Publications by authors named "HongPing Yu"
Background And Objective: In clinical practice, CK19 can be an important predictor for the prognosis of HCC. Due to the high incidence and mortality rates of HCC, more effective and practical prognostic prediction models need to be developed urgently.
Methods: A total of 1,168 HCC patients, who underwent radical surgery at the Guangxi Medical University Cancer Hospital, between January 2014 and July 2019, were recruited, and their clinicopathological data were collected.
This study profiled global single cell-spatial-bulk transcriptome landscapes of hepatocellular carcinoma (HCC) ecosystem from six HCC cases and a non-carcinoma liver control donor. We discovered that intratumoral heterogeneity mainly derived from HCC cells diversity and pervaded the genome-transcriptome-proteome-metabolome network. HCC cells are the core driving force of taming tumor-associated macrophages (TAMs) with pro-tumorigenic phenotypes for favor its dominant growth.
View Article and Find Full Text PDFThe Chitinase 3-like protein 1 (CHI3L1) is currently used as a biomarker for the diagnosis of liver fibrosis. However, its prognostic value for hepatocellular carcinoma (HCC) patients remains controversial. In this study, we aimed to investigate the prognostic value of the CHI3L1 in HCC patients after hepatectomy.
View Article and Find Full Text PDFArticle Synopsis
- Familial hypercholesterolemia (FH) is a genetic disorder mainly caused by mutations in the LDLR gene, specifically identifying two pathogenic mutations: c.G1027A (p.Gly343Ser) and c.G1879A (p.Ala627Thr).
- Whole exome sequencing was used to identify mutations in FH patients, followed by Sanger sequencing in their family members to analyze genetic correlations and evaluate LDLR expression using various cell assays.
- Results showed p.Gly343Ser had normal protein localization, while p.Ala627Thr exhibited decreased expression and cytoplasmic localization, with bioinformatics indicating possible impacts on post-translational modifications affecting protein levels.
Article Synopsis
- Alport syndrome (AS) is a genetic disorder leading to end-stage renal disease, often misdiagnosed, and the study focused on three Chinese families exhibiting nephrotic syndrome (NS) as a key symptom.
- Genetic testing revealed three significant mutations in the COL4A5 gene associated with X-linked Alport syndrome, highlighting their role in causing kidney issues.
- The findings suggest that some individuals may primarily present with nephrotic syndrome, expanding the understanding of how Alport syndrome manifests in patients.
Article Synopsis
- N-methyladenosine (mA) is a key modification involved in various biological processes, including cancer progression, prompting researchers to study its genetic variants' impact on survival in liver cancer related to hepatitis B.
- A two-stage survival analysis was conducted on 4425 SNPs from 36 mA modification genes, revealing two significant variants (METTL3 rs1263790 and ADARB1 rs57884102) that correlate with overall survival in HBV-HCC patients.
- Results suggest that the presence of certain risk genotypes negatively affects survival, and the findings support further investigation into these genetic variants as potential indicators for prognosis in HBV-HCC.
Cell-to-cell mitochondrial transfer has recently been shown to play a role in maintaining physiological functions of cell. We previously illustrated that mitochondrial transfer within osteocyte dendritic network regulates bone tissue homeostasis. However, the mechanism of triggering this process has not been explored.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the link between genetic variants in the p53 signaling pathway and survival rates in patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC), focusing on 4698 single nucleotide polymorphisms (SNPs) across 70 genes.
- - Researchers discovered two specific SNPs, rs7925603 A > G and rs4396625 A > T, which significantly affect overall survival outcomes for HBV-HCC patients, suggesting that these variants may alter mRNA expression levels.
- - The findings highlight the need for larger studies to further validate the role of these SNPs in influencing survival in HBV-HCC, as they may provide insights into cancer prognosis and treatment strategies.
Recessive congenital methemoglobinemia (RCM) is a hereditary autosomal disorder with an extremely low incidence rate. Here, we report a case of methemoglobinemia type I in a patient with congenital persistent cyanosis. The condition was attributed to a novel compound heterozygous mutation in CYB5R3, characterized by elevated methemoglobin levels (13.
