Data Governance and Distribution of Biobank: A Case from a Chinese Cancer Hospital.

To facilitate the regionalization, specialization, and digitization of biobanks, three issues regarding data collection and application must be addressed (1) integration and distribution of data governance, (2) efficiency and efficacy of data governance, and (3) sustainability of data governance. We collaborated with stakeholders to identify priorities and assess infrastructure needs through the continuous evaluation and analysis of projects. We developed data management solutions, catalogs, and data models to optimize and support data collection, distribution, and application.

Over 10% Efficiency Pure Sulfide Kesterite Solar Cells on Transparent Electrode with Cd-Ag Co-Alloying.

The environmentally friendly elements composed of high bandgap pure sulfide CuZnSnS (CZTS) semiconductor has broad prospects for building integrated photovoltaic, double-sided, and semi-transparent solar cells when fabricated on transparent substrates. The key issues limiting the performance of CZTS solar cells are poor absorber quality and unfavorable band energy alignment causing serious charge carrier recombination. Here, thefabrication of CZTS solar cells are reported on fluorine-doped tin oxide (FTO) substrates from dimethyl sulfoxide solution and the effects of the Cd and Ag alloying on device performance.

Improving the performance of kesterite solar cells by solution germanium alloying.

Cation substitution is an effective strategy to regulate the defects/electronic properties of kesterite CuZnSn(S,Se) (CZTSSe) absorbers and improve the device photovoltaic performance. Here, we report Ge alloying kesterite CuZn(Sn,Ge)(S,Se) (CZTGSSe) a solution approach. The results demonstrate that the same chemical reaction of Ge to Sn ensures homogeneous Ge incorporation in the whole range of concentrations (from 0 to unit).

Self-Adaptive Rapid Thermal Conductive Fabrics Based on Hygroscopic Shrinkage Response for Personal Cooling and Drying.

Advanced fabrics with thermal wet management capability as low energy consumption media contribute to personal cooling and drying. Nevertheless, it remains a great challenge to obtain intelligent fabrics with adjustable thermal conductivity (TC) capable of bridging the supply and demand between human body temperature and self-adaptive thermal conduction. Herein, we report hygroscopic-shrinkage nanofiber-based fabrics with excellent moisture sensitivity and significant volume shrinkage, which benefits the construction of high-density thermal conductive pathways by absorbing sweat, with a maximum sweat absorption rate reaching up to 1781%.

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development.

Macrophages are heterogeneous and play critical roles in development and disease, but their diversity, function, and specification remain inadequately understood during human development. We generated a single-cell RNA sequencing map of the dynamics of human macrophage specification from PCW 4-26 across 19 tissues. We identified a microglia-like population and a proangiogenic population in 15 macrophage subtypes.

Dynamic Dysregulation of the Triple Network of the Brain in Mild Traumatic Brain Injury and Its Relationship With Cognitive Performance.

A triple network model consisting of a default network, a salience network, and a central executive network has recently been used to understand connectivity patterns in cognitively normal versus dysfunctional brains. This study aimed to explore changes in the dynamic connectivity of triplet network in mild traumatic brain injury (mTBI) and its relationship to cognitive performance. In this work, we acquired resting-state functional magnetic resonance imaging (fMRI) data from 30 mTBI patients and 30 healthy controls (HCs).

A Graph Theory Study of Resting-State Functional MRI Connectivity in Children With Carbon Monoxide Poisoning.

Background: The effect of carbon monoxide (CO) poisoning on the topology of brain functional networks is unclear, especially in children whose brains are still developing.

Purpose: To investigate the topological alterations of the whole-brain functional connectome in children with CO poisoning and characterize its relationship with disease severity.

Study Type: Cross-sectional and prospective study.

Fuzzy model for quantitative assessment of the epidemic risk of African Swine Fever within Australia.

African Swine Fever (ASF) has spread rapidly across different continents since 2007 and caused huge biosecurity threats and economic losses. Establishing an effective risk assessment model is of great importance for ASF prevention, especially for those ASF-free countries such as Australia. With a vast territory and an economy heavily relying on primary industry, Australia faces a threat from the spread of ASF.

Imaging of glutamate in acute carbon monoxide poisoning using chemical exchange saturation transfer.

Aims: This study adopted the Glutamate Chemical Exchange Saturation Transfer (GluCEST) imaging technique to quantitatively analyze cranial glutamate and discussed the effectiveness of GluCEST values in identifying the pathogenesis of encephalopathy after CO poisoning.

Methods: The routine MRI and functional MRI scans of two cohorts of subjects (CO group, = 29; Control group, = 21) were performed. Between-group comparisons were conducted for GluCEST% in regions of interest (ROI), including the basal ganglia, the thalamus, the frontal lobe, the occipital lobe, the genu of corpus callosum, the cingulate gyrus, and the cuneus.

Analysis on topological alterations of functional brain networks after acute alcohol intake using resting-state functional magnetic resonance imaging and graph theory.

Aims: Alcohol consumption could lead to a series of health problems and social issues. In the current study, we investigated the resting-state functional brain networks of healthy volunteers before and after drinking through graph-theory analysis, aiming to ascertain the effects of acute alcohol intake on topology and information processing mode of the functional brain networks.

Materials And Methods: Thirty-three healthy volunteers were enrolled in this experiment.

Dynamic connectivity patterns of resting-state brain functional networks in healthy individuals after acute alcohol intake.

