Comparing the outcomes of MR-based versus CT-based tumor delineation in locally advanced non-small cell lung cancer treated with hypo-fractionated radiotherapy and concurrent chemotherapy.

Background: Delineating gross tumor volume (GTV) using computed tomography (CT) imaging is the standard for lung cancer contouring, but discrepancies among observers compromise accuracy and reliability. Magnetic resonance imaging (MRI) provides superior soft-tissue resolution compared to CT, thus, we design this retrospective study to compare the treatment outcomes of magnetic resonance-based (MR-based) and CT-based tumor delineation in locally advanced non-small cell lung cancer (LA-NSCLC) patients treated with hypo-fractionated concurrent chemoradiotherapy (hypo-CCRT).

Methods: A total of 293 LA-NSCLC patients treated with hypo-CCRT from three trials between October 2015 and October 2020 were screened.

Dosimetric evaluation of different planning strategies for hypofractionated whole-breast irradiation technique.

The dose hotspot areas in hypofractionated whole-breast irradiation (WBI) greatly increase the risk of acute skin toxicity because of the anatomical peculiarities of the breast. In this study, we presented several novel planning strategies that integrate multiple sub-planning target volumes (sub-PTVs), field secondary placement, and RapidPlan models for right-sided hypofractionated WBI.A total of 35 cases of WBI with a dose of 42.

Plan quality and treatment efficiency assurance of two VMAT optimization for cervical cancer radiotherapy.

Unlabelled: To investigate the difference of the fluence map optimization (FMO) and Stochastic platform optimization (SPO) algorithm in a newly-introduced treatment planning system (TPS).

Methods: 34 cervical cancer patients with definitive radiation were retrospectively analyzed. Each patient has four plans: FMO with fixed jaw plans (FMO-FJ) and no fixed jaw plans (FMO-NFJ); SPO with fixed jaw plans (SPO-FJ) and no fixed jaw plans (SPO-NFJ).

An exploratory analysis of MR-guided fractionated stereotactic radiotherapy in patients with brain metastases.

Purpose: To assess the feasibility and potential benefits of online adaptive MR-guided fractionated stereotatic radiotherapy (FSRT) in patients with brain metastases (BMs).

Methods And Materials: Twenty-eight consecutive patients with BMs were treated with FSRT of 30 Gy in 5 fractions on the 1.5 T MR-Linac.

Development of a GPU-superposition Monte Carlo code for fast dose calculation in magnetic fields.

To develop and validate a graphics processing unit (GPU) based superposition Monte Carlo (SMC) code for efficient and accurate dose calculation in magnetic fields.A series of mono-energy photons ranging from 25 keV to 7.7 MeV were simulated with EGSnrc in a water phantom to generate particle tracks database.

Dosimetric Accuracy of MR-Guided Online Adaptive Planning for Nasopharyngeal Carcinoma Radiotherapy on 1.5 T MR-Linac.

Purpose: The aim of this study is to evaluate the dose accuracy of bulk relative electron density (rED) approach for application in 1.5 T MR-Linac and assess the reliability of this approach in the case of online adaptive MR-guided radiotherapy for nasopharyngeal carcinoma (NPC) patients.

Methods: Ten NPC patients formerly treated on conventional linac were included in this study, with their original planning CT and MRI collected.

Achyrophenols A-F: Polycyclic Polyphenol Lactone Skeletons and a Nor-Ursane-Type Triterpenoid from .

Two novel derivatives of 2-methyl-1-(2,3,4,6-tetrahydroxyphenyl)propan-1-one and ()-2-methyl-1-(2,3,4,6-tetrahydroxyphenyl)butan-1-one ( and ), four novel six-membered lactone phenols (-), and a nor-ursane type triterpenoid () named Achroacid, were isolated from the aerial part of . The absolute configurations of - are presented by spectroscopic data and X-ray crystallographic analysis. A DP4plus evaluation was applied to determine the final stereochemistry for and .

Extension and validation of a GPU-Monte Carlo dose engine gDPM for 1.5 T MR-LINAC online independent dose verification.