View Article and Find Full Text PDFIntroduction: We previously reported that ATP1A3 c.823G>C (p.Ala275Pro) mutant causes varying phenotypes of alternative hemiplegia of childhood and rapid-onset dystonia-parkinsonism in the same family.
View Article and Find Full Text PDFWasp venom injections from wasp stings can damage several organs, most commonly the kidneys. Despite literature evidence, wasp sting-induced acute kidney injury (AKI) is rare and involves complex pathophysiological processes. While acute tubular necrosis (ATN) is the most prevalent histological result of wasp sting-induced AKI, uncommon combinations of chronic renal lesions have been described, alerting us to the patient's underlying illness.
View Article and Find Full Text PDFBackground: The nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes involved in the pathogenesis of several cancers, including hepatocellular carcinoma (HCC). However, the effects of genetic variants in the NLRP3 inflammasome-related genes on survival of hepatitis B virus (HBV)-related HCC patients are unclear.
Methods: We performed multivariable Cox proportional hazards regression analysis to evaluate associations between 299 single-nucleotide polymorphisms (SNPs) in 16 NLRP3 inflammasome-related genes and overall survival (OS) of 866 patients with HBV-related HCC.
Background: Primary ciliary dyskinesia (PCD) is an autosomal recessive hereditary disease characterized by recurrent respiratory infections. In clinical manifestations, DNAH5 (NM_001361.3) is one of the recessive pathogenic genes.
View Article and Find Full Text PDFBackground: Potentially modifiable risk factors for hepatocellular carcinoma (HCC) have been investigated in observational epidemiology studies in East Asian and European populations, whereas the causal associations of most of these risk factors remain unclear.
Methods: We collected genome-wide association summary statistics of 22 modifiable risk factors in East Asians and 33 risk factors in Europeans. Genetic summary statistics of HCC were sourced from the Biobank Japan study (1,866 cases and 195,745 controls) for East Asians, and the deCODE genetics study (406 cases and 49,302 controls) and the UK Biobank (168 cases and 372 016 controls) for Europeans.
Article Synopsis
- - The study investigates a nonclassical form of Cholesterol Ester Storage Disorder (CESD) that appears to be inherited in an autosomal dominant manner, contrary to previous beliefs about it being autosomal recessive due to mutations in the LIPA gene, which affects lysosomal acid lipase (LAL) activity.
- - Researchers analyzed a Chinese family with 15 members, finding that four living relatives displayed reduced LAL activity and liver dysfunction, while four deceased members likely died from liver failure linked to the disorder.
- - Genetic analysis identified a new heterozygous mutation (c.1133T>C) in the LIPA gene among the living family members, suggesting a potential link between this mutation and the nonclass
Background: Although the Notch pathway plays an important role in formation and progression of hepatocellular carcinoma (HCC), few studies have reported the associations between functional genetic variants and the survival of hepatitis B virus (HBV)-related HCC.
Methods: In the present study, we performed multivariable Cox proportional hazard regression analysis to evaluate associations between 36,101 SNPs in 264 Notch pathway-related genes and overall survival (OS) of 866 patients with HBV-related HCC.
Results: It was found that three independent SNPs (NEURL1B rs4868192, CNTN1 rs444927 and FCER2 rs1990975) were significantly associated with the HBV-related HCC OS.
Article Synopsis
- - Gaucher disease (GD) is a rare genetic disorder caused by a deficiency of the enzyme glucocerebrosidase due to mutations in the GBA1 gene, resulting in symptoms affecting multiple organs, particularly the liver, spleen, and bone marrow.
- - An adult male in China experienced severe splenic enlargement and related symptoms for 13 years, with his Gaucher disease diagnosis being delayed until a splenectomy revealed splenic Gaucher disease, highlighting the need for better awareness of rare diseases among healthcare providers.