Aims: Currently, there are only a few studies concerning brain functional alterations after acute alcohol exposure, and the majority of existing studies attach more importance to the spatial properties of brain function without considering the temporal properties. The current study adopted sliding window to investigate the resting-state brain networks in healthy volunteers after acute alcohol intake and to explore the dynamic changes in network connectivity.

Materials And Methods: Twenty healthy volunteers were enrolled in this study.

Living biobank-based cancer organoids: prospects and challenges in cancer research.

Biobanks bridge the gap between basic and translational research. Traditional cancer biobanks typically contain normal and tumor tissues, and matched blood. However, biospecimens in traditional biobanks are usually nonrenewable.

Flexible Organic Framework-Based Anthracycline Prodrugs for Enhanced Tumor Growth Inhibition.

A water-soluble flexible organic framework of low cytotoxicity has been synthesized from a pyridinium-derived tetracationic tetraaldehyde and a citric acid-derived tritopic acylhydrazine (1:2) through the formation of a hydrazone bond. Dynamic light-scattering experiments reveal that has a hydrodynamic diameter of 79 nm at 0.1 mM concentration of the tetrahedral precursor.

Abnormal Brain Functional Network Dynamics in Acute CO Poisoning.

Carbon monoxide poisoning is a common condition that can cause severe neurological sequelae. Previous studies have revealed that functional connectivity in carbon monoxide poisoning is abnormal under the assumption that it is resting during scanning and have focused on studying delayed encephalopathy in carbon monoxide poisoning. However, studies of functional connectivity dynamics in the acute phase of carbon monoxide poisoning may provide a more insightful perspective for understanding the neural mechanisms underlying carbon monoxide poisoning.

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Common fragile sites (CFSs) are specific breakage-prone genomic regions and are present frequently in cancer cells. The (E2-independent) E3 ubiquitin-conjugating enzyme FATS (fragile site-associated tumor suppressor) has antitumor activity in cancer cells, but the function of FATS in immune cells is unknown. Here, we report a function of FATS in tumor development via regulation of tumor immunity.

Two novel truncating variants in UBAP1 are responsible for hereditary spastic paraplegia.

Hereditary spastic paraplegias (HSPs) are a group of rare neurodegenerative disorders. HSPs are complex disorders and are clinically and genetically heterogeneous. To date, more than 80 genes or genetic loci have been reported to be responsible for HSPs in a Mendelian-dependent manner.

Exploring Deep-UV Nonlinear Optical Materials with Enhanced Second Harmonic Generation Response and Birefringence in Fluoroaluminoborate Crystals.

Deep-UV (DUV) nonlinear optical (NLO) materials are of vital importance to demanding DUV laser applications; however, those with a large NLO coefficient, wide band gap, and sufficient phase-matching ability are rare. In this work, by combining π-conjugated BO groups and distort AlOF tetrahedra, we successfully designed and synthesized two fluoroaluminoborates, RbAlBOF (RABF) and CsRbAlBOF (CRABF). In addition, the solid solution CsRbAlBOF (0.

Olive-Shaped Organic Cages: Synthesis and Remarkable Promotion of Hydrazone Condensation through Encapsulation in Water.

Two organic cages have been prepared in situ in water through the 2 + 3 hydrazone coupling of two pyridinium-derived trialdehydes and oxalohydrazide. The highly water-soluble cages encapsulate and solubilize linear neutral molecules. Such encapsulation has been applied for the promotion of both two- or three-component hydrazone condensation in water.

Ectopic thyroid gland located on the L4 vertebral body: A case report.

Rationale: The prevalence of ectopic thyroid is extremely low, with the condition observed in approximately 1 in 100,000 to 300,000 people. Thyroid gland ectopia develops as a result of the presence of developmental abnormalities during the migration of the thyroid anlage from the floor of the primitive foregut to its final position in the neck. Ectopic thyroid tissue is commonly observed in the lingual region, but can also present in other head and neck regions, as well as regions located at a large distance from the neck.

Second-order nonlinear optical materials with a benzene-like conjugated π system.

Second-order nonlinear optical (NLO) materials that can alter the wavelength of lasers have attracted significant attention for their optoelectronic applications. Recent research suggests that benzene-like structure units, such as [BO] and [CNO] rings, are promising building units to construct new NLO materials with excellent optical properties. In this feature article, we will introduce the recent development of benzene-like ring based NLO materials with a highlight of our contributions, illustrating how to optimize the conjugated π system, including arrangement modes, different linkers, and isoelectronic species, to tune the band gap and NLO properties.

CsAlBOF: a beryllium-free deep-ultraviolet nonlinear optical material with enhanced thermal stability.

The design of new beryllium-free deep-ultraviolet nonlinear optical materials is important but challenging. Here, we describe a new strategy to search for such materials based on rational selection of fundamental structural units. By combining asymmetric AlOF tetrahedra and π-conjugated BO rings, a new aluminum borate fluoride, CsAlBOF was obtained.

Extensive disseminated cysticercosis: a case report in Yunnan province, China.

Background: Cysticercosis is spreading all over the world and it is a major health problem in most countries of Latin America, Africa, and Asia. Extensive disseminated cysticercosis is relatively rare and fewer than 120 case have been reported in the worldwide. We reported a rare case of extensive disseminated cysticercosis in Yunan province, China.