Purpose: To extend and validate the accuracy and efficiency of a graphics processing unit (GPU)-Monte Carlo dose engine for Elekta Unity 1.5 T Magnetic Resonance-Linear Accelerator (MR-LINAC) online independent dose verification.

Methods: Electron/positron propagation physics in a uniform magnetic field was implemented in a previously developed GPU-Monte Carlo dose engine-gDPM.

Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.

In this work, a novel strategy was developed for separation and enrichment of sibiskoside by dummy molecular imprinting technology and magnetic separation technology. The structural analogue geniposide was selected as the dummy template, using 4-vinylpyridine as the functional monomer, ethylene glycol dimethacrylate as the cross-linking agent, and acetonitrile as the porogen. The molecularly imprinted layer was formed on the surface of the magnetic carrier to prepare dummy template molecularly imprinted polymers (DMIPs) with a core-shell structure.

Correlation of autophagy-related genes for predicting clinical prognosis in colorectal cancer.

Autophagy plays a controversial role in cancer. The role of autophagy-related genes (ARGs) in colorectal cancer (CRC) was evaluated based on publicly available data from The Cancer Genome Atlas and the Human Autophagy Database. After collecting CRC-related transcript and clinical data and a list of ARGs from public databases, the Wilcoxon test was used to identify the differentially expressed ARGs between CRC and paired normal tissues.

Comparison of Intensity Modulated Radiotherapy Treatment Plans Between 1.5T MR-Linac and Conventional Linac.

In this study, we assess the dosimetric qualities and usability of planning for 1.5 T MR-Linac based intensity modulated radiotherapy (MRL-IMRT) for various clinical sites in comparison with IMRT plans using a conventional linac. In total of 30 patients with disease sites in the brain, esophagus, lung, rectum and vertebra were re-planned retrospectively for simulated MRL-IMRT using the Elekta Unity dedicated treatment planning system (TPS) Monaco (v5.

In-Air Electron Streaming Effect for Esophageal Cancer Radiotherapy With a 1.5 T Perpendicular Magnetic Field: A Treatment Planning Study.

Purpose: To investigate the in-air out-of-field electron streaming effect (ESE) for esophageal cancer radiotherapy in the presence of 1.5 T perpendicular magnetic field.

Methods: Ten esophageal cancer patients treated with conventional Linac were retrospectively enrolled into a cohort of this study, with the prescription of 4,400 cGy/20 fx.

Feasibility of using a commercial collapsed cone dose engine for 1.5T MR-LINAC online independent dose verification.

Purpose: To validate the feasibility and accuracy of commonly used collapsed cone (CC) dose engine for Elekta Unity 1.5T MR-LINAC online independent dose verification.

Materials And Methods: The Unity beam model was built and commissioned in RayStation treatment planning system with CC dose engine.

Hierarchical Porous MoS/C Nanospheres Self-Assembled by Nanosheets with High Electrochemical Energy Storage Performance.

To overcome the deficiency of the volume expansion of MoS as the anode material for lithium-ion batteries (LIBs), an effective strategy was developed to design hierarchical porous MoS/carbon nanospheres via a facile, easy-operated hydrothermal method followed by annealing. FESEM and TEM images clearly showed that nanospheres are composed of ultra-thin MoS/C nanosheets coated with carbon layer and possess an expanded interlayer spacing of 0.98 nm.

Hypolipidemic constituents from the aerial portion of Sibiraea angustata.

Two new monoterpene acylglucosides (1-2) and one new aromatic glycoside (3), together with five known compounds (4-8), were isolated from 95% ethanol extract of Sibiraea angustata. The structures of these compounds were characterized by 2D-NMR and mass spectrometry. Compounds were evaluated for their hypolipidemic activity using oleic acid-induced lipid accumulation in HepG2 cells.

A fast robust optimizer for intensity modulated proton therapy using GPU.

Robust optimization has been shown to be effective for stabilizing treatment planning in intensity modulated proton therapy (IMPT), but existing algorithms for the optimization process is time-consuming. This paper describes a fast robust optimization tool that takes advantage of the GPU parallel computing technologies. The new robust optimization model is based on nine boundary dose distributions - two for ±range uncertainties, six for ±set-up uncertainties along anteroposterior (A-P), lateral (R-L) and superior-inferior (S-I) directions, and one for nominal situation.