- - Genetic analysis identified two mutations in the GBA1 gene in the patient, including a previously unreported one, which may disrupt protein structure and contribute to his non-neuronopathic type of Gau
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a high mortality rate. The 5-methylcytosine (m5C), a type of RNA modification, plays crucial regulatory roles in HCC carcinogenesis, metastasis, and prognosis. However, a few studies have investigated the effect of genetic variants in m5C modification genes on survival of patients with hepatitis B virus (HBV)-related HCC.
View Article and Find Full Text PDFDisulfidptosis is a novel form of programmed cell death involved in migration and invasion of cancer cells, but few studies investigated the roles of genetic variants in disulfidptosis-related genes in survival of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). We used Cox proportional hazards regression analyses, Kaplan-Meier curves and receiver operating characteristic curves to assess effects of genetic variants in 14 disulfidptosis-related genes on overall survival of 866 HBV-HCC patients. The Bayesian false discovery probability was used for multiple testing corrections.
View Article and Find Full Text PDFBackground: Although the sphingolipid metabolism pathway is known to play a significant role in tumor progression, there have been few studies on how genetic variants in the sphingolipid metabolism pathway genes affect the survival of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Methods: We utilized available genotyping data to conduct multivariate Cox proportional hazards regression model analysis, examining the associations of 12,188 single nucleotide polymorphisms (SNPs) in 86 sphingolipid metabolism pathway genes on the survival of 866 HBV-HCC patients, and the model was also used in additive interaction analysis. We used bioinformatics functional prediction and expression quantitative trait locus (eQTL) analysis to explore the potential functions of SNPs and to evaluate the association of SNPs with the corresponding mRNA expression, respectively.
Purpose: Cytokeratin 19-positive cancer stem cells (CK19 + CSCs) and their tumor-associated macrophages (TAMs) have not been fully explored yet in the hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Experimental Design: Single-cell RNA sequencing was performed on the viable cells obtained from 11 treatment-naïve HBV-associated HCC patients, including 8 CK19 + patients, to elucidate their transcriptomic landscape, CK19 + CSC heterogeneity, and immune microenvironment. Two in-house primary HCC cohorts (96 cases-related HBV and 89 cases with recurrence), TCGA external cohort, and in vitro and in vivo experiments were used to validate the results.
Background: Ferroptosis is a known crucial player in the development of cancers. However, the effect of single nucleotide polymorphisms (SNPs) in ferroptosis-related genes on survival in hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC) patients remains unknown.
Methods: We used two-stage multivariable Cox proportional hazards regression analyses to estimate the associations between 48,774 SNPs in 480 ferroptosis-related genes and overall survival (OS) of 866 HBV-HCC patients.
The nuclear factor E2-related factor 2 (NRF2) signaling pathway is one of the most important cell defense pathways. However, it is unclear whether genetic variants in NRF2 signaling pathway genes are associated with the survival of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). In the present study, we utilized a new hypothesis-driven approach based on biological pathways to investigate the associations between 17919 single nucleotide polymorphisms (SNPs) in 137 NRF2 signaling pathway genes and the overall survival (OS) of 866 patients with HBV-related HCC.
View Article and Find Full Text PDFObservational studies have reported associations between circulating biomarkers related to cardiovascular disease and the survival of patients with hepatocellular carcinoma. However, the relationship between these biomarkers and survival remains controversial. We conducted a two-sample Mendelian randomization analysis to investigate possible causal associations between cardiovascular disease biomarkers and hepatocellular carcinoma survival.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the outcomes of radiation-induced hepatic toxicity (RIHT) in patients with hepatocellular carcinoma (HCC) receiving radiotherapy (RT) combined with anti-PD1 antibodies versus RT alone, and to identify factors predicting non-classic radiation-induced liver disease (ncRILD).
- Patients with unresectable HCC were retrospectively analyzed, with 30 receiving RT plus anti-PD1 and 66 receiving RT alone, using propensity score matching to ensure comparability.
- Results indicated similar RIHT rates between the two groups, with a higher frequency of elevated AST levels in the RT + PD1 group after matching; a nomogram was developed based on factors such as tumor number and patient age,