Flexible piezoelectric nanogenerators based on a CdS nanowall for self-powered sensors.

Wurtzite-structured CdS material is widely used in information sensing and energy harvesting. Based on the piezoelectric property of CdS, we present a flexible piezoelectric nanogenerator (PENG) with three-dimensional-structured CdS nanowall arrays. Under index finger oscillations at a slow rate, the maximal open-circuit voltage and short-circuit current are 1.

Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide.

Background: Accumulating public health and epidemiological literature support the hypothesis that arsenic in drinking water or food affects the brain adversely.

Methods: Experiments on the consequences of nitric oxide (NO) formation in neuronal cell culture and mouse brain were conducted to probe the mechanistic pathways of nitrosative damage following arsenic exposure.

Results: After exposure of mouse embryonic neuronal cells to low doses of sodium arsenite (SA), we found that Ca was released leading to the formation of large amounts of NO and apoptosis.

Investigation of the Effects of Squalene and Squalene Epoxides on the Homeostasis of Coenzyme Q10 in Rats by UPLC-Orbitrap MS.

Squalene has been used as a dietary supplement for a long history due to its potential cancer-preventive function. However, the mechanism has not been investigated in detail yet. Therefore, the aim of this study is to see if the plasma coenzyme Q10 (CoQ10) level will be altered by gavage of squalene and oxidosqualenes to rats.

Solid and Hematologic Neoplasms After Testicular Cancer: A US Population-Based Study of 24 900 Survivors.

Background: No large US population-based study focusing on recent decades, to our knowledge, has comprehensively examined risks of second malignant solid and hematological neoplasms (solid-SMN and heme-SMN) after testicular cancer (TC), taking into account initial therapy and histological type.

Methods: Standardized incidence ratios (SIR) vs the general population and 95% confidence intervals (CI) for solid-SMN and heme-SMN were calculated for 24 900 TC survivors (TCS) reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results registries (1973-2014). All statistical tests were two-sided.

Metabolic syndrome associated with the onset of depressive symptoms among women but not men in rural Northeast China.

Background: The present study aimed to assess the cumulative incidence of major depressive disorder (MDD) among rural Chinese residents. Furthermore, we intended to estimate whether metabolic syndrome (MetS) was associated with MDD by both cross-sectional and prospective analysis.

Method: Data of 11,675 residents (46.

The unidirectional causality influence of factors on PM in Shenyang city of China.

Air quality issue such as particulate matter pollution (PM and PM) has become one of the biggest environmental problem in China. As one of the most important industrial base and economic core regions of China, Northeast China is facing serious air pollution problems in recent years, which has a profound impact on the health of local residents and atmospheric environment in some part of East Asia. Therefore, it is urgent to understand temporal-spatial characteristics of particles and analyze the causality factors.

T integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection.

Tissue-resident memory CD8 T (T) cells are a unique immune memory subset that develops and remains in peripheral tissues at the site of infection, providing future host resistance upon reexposure to that pathogen. In the pulmonary system, T are identified through S1P antagonist CD69 and expression of integrins CD103/β7 and CD49a/CD29(β1). Contrary to the established role of CD69 on CD8 T cells, the functions of CD103 and CD49a on this population are not well defined.

Downregulation of ubiquitin-specific protease 2 possesses prognostic and diagnostic value and promotes the clear cell renal cell carcinoma progression.

Background: Clear cell renal cell carcinoma (ccRCC), characterized by high mortality, invasion, metastasis, recurrence and drug resistance, is the most common malignant tumor of the urinary system. A clear understanding of the underlying molecular mechanisms and its role during tumorigenesis of RCC can contribute to development of prognostic and targeted therapies.

Methods: We analyzed datasets from the public database, TCGA, Oncomine, for differential expression of ubiquitin-specific protease 2 (USP2), and further investigated its relationship with the clinical stage, pathological grade and prognosis of renal cancer.

Mechanistic study of cellobiose conversion to 5-hydroxymethylfurfural catalyzed by a Brønsted acid with counteranions in an aqueous solution.

The fundamental understanding of the cooperativity of a Brønsted acid together with its anion for cellulose conversion in an aqueous solution is limited at present, in which cellobiose has usually been regarded as a bridge that connects monosaccharides and cellulose. The mechanism of β-cellobiose conversion to 5-hydroxymethylfurfural (HMF) catalyzed by a Brønsted acid (HO) accompanied by counteranions in an aqueous solution has been studied using quantum chemical calculations at the M06-2X/6-311++G(d,p) level under a polarized continuum model (PCM-SMD). For the formation of the first HMF from cellobiose, there are three reaction pathways, i.

HSD17B4, ACAA1, and PXMP4 in Peroxisome Pathway Are Down-Regulated and Have Clinical Significance in Non-small Cell Lung Cancer.

To explore the potential functions and clinical significances of peroxisomes during lung cancer development and progression, we investigated the expressional profiles of peroxisome pathway genes and their correlations with clinical features in non-small cell lung cancer (NSCLC). The RNA-seq data of NSCLC including lung squamous carcinoma (LUSC) and lung adenocarcinoma (LUAD) patients with their clinical information were downloaded from The Cancer Genome Atlas (TCGA). Gene expression comparisons between tumor and normal samples were performed with edgeR package in R software and the results of the 83 peroxisome pathway genes were extracted.

Peroxiredoxins and Immune Infiltrations in Colon Adenocarcinoma: Their Negative Correlations and Clinical Significances, an In Silico Analysis.

: Peroxiredoxins (PRDXs) were reported to be associated with inflammation response in previous studies. In colon adenocarcinoma (COAD), however, their correlations and clinical significance were unclear. : The RNA-seq data of 452 COAD patients with clinical information was downloaded from The Cancer Genome Atlas (TCGA) and transcripts per million (TPM) normalized.

