Genetic analyses identify circulating genes related to brain structures associated with Parkinson's disease.

Magnetic resonance imaging and circulating molecular testing are potential methods for diagnosing and treating Parkinson's disease (PD). However, their relationships remain insufficiently studied. Using genome-wide association summary statistics, we found in the general population a genetic negative correlation between white matter tract mean diffusivity and PD (-0.

Retraction notice to "A deep learning approach based on graphs to detect plantation lines" [Heliyon Volume 10, Issue 11, 15 June 2024, e31730].

[This corrects the article DOI: 10.1016/j.heliyon.

TOB1 inhibits the gastric cancer progression by focal adhesion pathway and ERK pathway based on transcriptional and metabolic sequencing.

Gastric cancer is one of the most malignant digestive tract tumors worldwide and its progression is associated with gene expression and metabolic alteration. We revealed that the gastric cancer patients with lower expression level of TOB1 exhibited poorer overall survivals according to the data in Kaplan-Meier Plotter. The unphosphorylated TOB1 protein which is effective expressed lower in gastric cancer cells.

Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19 cognitive dysfunction through systems genetics approach.

The dysregulation of Angiotensin-converting enzyme 2 (ACE2) in central nervous system is believed associates with COVID-19 induced cognitive dysfunction. However, the detailed mechanism remains largely unknown. In this study, we performed a comprehensive system genetics analysis on hippocampal ACE2 based on BXD mice panel.

Progression of mA in the tumor microenvironment: hypoxia, immune and metabolic reprogramming.

Recently, N6-methyladenosine (mA) has aroused widespread discussion in the scientific community as a mode of RNA modification. mA comprises writers, erasers, and readers, which regulates RNA production, nuclear export, and translation and is very important for human health. A large number of studies have found that the regulation of mA is closely related to the occurrence and invasion of tumors, while the homeostasis and function of the tumor microenvironment (TME) determine the occurrence and development of tumors to some extent.

ADM-SLAM: Accurate and Fast Dynamic Visual SLAM with Adaptive Feature Point Extraction, Deeplabv3pro, and Multi-View Geometry.

Visual Simultaneous Localization and Mapping (V-SLAM) plays a crucial role in the development of intelligent robotics and autonomous navigation systems. However, it still faces significant challenges in handling highly dynamic environments. The prevalent method currently used for dynamic object recognition in the environment is deep learning.

A deep learning approach based on graphs to detect plantation lines.

Identifying plantation lines in aerial images of agricultural landscapes is re-quired for many automatic farming processes. Deep learning-based networks are among the most prominent methods to learn such patterns and extract this type of information from diverse imagery conditions. However, even state-of-the-art methods may stumble in complex plantation patterns.

Systems Genetics Analyses Reveals Key Genes Related to Behavioral Traits in the Striatum of CFW Mice.

The striatum plays a central role in directing many complex behaviors ranging from motor control to action choice and reward learning. In our study, we used 55 male CFW mice with rapid decay linkage disequilibrium to systematically mine the striatum-related behavioral functional genes by analyzing their striatal transcriptomes and 79 measured behavioral phenotypic data. By constructing a gene coexpression network, we clustered the genes into 13 modules, with most of them being positively correlated with motor traits.

Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function.

Background: There is growing evidence of a strong correlation between pain sensitivity and cognitive function under both physiological and pathological conditions. However, the detailed mechanisms remain largely unknown. In the current study, we sought to explore candidate genes and common molecular mechanisms underlying pain sensitivity and cognitive function with a transcriptome-wide association study using recombinant inbred mice from the BXD family.

Expression patterns of cluster of differentiation 147 impact the prognosis of hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) has very low overall survival. According to global cancer statistics, approximately 905677 new cases were reported in 2020, with at least 830180 of them being fatal. Cluster of differentiation 147 (CD147) is a novel, transmembrane glycoprotein that is expressed in a wide variety of tumor cells and plays an important role in various stages of tumor development.

BECS-II: an updated bio-inspired electrocommunication system for small underwater robots.

Some weakly electric fish can use electric signals to interact and communicate with each other in dark and complex underwater environments where traditional underwater communication fails. In our previous work, we developed a bio-inspired electrocommunication system (BECS) that serves as an effective alternative to traditional methods in this challenging underwater scenario performing communication at a speed of approximately 1200 bps (bits per second) within approximately 3 m. In this study, a novel underwater wireless communication system (BECS-II) is proposed to upgrade the BECS with much better performance.

Contribution of PGAP3 co-amplified and co-overexpressed with ERBB2 at 17q12 involved poor prognosis in gastric cancer.

The locus at 17q12 erb-b2 receptor tyrosine kinase 2 (ERBB2) has been heavily amplificated and overexpressed in gastric cancer (GC), but it remains to be elucidated about the clinical significance of the co-amplification and co-overexpression of PGAP3 gene located around ERBB2 in GC. The profile of PGAP3 and ERBB2 in four GC cell lines and tissue microarrays containing 418 primary GC tissues was assessed to investigate the co-overexpression and clinical significance of the co-amplified genes, and to evaluate the impact of the co-amplified genes on the malignancy of GC. Co-amplification of PGAP3 and ERBB2 accompanied with co-overexpression was observed in a haploid chromosome 17 of NCI-N87 cells with double minutes (DMs).

Nanosheets of two-dimensional photoluminescent lanthanide phosphonocarboxylate frameworks decorated with free carboxylic groups for latent fingerprint imaging.

