Mirvetuximab Soravtansine in solid tumors: A systematic review and meta-analysis.

Background: Mirvetuximab Soravtansine (MIRV) is a promising antibody‒drug conjugate (ADC) that targets folate receptor alpha (FRα), which is overexpressed in several types of solid tumors. In November 2022, MIRV was approved in the USA for the treatment of adult patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer who received 1-3 prior systemic treatment regimens. Therefore, high-quality evidence for its efficacy and safety in different cancers is urgently needed.

Boron modification of AuRh mesoporous nanotubes for electro-reduction of nitrogen to ammonia.

Electrocatalytic nitrogen reduction reaction (NRR) is a prospective tactics for ammonia synthesis. However, the development of highly active NRR electrocatalysts is still challenging owing to the difficult activation of nitrogen and competitive hydrogen evolution reaction (HER). Here, we synthesized boron-doped AuRh mesoporous nanotubes (B-AuRh MNTs) via dual-template method coupled with boron doping.

The impact of lymphadenectomy on the survival of patients with stage I ovarian clear cell carcinoma.

Objective: To assess the impact of lymphadenectomy on the survival of patients with stage I ovarian clear cell carcinoma (OCCC).

Methods: The records of 93 patients with stage I OCCC treated between January 2012 and December 2019 were reviewed retrospectively. The relationships between survival outcomes and the number and region of removed lymph nodes (LNs) were assessed, and the independent prognostic factors were analyzed.

Proton Ionic Liquid Modulates Hydrogen Coverage and Subsurface Absorbed Hydrogen to Enhance Pd Metallene Electrocatalytic Semi-hydrogenation of Alkynols.

Electrochemical semi-hydrogenation of alkynols to produce high-value alkenols is a green and sustainable approach. Although Pd can exhibit excellent semi-hydrogenation properties, its intrinsic mechanism still lacks in-depth study. Herein, a proton ionic liquid (PIL)-modified Pd metallene (Pdene@PIL) is synthesized for the electrocatalytic semi-hydrogenation of 2-methyl-3-butyn-2-ol (MBY) to 2-methyl-3-buten-2-ol (MBE).

Case report: Whole exome sequencing reveals a novel splicing variant of gene in a Chinese male juvenile with developmental delay and transient tic disorder.

Background: The Ankyrin Repeat Domain Containing Protein 17 (, OMIM:615929) gene is a protein-coding gene associated with diseases such as Chopra-Amiel-Gordon Syndrome and Non-Specific Syndromic Intellectual Disability. The protein encoded by gene belongs to the ankyrin repeat-containing protein family, which is one of the most widely existing protein domains that exclusively mediate protein-protein interactions. To date, the research and reports on the gene are limited.

Dual Hydrogen Production System: Synergistic Effect of Ru and Ce Over CuO Nanotubes Drives Hydrogen Evolution and Formaldehyde Oxidation.

Water splitting for hydrogen production is limited by high cell voltage and low energy conversion efficiencies due to the slow kinetic process of the oxygen evolution reaction (OER). Here, an electrolytic system is constructed in which the cathode and anode co-release H at ultra-low input voltage using formaldehyde oxidation reaction (FOR) instead of OER. The prepared RuCe co-doped CuO nanotubes on copper foam (RuCe-CuO/CF) are used as electrode materials for the HER-FOR system.

Energy-Saving Ambient Electrosynthesis of Nylon-6 Precursor Coupled with Electrocatalytic Upcycling of Polyethylene Terephthalate.

Cyclohexanone oxime is an important intermediate in the chemical industry, especially for the manufacture of nylon-6. The traditional cyclohexanone oxime production strongly relies on cyclohexanone-hydroxylamine and cyclohexanone ammoxidation processes, which require harsh reaction conditions and consume considerable amounts of energy. Herein, direct electrosynthesis of cyclohexanone oxime is reported from environmental pollutants nitrite and cyclohexanone with almost 100% yield by using low-cost CuSe nanosheets as electrocatalysts.

Case report: Genetic diagnoses in a pediatric patient with retinoblastoma and comorbid global developmental delay: three distinct entities diagnosed by whole exome sequencing in a single patient.

Background: The objective of this study was to explore the genetic etiology and propose a genetic diagnosis and counseling strategy for children with retinoblastoma (RB) and global developmental delay (GDD).

Case Presentation: We report on a 2 years and 4 months old boy with binocular retinoblastoma and global developmental delay (included intellectual disability, language development delay, motor development delay, etc.).

Prognostic value of human papillomavirus cell-free DNA in cervical cancer patients: A systematic review and meta-analysis.

Objective: This meta-analysis aimed to investigate the association between circulating human papillomavirus (HPV) cell-free DNA and oncological outcomes of cervical cancer patients.

Methods: Searches were performed in MEDLINE, Embase, and CENTRAL from their inception until 26 November 2023. Inclusion criteria were: (1) pathologically confirmed cervical cancer with available HPV test results; (2) detection of HPV cell-free DNA was performed in serum/plasma before or at end of treatment; (3) studies reported oncological outcomes of cervical cancer patients according to the levels of HPV cell-free DNA.

Electrocatalytic Valorization of Nitrate and Polyester Plastic for Simultaneous Production of Ammonia and Glycolic Acid.

Electrochemical upcycling of nitrate and polyester plastic into valuable products is an ideal solution to realize the resource utilization. Here, the co-production of ammonia (NH) and glycolic acid (GA) via electrochemical upcycling of nitrate and polyethylene terephthalate (PET) plastics over mesoporous PdAu film on Ni foam (mPdAu/NF), which is synthesized by micelle-assisted replacement method, is proposed. The mPdAu/NF with well-developed mesoporous structure provides abundant active sites and facilitated transfer channels and strong electronic effect.

