Overburden movement law in strip filling mining of upward mining faces.

Strip filling mining significantly improves coal recovery rates and fosters sustainable development in the coal industry. To investigate the overburden movement patterns of strip filling mining, a mine in Tuokexun was selected as the study site. The stability of the composite structure in upward mining faces, as well as the stress distribution and fracture characteristics of the overburden at different stages of strip filling mining, were analyzed using theoretical methods, numerical simulations, and similarity experiments.

Niraparib Enhances and Synergizes with Ganglioside GD2 to Potentiate its Inhibitory Effect on Bladder Cancer Cells.

Purpose: This study aimed to study the inhibitory effect of niraparib alone or in combination with GD2 specific antibody on Bladder Cancer (BCa).

Methods: The migration ability of BCa cells was assessed through a scratch assay. CCK-8 assay was performed to evaluate the viability of BCa cells, and Transwell invasion assays were utilized to examine invasive capacity.

PCB plug-in solder joint defect detection method based on coordinated attention-guided information fusion.

Printed Circuit Boards (PCBs) are the foundational component of electronic devices, and the detection of PCB defects is essential for ensuring the quality control of electronic products. Aiming at the problem that the existing PCB plug-in solder defect detection algorithms cannot meet the requirements of high precision, low false alarm rate, and high speed at the same time, this paper proposes a method based on spatial convolution pooling and information fusion. Firstly, on the basis of YOLOv3, an attention-guided pyramid structure is used to fuse context information, and multiple convolutions of different size are used to explore richer high-level semantic information; Secondly, a coordinated attention network structure is introduced to calibrate the fused pyramidal feature information, highlighting the important feature channels, and reducing the adverse impact of redundant parameters generated by feature fusion; Finally, the ASPP (Atrous Spatial Pyramid Pooling) structure is implemented in the original Darknet53 backbone feature extraction network to acquire multi-scale feature information of the detection targets.

A novel compound heterozygous PCDH15 variants is associated with arRP in a Chinese pedigree.

Background: Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal diseases. However, it is still not well understand about the relationship between PCDH15 variants and RP.

Methods: In this study, we enrolled a Chinese autosomal recessive retinitis pigmentosa (arRP) pedigree and identified the causative gene in the proband by targeted whole exome sequencing (WES).

Semi-Kinematic Coupling Design and Analysis for Giant Steerable Science Mirror Prototype of Thirty Meter Telescope.

The Giant Steerable Science Mirror prototype is being developed to assess the tertiary mirror system of the Thirty Meter Telescope. In this study, a new semi-kinematic coupling design is proposed for the prototype based on three pairs of V-grooves and canoe-like components to allow for high repeatability accuracy under heavy loads. A mathematical model was constructed to estimate the repeatability accuracy using the corresponding measurement results and machining errors.

Effect of acupuncture on quality of life in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial.

Objectives: To observe the effect and safety of acupuncture on quality of life, pain, and prostate symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Methods: Seventy patients with CP/CPPS were randomly divided into an acupuncture group (35 cases, 1 case was eliminated) and a sham acupuncture group (35 cases, 3 cases dropped out). The patients in the acupuncture group were treated with routine acupuncture at bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6), while the patients in the sham acupuncture group were treated with shallow needling at non-meridian and non-acupoint points beside bilateral Zhongliao (BL 33), Huiyang (BL 35), Shenshu (BL 23) and Sanyinjiao (SP 6),without manipulation to induce arrival of ().

Oxygen Vacancy-Rich Bimetallic Au@Pt Core-Shell Nanosphere-Functionalized Electrospun ZnFeO Nanofibers for Chemiresistive Breath Acetone Detection.

Sensitive and selective acetone detection is of great significance in the fields of environmental protection, industrial production, and individual health monitoring from exhaled breath. To achieve this goal, bimetallic Au@Pt core-shell nanospheres (BNSs) functionalized-electrospun ZnFeO nanofibers (ZFO NFs) are prepared in this work. Compared to pure NFs-650 analogue, the ZFO NFs/BNSs-2 sensor exhibits a stronger mean response (3.

Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.

The prevalence of renal ischemia/reperfusion injury (IRI) in premenopausal women is considerably lower than that in age-matched men. This suggests that sex-related differences in mitochondrial function and homeostasis may contribute to sexual dimorphism in renal injury, though the mechanism remains unclear. Mouse model of unilateral left renal IRI with contralateral kidney enucleation, Ovariectomy in female mice, and a human embryonic kidney (HEK) cell model of hypoxia-reoxygenation were used to study how estrogen affects the sexual dimorphism of renal IRI through SIRT3 in vitro and in vivo, respectively.

