An innovative and safe method to manage the inter-segmental plane using the "Inserted Multilateral Cutting Method" in pulmonary segmentectomy.

Background: Management of the intersegmental plane (ISP) remains a challenge in lung segmentectomy to minimize intra- or postoperative complications and damage to the lungs. The purpose of this study was to assess the novel method's clinical feasibility and safety for segmentectomy.

Methods: A total of 205 patients who underwent video-assisted thoracoscopic surgery (VATS) segmentectomy from May 2018 to January 2020 were retrospectively reviewed.

Seamless observations of chlorophyll-a from OLCI and VIIRS measurements in inland lakes.

The Visible Infrared Imaging Radiometer Suite (VIIRS) and Ocean and Land Colour Instrument (OLCI) are two main instruments for the ocean color community to observe the global lake environment in the following decades. Despite their applications to retrieve various water optical parameters, the spatial and temporal resolutions of individual sensors cannot meet the requirements for lake monitoring effectively. To date, the possibility of complementary observations through the OLCI-VIIRS data to lake aquatic environments remains unclear.

Eutrophication exacerbated organic pollution in lakes across China during the 1980s-2010s.

Lakes are vital sources of drinking water and essential habitats for humans and various other living organisms. However, many lakes face organic pollution due to anthropogenic disturbance and climatic influence, and the spatiotemporal changes of organic pollution in lakes over a large area are still unclear. Based on three monitoring datasets of chemical oxygen demand (COD) in 390 lakes, this study demonstrated the apparent spatiotemporal differences of organic pollution in lakes during the 1980s-2010s and the effects of water eutrophication and salinization.

Perioperative sintilimab and neoadjuvant anlotinib plus chemotherapy for resectable non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 2 trial (TD-NeoFOUR trial).

This open-label, single-arm, phase 2 trial evaluated the efficacy and safety of neoadjuvant sintilimab combined with anlotinib and chemotherapy, followed by adjuvant sintilimab, for resectable NSCLC. Forty-five patients received anlotinib (10 mg, QD, PO, days 1-14), sintilimab (200 mg, day 1), and platinum-based chemotherapy of each three-week cycle for 3 cycles, followed by surgery within 4-6 weeks. Adjuvant sintilimab (200 mg) was administered every 3 weeks.

Satellite algorithms for retrieving dissolved organic carbon concentrations in Chinese lakes.

Water quality and the carbon cycle in lakes are strongly related to the concentration of dissolved organic carbon (DOC). Several regional algorithms have been proposed to remotely retrieve lake DOC concentration at a regional scale, but further efforts are needed to reliably retrieve DOC concentration over a large area. Based on bio-optical measurements from 55 lakes across China, this study investigates feasible satellite algorithms for retrieving DOC concentrations from OLCI/Sentinel-3 imagery.

Substantial increase of organic carbon storage in Chinese lakes.

Previous studies typically assumed a constant total organic carbon (OC) storage in the lake water column, neglecting its significant variability within a changing world. Based on extensive field data and satellite monitoring techniques, we demonstrate considerable spatiotemporal variability in OC concentration and storage for 24,366 Chinese lakes during 1984-2023. Here we show that dissolved OC concentration is high in northwest saline lakes and particulate OC concentration is high in southeast eutrophic lakes.

Optical coherence tomography angiography for microaneurysms in anti-vascular endothelial growth factor treated diabetic macular edema.

Background: We aimed to evaluate microaneurysms (MAs) after treatment with anti-vascular endothelial growth factor (anti-VEGF) therapy to understand causes of chronic edema and anti-VEGF resistance.

Methods: Patients with non-proliferative diabetic retinopathy, with or without macular edema were recruited. Optical coherence tomography angiography (OCTA) MAs-related parameters were observed, including the maximum diameter of overall dimensions, material presence, and flow signal within the lumen.

Outdoor tubular photobioreactor microalgae-microorganisms biofilm treatment of municipal wastewater: Enhanced heterotrophic assimilation and synergistic aerobic denitrogenation.

This research evaluated a microalgae consortium (MC) in a pilot-scale tubular photobioreactor for municipal wastewater (MWW) treatment, compared with an aeration column photobioreactor. Transitioning from suspended MC to a microalgae-microbial biofilm (MMBF) maintained treatment performance despite increasing influent from 50 L to 150 L in a 260 L system. Carbon and nitrogen removal were effective, but phosphorus removal varied due to biofilm shading and the absence of phosphorus-accumulating organisms.

Spatiotemporal heterogeneity of lake carbon dioxide flux leads to substantial uncertainties in regional upscaling estimates.

Limited field samplings result in significant uncertainties in regional and global estimates of lake carbon dioxide (CO) emissions. However, quantitative analysis of uncertainty in regional lake CO emission estimates remains unclear. In this study, we utilized satellite data to estimate carbon dioxide flux from 113 eastern China lakes, revealing substantial spatial and temporal variations in flux, averaging 18.

Influence of climate extremes on long-term changes in cyanobacterial blooms in a eutrophic and shallow lake.

Climate change and human activities have crucial effects on the variations in phytoplankton blooms in lakes worldwide. A record-breaking heatwave and drought event was reported in the middle and lower reaches of the Yangtze River during the summer of 2022, but only little is known about how cyanobacterial blooms in lakes respond to such climate extremes. Here, we utilized MODIS images to generate the area, occurrence, and initial blooming date (IBD) of cyanobacterial blooms in Lake Chaohu from 2000 to 2022.

