The Evaluation of Right Ventricular Synchrony by Two-Dimensional Speckle Tracking Echocardiography in Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.

Objectives: Numerous studies have demonstrated impaired right ventricular (RV) synchronicity in pulmonary arterial hypertension (PAH). However, few studies have focused on connective tissue disease (CTD)-associated PAH. This study evaluates RV dyssynchrony and its prognostic value in CTD-associated PAH.

Metagenomic Insights into Coal Slag Remediation Effects on Soil and Microbial Health in Qinghai's Muli Coal Mine.

Long-term coal mining in the Muli coal mine area of Qinghai Province has degraded soil quality and reduced microbial diversity, making it imperative to implement effective ecological restoration measures to restore soil quality and enhance ecosystem functions. This study evaluated soil samples under 11 ecological restoration treatments using metagenomic sequencing combined with soil quality analysis to explore the responses of the microbial community structure and function to identify effective restoration measures. This study demonstrated that ecological restoration significantly increased the soil microbial diversity and richness, with the MLII1 (soil samples treated with a chemical weathering agent, attapulgite, and a microbial agent) and MLIII1 (soil samples treated with sheep manure (2.

ACuGaS (A = Rb, Cs): Design and Synthesis of Two New Cavity-Chalcopyrite Chalcogenides Based on "Iterative Substitution" Strategy.

Two new non-centrosymmetric chalcogenides, ACuGaS (A=Rb, Cs) have been successfully synthesized by an "iterative substitution" strategy based on chalcopyrite CuFeS structural template. Benefiting from the substitution of Fe cations by Ga cations, ACuGaS (A = Rb, Cs) exhibit wide suitable band gap of 2.48 and 2.

BaGeFQ (Q = S, Se) and BaGeFSe: new F-based chalcohalides with enhanced birefringence.

Three new F-based chalcohalides, BaGeFQ (Q = S, Se) and BaGeFSe, have been successfully synthesized. On going from BaGeFSe (Δ = 0.063@1064 nm) to BaGeFQ (Q = S, Se) (Δ = 0.

Reticular chemistry-aided effective design of new second-order nonlinear optical selenites.

Noncentrosymmetric (NCS) compounds are particularly important for modern optoelectronic technology, yet their rational structural design remains a great challenge. Herein, assisted by the idea of bottom-up reticular chemistry, seven new NCS selenites, AM[SeO][SeO] (A = K/Rb/Cs; M = Al/Ga/In), have been successfully designed and synthesized by assembling main-group metal octahedral units and SeO units, to construct honeycomb layers with regular channels to accommodate a variety of cations, and using planar hexagonal shapes to orientate the groups within the network. Based on this strategy, the overall symmetry of the solid-state compounds was effectively controlled, and by modifying locally connected atoms or groups, without disrupting the overall prototypical framework, a series of iso-reticular analogues have been obtained, which greatly increases the probability of NCS structures.

Ae[TO][SnOQ] (Ae = Sr, Ba; T = Si, Ge; Q = S, Se) and Ba[CO][MQ] (M = Ge, Sn; Q = S, Se): Design and Syntheses of a Series of Heteroanionic Antiperovskite-Type Oxychalcogenides.

The heteroanionic materials (HAMs) have attracted more and more attention because they can better balance the functional properties of materials. However, their rational structural design is still a great challenge. Here, by using the antiperovskite BaS[GeS] as a template and calculating the tolerance factor () as a reference, eight heteroanionic oxychalcogenides with balanced properties were finally synthesized by a partially group-substitution method.

KY(BO): A Potential UV Nonlinear-Optical Crystal Designed by a Chemical Substitution Strategy.

Nonlinear-optical (NLO) crystals capable of controlling and manipulating light to generate coherent radiation at challenging wavelengths are of significant interest. However, designing a new UV NLO crystal remains difficult due to the rigid requirements for structure and properties. Herein, we have successfully designed and synthesized a novel noncentrosymmetric (NCS) rare-earth borate UV NLO crystal, KY(BO), through the heterovalence substitution of YAl(BO).

BaScBSiO: A Mixed-Coordination Borosilicate with a Low B/Si Ratio Exhibiting Enhanced Second Harmonic Generation Response.

Rational chemical substitution is an effective way to regulate structure and enrich property. Herein, a new noncentrosymmetric borosilicate, BaScBSiO, was successfully synthesized by substituting CaO units in BaCaBSiO with ScO octahedra, with comparatively strong covalency. This substitution not only effectively prevents polymerization of the B-O groups, resulting in an intriguing structural transformation from tetrahedral-coordinated borosilicate of BaCaBSiO to mixed-coordinated borosilicate BaScBSiO, but also enhances its second harmonic generation response (2 × KDP), that is nearly four times higher than its parent structure while keeping a short ultraviolet (UV) cutoff edge (λ < 190 nm).