Analysis of alignment requirements for off-axis resonant cavity based on coupling efficiency.

The optical path length stability of the off-axis four-reflection telescope is one of the key technical indicators for the TianQin gravitational wave detection system. In the MHz observation band, the telescope must exhibit an optical path length stability of 0.4 / .

Acute renal failure after kidney transplantation due to mizoribine-induced ureteral stones.

Introduction: Mizoribine (MZR) is used to prevent rejection reactions after kidney transplantation and increase the risk of hyperuricemia. There is a lack of reports of MZR-induced ureteral stones after kidney transplantation. The surgery treatment of ureteral stones in transplanted kidney is a challenging clinical issue that should only be performed by experienced urologists at professional centers.

Rapid calculation method for backscattered light of a space gravitational-wave detection telescope.

Stray light is a key issue that must be considered in the TianQin telescope. To solve the problem of a long simulation time and the inability of the simulation results to be fed back to guide the optical design, we propose a fast estimation method for stray light based on the FOV with high accuracy. Compared to other models, the error between our model and the software simulation results is smaller, within one order of magnitude.

Alkalized Cellulose Nanofiber-Interweaved PEDOT:PSS Thin-Film Sensors via Layer-by-Layer Spraying Assembly for Ultrafast Molecular Ammonia Detection.

As a typical representative of conductive polymers (CPs), poly(3,4-ethylenedioxythiophene): polystyrenesulfonate (PEDOT:PSS) is intensively employed for chemiresistive ammonia (NH) sensing on account of its favorable aqueous solubility, benign environmental stability, and outstanding room-temperature conductivity; however, it is severely plagued by low sensitivity and sluggish reaction kinetics. To circumvent these limitations, the guest-alkalized cellulose nanofibers (AC) were introduced into the host PEDOT:PSS matrix by the layer-by-layer spraying assembly method (LBLSA) in this work. The componential proportion-optimized PEDOT:PSS/AC/PEDOT:PSS (P/AC/P) sensor delivered a large sensitivity of 20.

Visual impairment and blindness caused by retinal diseases: A nationwide register-based study.

Background: Retinal disorders cause substantial visual burden globally. Accurate estimates of the vision loss due to retinal diseases are pivotal to inform optimal eye health care planning and allocation of medical resources. The purpose of this study is to describe the proportion of visual impairment and blindness caused by major retinal diseases in China.

Chloroform-infiltrated photonic crystal fiber with high-temperature sensitivity.

The temperature sensor is the core part of the temperature measurement instrument, and its performance directly determines the temperature measurement accuracy. Photonic crystal fiber (PCF) is a new type of temperature sensor with extremely high potential. In this paper, we propose a high-performance, structurally simple, liquid-filled PCF temperature sensor, which is based on a SMF-PCF-SMF (single mode fiber, SMF) sandwich structure.

Accelerating the Gas-Solid Interactions for Conductometric Gas Sensors: Impacting Factors and Improvement Strategies.

Metal oxide-based conductometric gas sensors (CGS) have showcased a vast application potential in the fields of environmental protection and medical diagnosis due to their unique advantages of high cost-effectiveness, expedient miniaturization, and noninvasive and convenient operation. Of multiple parameters to assess the sensor performance, the reaction speeds, including response and recovery times during the gas-solid interactions, are directly correlated to a timely recognition of the target molecule prior to scheduling the relevant processing solutions and an instant restoration aimed for subsequent repeated exposure tests. In this review, we first take metal oxide semiconductors (MOSs) as the case study and conclude the impact of the semiconducting type as well as the grain size and morphology of MOSs on the reaction speeds of related gas sensors.

Two-dimensional black phosphorus/tin oxide heterojunctions for high-performance chemiresistive HS sensing.

Hydrogen sulfide (HS) emission from industrial fields and bacteria decomposing of sulfur-containing organic matter poses a significant impact on human health and atmospheric environment, thus necessitating the development of a HS sensor with high sensitivity and exclusive selectivity especially at a very low dose. Chemiresistive sensors based on traditional metal oxides were readily limited by the elevated operating temperature and severe cross-sensitivity. To overcome these obstacles, we prepared two dimensional (2D) tin oxide (SnO) nanosheets decorated with thin black phosphorus (BP) as the sensing layer of MEMS HS sensors.