A prospective single-center, single-arm, open-label, phase II study of sintilimab and anlotinib combined with chemotherapy in neoadjuvant treatment of resectable esophageal cancer.

Background: Antiangiogenic treatment and immunochemotherapy effectively treat patients with advanced esophageal cancer. However, there remains a dearth of studies concerning neoadjuvant therapy for resectable esophageal cancer.

Methods: The study focused on patients with T2-4NxM0 resectable esophageal carcinoma.

Prognostic Model Construction of Disulfidptosis-Related Genes and Targeted Anticancer Drug Research in Pancreatic Cancer.

Pancreatic cancer stands as one of the most lethal malignancies, characterized by delayed diagnosis, high mortality rates, limited treatment efficacy, and poor prognosis. Disulfidptosis, a recently unveiled modality of cell demise induced by disulfide stress, has emerged as a critical player intricately associated with the onset and progression of various cancer types. It has emerged as a promising candidate biomarker for cancer diagnosis, prognosis assessment, and treatment strategies.

Coordinated dynamics of aquaculture ponds and water eutrophication owing to policy: A case of Jiangsu province, China.

Aquaculture ponds (APs) are rapidly expanding globally and are considered crucial for guaranteeing the supply of food, population growth, and economic development. However, the rapid expansion of aquaculture not only brought benefits but also a series of eco-environmental issues, such as water eutrophication. To achieve sustainable development, it is essential to gain a profound understanding of the spatiotemporal evolution of APs, the drivers behind their dynamics, and their relationship with the aquatic environment.

Characterization of a novel 3-quinuclidinone reductase possessing remarkable thermostability.

The 3-quinuclidinone reductase plays an irreplaceable role in the biopreparation of (R)-3-quinuclidinol, an intermediate vital for synthesis of various pharmaceuticals. Thermal robustness is a critical factor for enzymatic synthesis in industrial applications. This study characterized a new 3-quinuclidinone reductase, named SaQR, with significant thermal stability.

Characterization of a Novel Thermostable 7α-Hydroxysteroid Dehydrogenase.

Background: 7α-Hydroxysteroid dehydrogenase (7α-HSDH) plays a pivotal role in vivo in the biotransformation of secondary bile acids and has great potential in industrial biosynthesis due to its broad substrate specificity. In this study, we expressed and characterized a novel thermostable 7α-HSDH (named Sa 7α-HSDH).

Methods: The DNA sequence was derived from the black bear gut microbiome metagenomic sequencing data, and the coding sequence of Sa 7α-HSDH was chemically synthesized.

Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways.

Acute pancreatitis (AP) is a severe gastrointestinal inflammatory disease with increasing mortality and morbidity. Glycyrrhiza glabra, commonly known as Liquorice, is a widely used plant containing bioactive compounds like Glycyrrhizin, which possesses diverse medicinal properties such as anti-inflammatory, antioxidant, antiviral, and anticancer activities. The objective of this study is to investigate the active components, relevant targets, and underlying mechanisms of the traditional Chinese medicine Glycyrrhiza glabra in the treatment of AP.

Molecular subgroup establishment and signature creation of lncRNAs associated with acetylation in lung adenocarcinoma.

Background: The significance of long non-coding RNAs (lncRNAs) as pivotal mediators of histone acetylation and their influential role in predicting the prognosis of lung adenocarcinoma (LUAD) has been increasingly recognized. However, there remains uncertainty regarding the potential utility of acetylation-related lncRNAs (ARLs) in prognosticating the overall survival (OS) of LUAD specimens.

Methods: The RNA-Seq and clinical information were downloaded from The Cancer Genome Atlas (TCGA).

Mapping particulate organic carbon in lakes across China using OLCI/Sentinel-3 imagery.

Remote sensing monitoring of particulate organic carbon (POC) concentration is essential for understanding phytoplankton productivity, carbon storage, and water quality in global lakes. Some algorithms have been proposed, but only for regional eutrophic lakes. Based on in-situ data (N = 1269) in 49 lakes across China, we developed a blended POC algorithm by distinguishing Type-I and Type-II waters.

A novel strategy for estimating biomass of submerged aquatic vegetation in lake integrating UAV and Sentinel data.

Submerged aquatic vegetation (SAV) plays a fundamental ecological role in mediating carbon cycling within lakes, and its biomass is essential to assess the carbon sequestration potential of lake ecosystems. Remote sensing (RS) offers a powerful tool for large-scale SAV biomass retrieval. Given the underwater location of SAV, the spectral signal in RS data often exhibits weakness, capturing primarily horizontal structure rather than volumetric information crucial for biomass assessment.

Salinity is an important factor in carbon emissions from an inland lake in arid region.

Saline lakes, serving as the ultimate destination for most hydrological systems, accumulate substantial amounts of nutrients and organic matter from basins, and act as vast carbon reservoirs. These lakes exhibit exceptionally active biogeochemical cycling processes of carbon dioxide (CO) and methane (CH), and constitute integral components of the global carbon cycle. However, understanding of greenhouse gas emissions from saline lakes remains unclear mostly due to scarce data.

Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy.

The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells, immune cells, stromal cells, cytokines, and chemokines which together govern tumor progression and response to immunotherapies. Methyltransferase-like 3 (METTL3), a core catalytic subunit for RNA N-methyladenosine (mA) modification, plays a crucial role in regulating various physiological and pathological processes. Whether and how METTL3 regulates the TME and anti-tumor immunity in non-small-cell lung cancer (NSCLC) remain poorly understood.