IMPDH1/YB-1 Positive Feedback Loop Assembles Cytoophidia and Represents a Therapeutic Target in Metastatic Tumors.

Recently, cytoophidium, a nonmembrane-bound intracellular polymeric structure, has been shown to exist in various organisms, including tumor tissues, but its function and mechanism have not yet been examined. Examination of cytoophidia-assembled gene inosine monophosphate dehydrogenase (IMPDH) and cytidine triphosphate synthetase (CTPS) mRNA levels showed that only IMPDH1 levels were significantly higher in the clear cell renal cell carcinoma (ccRCC). IMPDH1 was positively correlated with the metastasis-related gene Y-box binding protein 1 (YB-1) and served as an independent prognostic factor in ccRCC.

Are there differences in pain intensity between two consecutive vaginal childbirths? A retrospective cohort study.

Background: Pain assessment is crucial for in-labour pain management. Even though women's self-rated pain intensity is the standard for pain relief or analgesic administration, multiparas appear to receive worse in-labour pain management than primiparas do. The discrepancy in pain perception between primiparas and multiparas remains unclear.

Cathode Photoelectrochemical Paper Device for microRNA Detection Based on Cascaded Photoactive Structures and Hemin/Pt Nanoparticle-Decorated DNA Dendrimers.

In this work, a lab-on-paper cathode photoelectrochemical (PEC) sensing platform was constructed for ultrasensitive microRNA-141 (miRNA-141) assay using cascaded multiple photo-active structures as signal generators and hemin/Pt nanoparticle (Pt NP) trunk-branching-decorated DNA dendrimers as signal reinforcers. Specifically, pyramid-like CuO was first in situ grown on the Au nanoparticle-functionalized tangled cellulose fibers network, followed by the sensitization of trepang-like BiVO-BiS heterostructures, forming the cascaded sensitization structures. Then, the DNA dendrimer was introduced into the photocathode sensing interface by coupling the duplex-specific-nuclease (DSN)-induced target recycling reaction with multiple-branched hybridization chain reaction (MHCR).

Polydirectional Microvibration Energy Collection for Self-Powered Multifunctional Systems Based on Hybridized Nanogenerators.

Vibrations in the environment are usually distributed over a wide frequency spectrum in multiple directions and a weaker amplitude, which makes most of the current vibrational energy collectors limited in practical environmental applications. Herein, a triboelectric-electromagnetic hybridized nanogenerator (TEHG) for low-frequency random microvibrational energy harvesting in all directions and a wide working bandwidth is fabricated. The output peak power of a triboelectric nanogenerator (TENG) up to 3.

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese.

Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China.

Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54 ± 10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods.

ISG20 serves as a potential biomarker and drives tumor progression in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies and lacks reliable biomarkers for diagnosis and prognosis, which results in high incidence and mortality rates of ccRCC. In this study, ISG20, HJURP, and FOXM1 were identified as hub genes via weighted gene co-expression network analysis (WGCNA) and Cox regression analysis. Samples validation showed that only ISG20 was up-regulated in ccRCC.

Overexpression of PPT2 Represses the Clear Cell Renal Cell Carcinoma Progression by Reducing Epithelial-to-mesenchymal Transition.

Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors of the urinary system and has a poor response to radiotherapy and chemotherapy. To date, it is urgent to find effective biomarkers for the prevention and treatment of ccRCC. The occurrence and development of ccRCC is closely related to metabolic disturbances.

Diversity and space-time dynamics of the bacterial communities in cotton () rhizosphere soil.

Rhizosphere bacteria are key determinants of plant health and productivity. In this study, we used PCR-based next-generation sequencing to reveal the diversity and community composition of bacteria in the cotton rhizosphere from samples collected in Xinjiang Province, China. We identified 125 bacterial classes within 49 phyla from these samples.

Reducing Fluoroquinolone Use and Clostridioides difficile Infections in Community Nursing Homes Through Hospital-Nursing Home Collaboration.

Objective: Nursing homes (NHs) are an important target for antibiotic stewardship (AS). We describe a collaborative model to reduce Clostridioides difficile infections (CDIs) in NHs through optimization of antibiotic use including a reduction in high-risk antibiotics such as fluoroquinolones.

Design: Quasi-experimental, pre- and post-intervention study.

Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-resistant Prostate Cancer.

Purpose: Emerging evidence indicates that castration-resistant prostate cancer (CRPC) is often driven by constitutively active androgen receptor (AR) or its V7 splice variant (AR-V7) and commonly becomes resistant to endocrine therapy. The aim of this work is to evaluate the function of a kinesin protein, KIF4A, in regulating AR/AR-V7 in prostate cancer endocrine therapy resistance.

Experimental Design: We examined KIF4A expression in clinical prostate cancer specimens by IHC.

Prevalence and risk factors of prolonged corrected QT interval in general Chinese population.

Background: Corrected QT (QTc) interval has been correlated with total and CVD mortality. Although much is known about the relation between prolonged QTc interval and clinical outcome, there is no information on the prevalence and specific risk factors of QTc prolongation in general Chinese population. We evaluated the prevalence of prolonged QTc interval and its risk factors in general Chinese population, aiming to fill in the gaps in the literature and provide evidence for potential CVD risk prediction and disease burden estimate in community.

The screening of pivotal gene expression signatures and biomarkers in renal carcinoma.

Renal cell carcinoma (RCC) is one of the most common malignancies in the urinary system, among which the proportion of clear cell RCC (ccRCC) is over 80%. This study aims to explore potential signaling pathways and key biomarkers that drive RCC progression. The RCC GEO Datasets GSE15641 was featured to screen differentially expressed genes (DEGs).