Modeling the resumption of work and production of enterprises during COVID-19: An SIR-based quantitative framework.

The ongoing COVID-19 pandemic has evolved beyond being a public health crisis as it has exerted worldwide severe economic impacts, triggering cascading failures in the global industrial network. Although certain powerful enterprises can remain its normal operation during this global shock, what's more likely to happen for the majority, especially those small- and medium-sized firms, is that they are experiencing temporary suspension out of epidemic control requirement, or even permanent closure due to chronic business losses. For those enterprises that sustain the pandemic and only suspend for a relatively short period, they could resume work and production when epidemic control and prevention conditions are satisfied and production and operation are adjusted correspondingly.

Mesoporous WS-Decorated Cellulose Nanofiber-Templated CuO Heterostructures for High-Performance Chemiresistive Hydrogen Sulfide Sensors.

There is a great demand to develop high-performance hydrogen sulfide (HS) sensors, especially at the trace level for environmental protection, human healthcare, and food freshness monitoring. To this end, cellulose nanofiber (CNF)-templated CuO (CuO-C) was decorated with tungsten disulfide (WS) nanosheets (W-Cu-C) as the sensing layer of chemiresistive microelectromechanical system (MEMS) sensors for HS recognition in this work. As compared to pristine CuO counterparts at 160.

Amine-Functionalized Black Phosphorus Nanosheets toward Ultrafast and Room-Temperature Trace Carbon Dioxide Sensing.

Carbon dioxide (CO) poses a significant effect on global climate, indoor activity, and crop yield, thus necessitating real-time and high-performance detection. Traditional CO-sensing materials always suffer from weak and sluggish reaction, elevated operation temperature, and poor detection limit. To surmount these obstacles, in this work a series of amine-rich polymer functionalized black phosphorus nanosheets (BP) were prepared for room-temperature CO detection.

Mechanistic Study of a Microwave Field-Controlled Static Crushing Agent for Efficient Rock Breaking.

The long reaction time and uncontrollable reaction process of the swelling agent in the process of rock breaking by static crushing agent lead to unsatisfactory efficiency and effect of rock breaking. This paper uses physical experiments to compare and analyze the changes in temperature and pressure of the hydration reaction under different microwave conditions; utilizes microscopic analysis of the hydration reaction products under each condition, combined with numerical calculations to elucidate the mechanism of the effect of microwave field on the hydration reaction of the expansion agent; and proposes a microwave field-controlled static crushing agent rock-breaking method. The study reached the following main conclusions: (1) microwave heating is better than conventional heating in terms of heating rate, peak temperature, and peak pressure; (2) using static crushing agent rock breaking is preferable to use a low-power microwave field to control the reaction process, and to ensure that the initial temperature is not higher than the local water boiling point; (3) microwave heating to promote the reaction mechanism lies in its deep heating of the system, faster heating rate, and higher energy utilization, and is more conducive to hydration expansion reaction; (4) selective heating of microwaves can enhance the hydration reaction of calcium oxide and inhibit the production of hydrated tricalcium silicate, making the reaction more complete, while microwave heating will also improve the microstructure of hydration products.

Mesoporous cellulose nanofibers-interlaced PEDOT:PSS hybrids for chemiresistive ammonia detection.

Chemiresistive ammonia (NH) detection at room temperature is highly desired due to the unique merits of easy miniaturization, low cost, and minor energy consumption especially for portable and wearable electronics. In this regard, poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) has sparked considerable attention due to the benign room-temperature conductivity and environmental stability, but it is undesirably impeded by limited sensitivity and sluggish reaction kinetics. To overcome these, we incorporated cellulose nanofibers (CNF) into PEDOT:PSS via a facile blending.

YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.

Oxaliplatin, as a first-line drug, frequently causes chemo-resistance in colorectal cancer (CRC). The role of N6-methyladenosine (m6A) modification in multiple biological functions has been well studied. However, the molecular mechanisms underlying m6A methylation in modulating anti-cancer drug resistance in CRC remain obscure.

Ag decoration-enabled sensitization enhancement of black phosphorus nanosheets for trace NO detection at room temperature.

Black phosphorus (BP), one rising star of two-dimensional (2D) materials, has showcased a huge capability for ppb-level NO detection. However, sluggish reaction kinetics and fragile stability frustrate its further application. In this regard, for the first time we prepared Ag nanoparticles modified BP nanosheets as the sensing layer via one feasible method to recognize trace NO at room temperature.