-beta/TGF-beta RII/CLC-3 axis promotes cognitive disorders in diabetes.

Transforming growth factor beta (TGF-beta) and Chloride channel-3 (CLC-3) are critical for inflammatory response, cellular proliferation and apoptosis in hippocampus neurons. However, the relationship between CLC-3 and TGF-beta/TGF-beta Receptor II (RII) pathway in diabetic encephalopathy (DE) is unknown. In this study, both diabetes rat model and diabetes cell model were employed to elucidate the mechanisms involved.

Gene expression profile analysis of U251 glioma cells with shRNA-mediated SOX9 knockdown.

Purpose: In glioma, the sex-determining region Y-box 9 gene (SOX9) is overexpressed and its downregulation leads to inhibition of cell proliferation, invasion and increased cell apoptosis. To further evaluate the molecular and signal pathways associated with the function of SOX9 and SOX9 target genes, a global gene expression profile of the established SOX9-knockdown U251 cells was investigated.

Methods: The molecular function and biological pathways of differentially expressed genes (DEGs) were identified by gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.

Decreased GlycA after lifestyle intervention among obese, prediabetic adolescent Latinos.

Background: Obese youth with prediabetes are at increased risk for premature morbidity and mortality through multiple mechanisms, including increased systemic inflammation. GlycA is a novel measure of systemic inflammation that predicts type II diabetes, cardiovascular events, and all-cause mortality in adults.

Objective: The purpose of the present study was to examine changes in GlycA after lifestyle intervention among obese, prediabetic Latino youth.

Comparison of chlorination behaviors between norfloxacin and ofloxacin: Reaction kinetics, oxidation products and reaction pathways.

Fluoroquinolones (FQs) are very ubiquitous in water environment in China. The commonly application of free available chlorine (FAC) during water treatment stimulated the focus on the transformation of FQs during chlorination. Among these FQs, norfloxacin (NOR) and ofloxacin (OFL) are the representatives of secondary amine FQs and tertiary amine FQs, respectively.

The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health.

Melatonin is a neurohormone associated with sleep and wakefulness and is mainly produced by the pineal gland. Numerous physiological functions of melatonin have been demonstrated including anti-inflammation, suppressing neoplastic growth, circadian and endocrine rhythm regulation, and its potent antioxidant activity as well as its role in regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others. In this review, we summarize the recent advances related to the multiple protective roles of melatonin receptor agonists, melatonin and N-acetylserotonin (NAS), in brain injury, liver damage, and bone health.

Fluorescent Gold Nanocluster-Based Sensor Array for Nitrophenol Isomer Discrimination via an Integration of Host-Guest Interaction and Inner Filter Effect.

The rapid discrimination of nitrophenol isomers has been a long-standing challenge because of the tiny structural differences among the isomers. In this study, a fluorescent sensor array based on three different-color emitting gold nanoclusters (Au NCs) that were functionalized with three different ligands and a cocapping ligand β-cyclodextrin (β-CD) has been constructed for the facile discrimination of three nitrophenol isomers via the linear discriminant analysis of isomer-induced fluorescence quenching patterns. The fluorescence quenching occurs in two steps: first, β-CDs adsorb nitrophenol isomers onto the surface of Au NCs via a host-guest interaction; second, each nitrophenol isomer quenches the fluorescence of a specific type of Au NCs through diverse inner filter effect.

Multiplexed microRNA Expression Profiling by Combined Asymmetric PCR and Label-Free Detection using Silicon Photonic Sensor Arrays.

Analysis methods based upon the quantitative, real-time polymerase chain reaction are extremely powerful; however, they face intrinsic limitations in terms of target multiplexing. In contrast, silicon photonic microring resonators represent a modularly multiplexable sensor array technology that is well-suited to the analysis of targeted biomarker panels. In this manuscript we employ an asymmetric polymerase chain reaction approach to selectively amplify copies of cDNAs generated from targeted miRNAs before multiplexed, label-free quantitation through hybridization to microring resonator arrays pre-functionalized with capture sequences.