LaGaMSnO, (M = Ge, Si): Design and Synthesis of Two Langasite Nonlinear Optical Materials with Large Second Harmonic Generation and Birefringence Induced by Distorted (Sn/M)O Octahedra.

Nonlinear optical (NLO) coherent light sources are widely applied in many areas of science and technology. As the core medium, the NLO material is required to have a wide transparent range, a large NLO response, and a high laser damaged threshold (LDT). It is common knowledge that langasite (LaGaSiO, LGS) crystal has an underdeveloped second-harmonic generation (SHG) coefficient and a small birefringence, which seriously restrict its application in the NLO field, despite that it has a broad transmittance spectrum and a moderate LDT.

Assembly of π-Conjugated [BO] Units by Mer-Isomer [YOF] Octahedra to Design a UV Nonlinear Optical Material, CsYBOF.

Achieving the extreme balance of the key performance requirements is the crucial to breakthrough the application bottleneck for nonlinear optical (NLO) materials. Herein, by assembly of the π-conjugated [BO] functional species with the aid of structure-directing property of mer-isomer [YOF] octahedra, a new ultraviolet (UV) NLO material, CsYBOF with aligned arrangement of coplanar [BO] groups has been synthesized. The polar material exhibits the rare coexistence of the largest second harmonic generation response of 5.

LaMgGaS: a chemical stable divalent lanthanide chalcogenide.

Divalent lanthanide inorganic compounds can exhibit unique electronic configurations and physicochemical properties, yet their synthesis remains a great challenge because of the weak chemical stability. To the best of our knowledge, although several lanthanide monoxides epitaxial thin films have been reported, there is no chemically stable crystalline divalent lanthanide chalcogenide synthesized up to now. Herein, by using octahedra coupling tetrahedra single/double chains to construct an octahedral crystal field, we synthesized the stable crystalline La(II)-chalcogenide, LaMgGaS.

Pb[OPb](SiO)X (X = Cl, Br): The First Pb-Containing Halogen Silicates with Mirror-Symmetric Pseudo-Aurivillius Bilayers.

Two new congruently melting Pb-containing halogen silicates, Pb[OPb](SiO)X (X = Cl, Br), have been synthesized using a high-temperature solution method. Their crystal structures were determined by single-crystal X-ray diffraction, and both compounds crystallize in the orthorhombic space group . In both structures, the mirror-symmetric bilayer composed of Pb-O polyhedra is observed for the first time in Pb-containing silicates and belongs to α-PbO derivatives and is related to the Aurivillius phase.

CsIn(InSe)(PSe): A Multi-Chromophore Chalcogenide with Excellent Nonlinear Optical Property Designed by Group Grafting.

Non-centrosymmetric (NCS) and polar materials capable of exhibiting many important functional properties are indispensable for electro-optical technologies, yet their rational structural design remains a significant challenge. Here, we report a "group grafting" strategy for designing the first multi-chromophore selenophosphate, CsIn(InSe)(PSe), that crystallizes in a NCS and polar space group of Cm. The structure features a unique basic building unit (BBU) [In(InSe)(PSe)], formed through "grafting [InSe] supertetrahedra on the root of [In(PSe)] groups".

From NaGa(IO)F to NaGa(IO)F and NaGa(IO): The Effects of Chemical Substitution between F Anions and IO Groups on the Structures and Properties of Gallium Iodates.

Introducing F anions or substituting F anions with IO groups has been proven to be ideal strategies for designing novel noncentrosymmetric (NCS) and polar materials, yet systematic investigation into the effect of F anions or the substitution of IO for F anions on structures and properties remains rarely explored. Herein, two new gallium iodates, NaGa(IO)F () and NaGa(IO) (), were successfully designed and synthesized based on NaGa(IO)F by introducing more F anions and replacing F anions with IO groups, respectively. Structurally, in compound , the adjacent [GaF(IO)] polyanions are connected in an antiparallel manner, resulting in a complete cancellation of local polarity.

Chiral and Polar Duality Design of Heteroanionic Compounds: Sr Ge O S Based on [Sr OGeS ] and [Sr SGeS ] Groups.

Chirality and polarity are the two most important and representative symmetry-dependent properties. For polar structures, all the twofold axes perpendicular to the principal axis of symmetry should be removed. For chiral structures, all the mirror-related symmetries and inversion axes should be removed.

Factors influencing the distribution of woody plants in tropical karst hills, south China.