Modulating Hydrogen Adsorption by Unconventional p-d Orbital Hybridization over Porous High-Entropy Alloy Metallene for Efficient Electrosynthesis of Nylon-6 Precursor.

Renewable electricity driven electrosynthesis of cyclohexanone oxime (CHNO) from cyclohexanone (CHO) and nitrogen oxide (NO) is a promising alternative to traditional environment-unfriendly industrial technologies for green synthesis of CHNO. Precisely controlling the reaction pathway of the CHO/NO-involved electrochemical reductive coupling reaction is crucial for selectively producing CHNO, which is yet still challenging. Herein, we report a porous high-entropy alloy PdCuAgBiIn metallene (HEA-PdCuAgBiInene) to boost the electrosynthesis of CHNO from CHO and nitrite, achieving a high Faradaic efficiency (47.

Heterointerface-Rich NiN/WO Hierarchical Nanoarrays for Efficient Glycerol Oxidation-Assisted Alkaline Hydrogen Evolution.

Glycerol oxidation-assisted water electrolysis has emerged as a cost-effective way of co-producing green hydrogen and HCOOH. Still, preparing highly selective and stable nickel-based metal electrocatalysts remains a challenge. Herein, heterostructure NiN/WO nanosheet arrays of bifunctional catalysts with large specific surface areas loaded on nickel foam (denoted as NiN/WO/NF) were synthesized.

Amorphous/crystalline RhFeP metallene for hydrazine-assisted water splitting.

Replacing the slow oxygen evolution reaction with favorable hydrazine oxidation reaction (HzOR) is a green and efficient way to produce hydrogen. In this work, we synthesize amorphous/crystalline RhFeP metallene via phase engineering and heteroatom doping. RhFeP metallene has good catalytic activity and stability for HER and HzOR, and only an ultralow voltage of 18 mV is required to achieve 10 mA cmin a two-electrode hydrazine-assisted water splitting system.

Case Report: A Rare Case of Primary Angiosarcoma of the Cervix with a Literature Review.

Primary angiosarcomas are a rare type of soft-tissue sarcomas that originate from endothelial cells. These sarcomas can develop in any part of the body and have a poor prognosis. However, they are commonly found in the skin of elderly white men, particularly on the scalp and head region.

Synthesis of hierarchical mordenite by solvent-free method for dimethyl ether carbonylation reaction.

A series of hierarchical mordenite (MOR) catalysts were synthesized by adding soft templates the solvent-free method. The influence of different kinds of soft templates on the structure, morphology and acid sites of mordenite were systematically characterized. The characterization results revealed that the addition of soft templates could successfully introduce hierarchical structure into the system while maintaining good crystallinity.

A loss-of-function variant in ZCWPW1 causes human male infertility with sperm head defect and high DNA fragmentation.

Background: Male infertility is a global health issue. The more causative genes related to human male infertility should be further explored. The essential role of Zcwpw1 in male mouse fertility has been established and the role of ZCWPW1 in human reproduction needs further investigation to verify.

Interstitial Boron-Modulated Porous Pd Nanotubes for Ammonia Electrosynthesis.

Electrochemical conversion of nitrogen into ammonia at ambient conditions as a sustainable approach has gained significant attention, but it is still extremely challenging to simultaneously obtain a high faradaic efficiency (FE) and NH yield. In this work, the interstitial boron-doped porous Pd nanotubes (B-Pd PNTs) are constructed by combining the self-template reduction method with boron doping. Benefiting from distinctive one-dimensional porous nanotube architectonics and the incorporation of the interstitial B atoms, the resulting B-Pd PNTs exhibit high NH yield (18.

Overall Spontaneous Water Splitting for Calcium Bismuthate Ca(BiO): Flexible-Electronic-Controlled Band Edge Position and Adsorption-Site-Modulated Bond Strength.

Eco-friendly photocatalysts for water splitting, highly efficient in oxygen/hydrogen evolution reactions, hold great promise for the storage of inexhaustible solar energy and address environmental challenges. However, current common photocatalysts rarely exhibit both H and O production performances unless some regulatory measures, such as strain engineering, are implemented. Additionally, the extensive utilization of flexible electronics remains constrained by their high Young's modulus.

Boron-intercalation-triggered crystalline transition of Pd nanosheet assemblies for an enhanced oxygen reduction reaction.

The development of effective and stable cathode electrocatalysts is highly desired for fuel cells. Controlling the composition and morphology of Pd-based materials can provide a great opportunity to improve their oxygen reduction reaction (ORR) performance. Here, we report the synthesis of hexagonal close-packed (hcp) PdB nanosheet assemblies (PdB NAs) via the boronation reaction between as-synthesized Pd NAs and N,N-dimethylformamide.

Electronic structure engineering on Co-based metal-organic frameworks for concurrent electrocatalytic hydrogen generation and formate electrosynthesis.

A facile one-step solvothermal method was developed to synthesize Ir-doped Co-based metal-organic framework (CoIr-MOF) nanoarrays as a bifunctional electrocatalyst for water-glucose co-electrolysis. It was demonstrated that incorporation of a low-content of Ir cations could modulate the electronic structure of Co active centers and thus boost the electrocatalytic performance towards both the hydrogen evolution reaction and glucose-to-formate oxidation reaction.