ZIF-67-Derived CoSe/NC Composites as Anode Materials for Lithium-Ion Batteries.

As a typical metal selenide, CoSe is a kind of foreground anode material for lithium-ion batteries (LIBs) because of its two-dimensional layer structure, good electrical conductivity, and high theoretical capacity. In this work, the original CoSe/N-doped carbon (CoSe/NC) composites were synthesized using ZIF-67 as a precursor, in which the CoSe nanoparticles are encapsulated in NC nanolayers and they are connected through C-Se bonds. The coating structure and strong chemical coupling make the NC nanolayers could better effectively enhance the lithium storage properties of CoSe/NC composites.

Six new anthraquinone glycosides from Merr.

Six new anthraquinones named lasianthuoside F (1), G (2), H (3), I (4), J (5), K (6) were isolated from an acetone extract of the root of . Their structures were elucidated by physical and chemical evidence and spectral analysis.

A flexible, room-temperature and solution-processible copper nanowire based transparent electrode protected by reduced graphene oxide exhibiting high performance and improved stability.

Advances in flexible electronic and optoelectronic devices have caused higher requirements for fabricating high-performance and low cost flexible transparent conductive electrodes (TCEs). Copper nanowires (Cu NWs) possess excellent electrical and optical properties, but the large contact resistance and poor stability limit their practical application in optoelectronic devices. In this work, we report a robust, convenient and environment-friendly method to assemble copper nanowires/reduced graphene oxide (Cu NWs/rGO) TCEs with enhanced conductivity, flexibility and stability at room temperature.

MOF-Derived ZnSe/N-Doped Carbon Composites for Lithium-Ion Batteries with Enhanced Capacity and Cycling Life.

In this work, three different morphologies of ZnSe/N-doped carbon (NC) composites are synthesized using ZIF-8 by a facile calcination process. By adjusting the particle size of precursor ZIF-8, the morphology and size of the product ZnSe/NC can be controlled. The as-prepared ZnSe/NC composites show excellent cyclic stability and rate capability as anode materials in lithium-ion batteries (LIBs).

TOPAS Monte Carlo simulation for double scattering proton therapy and dosimetric evaluation.

Purpose: To construct and commission a double scattering (DS) proton beam model in TOPAS Monte Carlo (MC) code. Dose comparisons of MC calculations to the measured and treatment planning system (TPS) calculated dose were performed.

Methods: The TOPAS nozzle model was based on the manufacturer blueprints.

Amido surface-functionalized magnetic molecularly imprinted polymers for the efficient extraction of Sibiskoside from Sibiraea angustata.

A general method for efficient and selective extraction of a target compound from complex natural products remains elusive, despite decades of research. By introducing a functional amido group on the surface of dispersity-enhanced magnetic nanoparticles, a nanoparticle receptor to selectively recognize Sibiskoside (a monoterpene) from the aerial portion of Sibiraea angustata by hydrogen bond interaction was synthesized. The superparamagnetic FeO nanoparticles were successively modified with tetraethyl orthosilicate (TEOS), amino and amido functional groups, and 4-vinylbenzoic acid (VBZA) was used as the functional monomer.

Rechargeable K-Se batteries based on metal-organic-frameworks-derived porous carbon matrix confined selenium as cathode materials.

In this work, porous carbon matrix derived from metal-organic frameworks is synthesized by a facile carbonation process for confining element selenium. The Se/nitrogen-doped porous carbon composite is applied as the cathode for rechargeable K-Se batteries for the first time. The abundant and hierarchical porous structure is advantageous in overcoming the volume expansion problem caused by polyselenides during discharge-charge process.

Fabrication of high-quality copper nanowires flexible transparent conductive electrodes with enhanced mechanical and chemical stability.

Copper nanowires (Cu NWs) become a potential functional material in future optoelectronic devices owing to their high optical transmittance, super electrical conductivity, and good flexibility as well as low cost. However, the drawbacks of Cu NWs with large contact resistance and poor stability make them far from the practical implementations. Herein we report a robust method to fabricate high-quality Cu NWs transparent conductive electrodes (TCEs) with enhanced mechanical and chemical stability at room temperature.