The seasonal rainforests distributed across the tropical karst hills of south China are of high biodiversity conservation value and serve many important ecosystem functions. However, knowledge surrounding distribution patterns of woody plants in tropical karst hills remains limited. In this study, we surveyed the distribution of families, genera and species of woody flora at four slope positions (depression, lower slope, middle slope, and upper slope), and analyzed the influence of topographic and soil variables on the distribution of woody plants in the tropical karst hills of south China.

The preliminary in vitro study and application of deep learning algorithm in cone beam computed tomography image implant recognition.

To properly repair and maintain implants, which are bone tissue implants that replace natural tooth roots, it is crucial to accurately identify their brand and specification. Deep learning has demonstrated outstanding capabilities in analysis, such as image identification and classification, by learning the inherent rules and degrees of representation of data models. The purpose of this study is to evaluate deep learning algorithms and their supporting application software for their ability to recognize and categorize three dimensional (3D) Cone Beam Computed Tomography (CBCT) images of dental implants.

Image classification and auxiliary diagnosis system for hyperpigmented skin diseases based on deep learning.

Background And Aim: Melasma (ML), naevus fusco-caeruleus zygomaticus (NZ), freckles (FC), cafe-au-lait spots (CS), nevus of ota (NO), and lentigo simplex (LS), are common skin diseases causing hyperpigmentation. Deep learning algorithms learn the inherent laws and representation levels of sample data and can analyze the internal details of the image and classify it objectively to be used for image diagnosis. However, deep learning algorithms that can assist clinicians in diagnosing skin hyperpigmentation conditions are lacking.

CD24LCN2 liver progenitor cells in ductular reaction contributed to macrophage inflammatory responses in chronic liver injury.

Background: CD24CK19/CD24SOX9 resident liver cells are activated and expanded after chronic liver injury in a ductular reaction. However, the sources and functions of these cells in liver damage remain disputed.

Results: The current study combined genetic lineage tracing with in vitro small-molecule-based reprogramming to define liver progenitor cells (LPCs) derived from hepatic parenchymal and non-parenchymal tissues.

LiGa(IO ) : An Excellent NLO Material with Unprecedented 2D [Ga(IO ) ] Layer Synthesized by Aliovalent Substitution.

Nonlinear optical (NLO) crystals are indispensable for the solid-state lasers for their ability to expand wavelength spectral to the regions where the directing lasing is difficult or even impossible, yet the rational design of a high-performance NLO crystal remains a great challenge owing to the severe structural and properties' requirements. Herein, a new noncentrosymmetric (NCS) and polar gallium iodate, LiGa(IO ) , with a novel 2D anionic layer, is successfully designed and synthesized by the aliovalent substitution strategy based on classic α-LiIO . The 2D [Ga(IO ) ] layer in LiGa(IO ) is built from the GaO octahedra and highly polarizable units IO .

Remodeling of the 3D chromatin architecture in the marine microalga Nannochloropsis oceanica during lipid accumulation.

Background: Genomic three-dimensional (3D) spatial organization plays a key role in shaping gene expression and associated chromatin modification, and it is highly sensitive to environmental stress conditions. In microalgae, exposure to nitrogen stress can drive lipid accumulation, yet the associated functional alterations in the spatial organization of the microalgal genome have yet to be effectively characterized.

Results: Accordingly, the present study employed RNA-seq, Hi-C, and ChIP-seq approaches to explore the relationship between 3D chromosomal architecture and gene expression during lipid accumulation in the marine microalga Nannochloropsis oceanica in response to nitrogen deprivation (ND).

A novel cationic covalent organic framework as adsorbent for simultaneous removal of methyl orange and hexavalent chromium.

The simultaneous removal of toxic, carcinogenic organic dyes and metal ions from water by one material offers significant advantages when fast, facile, and robust water purification is required. Ionic covalent organic frameworks (ICOFs) have the combined properties of COFs and ion exchange resins and are expected to achieve simultaneous capture of heavy metal ions and organic dyes from water. Herein, a novel guanidinium-based ICOF was synthesized using a solvothermal method.

[Ba (S )][ZnGa S ]: Design of an Unprecedented Infrared Nonlinear Salt-Inclusion Chalcogenide with Disulfide-Bonds.

Salt-inclusion chalcogenides (SICs) have been receiving widespread attention due to their large second harmonic generation (SHG) responses and wide bandgaps, however most of them suffer from small birefringence limiting their technical application. Herein, by introducing the π-conjugated (S ) units in the ionic guest of salt-inclusion structure, the first disulfide-bond-containing SIC, [Ba (S )][ZnGa S ] has been synthesized. It exhibits the widest bandgap up to 3.