The synthesis, structural characterization, exfoliation, and photophysical studies of two-dimensional (2-D) lanthanide phosphonates, named Ln(m-pbc); [Ln(-Hpbc)(-Hpbc)(HO)] (Ln = Eu, Tb; -pbc = 3-phosphonobenzoic acid) based on the phosphonocarboxylate ligand, are reported. These compounds are neutral polymeric 2D layered structures with pendent uncoordinated carboxylic groups between layers. The nanosheets were obtained by a top-down strategy involving sonication-assisted solution exfoliation and characterized by atomic force microscopy and transmission electron microscropy, showing lateral dimensions from nano- to micro-meter scales, and thicknesses down to several layers.

Fast reconstruction of multiphase microstructures based on statistical descriptors.

In this paper, we propose a hierarchical simulated annealing of erosion method (HSAE) to improve the computational efficiency of multiphase microstructure reconstruction, whose computational efficiency can be improved by an order of magnitude. Reconstruction of the two-dimensional (2D) and three-dimensional (3D) multiphase microstructures (pore, grain, and clay) based on simulated annealing (SA) and HSAE are performed. In the reconstruction of multiphase microstructure with HSAE and SA, three independent two-point correlation functions are chosen as the morphological information descriptors.

Association between P-Selectin Autoantibody Positive and Response to Steroid Treatment in Newly Diagnosed Immune Thrombocytopenia Patients.

Objective: This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients.

Methods: The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment from October 2016 to May 2021 were retrospectively analyzed. Treatment responses were evaluated within 3 months after the onset of treatment.

Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1α-Dependent Glucose Metabolism in Gastric Carcinoma.

Background: Hypoxia-induced chemoresistance is recognized as a major obstacle to the successful treatment of gastric cancer (GC). Circular RNAs (circRNAs) have been proposed to implicate in resistance to chemotherapeutic drugs. However, whether circNRIP1 is involved in the development of hypoxia-induced 5-fluorouracil (5-FU) resistance remains largely unknown.

Efficient hybrid method for electromagnetic scattering from a coated object above a two-layered rough surface.

A powerful and efficient hybrid method combining the finite-element boundary-integral method with fast multipole method (FE-BI-FMM) is proposed in this paper to study the electromagnetic scattering characteristics from a coated object above a two-layered dielectric rough surface. The finite-element method (FEM) is applied to model the scattering from the coated object, and multiple interactions between the object and layered rough surface are handled by the FMM-enhanced boundary integral method (BIM). A hybrid solver is adopted to efficiently solve the FEM-BIM matrix equation.

Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer.

TOB1, a member of the BTG/TOB protein family, inhibits tumor cell proliferation. We previously observed down-regulation and phosphorylation of TOB1 in gastric cancer (GC). Here, we examined the subcellular distribution and clinical significance of TOB1 expression and phosphorylation in GC.

Adaptive single-pixel imaging based on guided coefficients.

The existing adaptive single-pixel imaging methods suffer from a waste of sampling resources. The sampling resources are not used adequately for superior localization of significant coefficients and reconstruction. In this paper, an adaptive single-pixel imaging method via the guided coefficients in the Haar wavelet tree is proposed.

Three Zinc(II) Phosphonates: Syntheses, Structures and Sensing of Copper(II) Ions.

Three zinc(II) phosphonocarboxylates, [Zn (m-bpc) (OH)]⋅(CH ) NH ⋅H O (1), [Zn (m-bpc)(m-Hbpc)(4,4'-bpy)]⋅(CH ) NH ⋅H O (2) and [Zn (m-bpc) (4,4'-bpy)(CH ) NH]⋅H O (3) (m-H bpc=3-phosphonobenzoic acid, 4,4'-bpy=4,4'-bipyridine), have been solvothermally synthesised to generate unique topologies, as characterised by single-crystal XRD. Compound 1 possesses a diamond topology, which has rarely been found among phosphonate-based metal-organic frameworks. Compound 2 shows a 2D layered structure with pendant m-Hbpc and 4, 4'-bpy ligands, in which the layers feature as a zeolite-like network.

Compressive adaptive ghost imaging via sharing mechanism and fellow relationship.

For lower sampling rate and better imaging quality, a compressive adaptive ghost imaging is proposed by adopting the sharing mechanism and fellow relationship in the wavelet tree. The sharing mechanisms, including intrascale and interscale sharing mechanisms, and fellow relationship are excavated from the wavelet tree and utilized for sampling. The shared coefficients, which are part of the approximation subband, are localized according to the parent coefficients and sampled based on the interscale sharing mechanism and fellow relationship.

Single Image Superresolution via Directional Group Sparsity and Directional Features.

Single image superresolution (SR) aims to construct a high-resolution version from a single low-resolution (LR) image. The SR reconstruction is challenging because of the missing details in the given LR image. Thus, it is critical to explore and exploit effective prior knowledge for boosting the reconstruction performance.

Color-direction patch-sparsity-based image inpainting using multidirection features.

This paper proposes a color-direction patch sparsity-based image in painting method to better maintain structure coherence, texture clarity, and neighborhood consistence of the in painted region of an image. The method uses super-wavelet transform to estimate the multi-direction features of a degraded image, and combines with color information to construct the weighted color-direction distance (WCDD) to measure the difference between two patches. Based on the WCDD, the color-direction structure sparsity is defined to obtain a more robust filling order and more suitable multiple candidate patches are searched.