MUC5B regulates the airway inflammation induced by atmospheric PM in rats and A549 cells.

Atmospheric PM can induce airway inflammation and mucin secretion. MUC5B is required for airway defense. However, the research on the role of MUC5B in airway inflammation induced by atmospheric PM remains limited.

Cadmium bioaccumulation and distribution in the freshwater bivalve Anodonta woodiana exposed to environmentally relevant Cd levels.

Anodonta woodiana is a globally distributed freshwater bivalve, which is a unique bioindicator in the "Freshwater Mussel Watch" project. Numerous countries have used A. woodiana for biomonitoring the aqueous cadmium (Cd) contamination.

Underestimated humic acids release and influence on anaerobic digestion during sludge thermal hydrolysis.

Humic-like acids (HAs) are abundant in sewage sludge but mainly bonded with solids. Thus, their influences are often neglected in conventional digestion processes. Currently thermal hydrolysis pretreatment (THP) has been widely adopted in sludge anaerobic digestion (AD) to enhance hydrolysis of complex matters and further to improve methane production.

Clinical and Prognostic Significance of CD117 in Non-Small Cell Lung Cancer: A Systemic Meta-Analysis.

The aim of this study was to assess the relationship of cluster of differentiation 117 (CD117) expression with the clinicopathological characteristics and the prognosis in patients with non-small cell lung cancer (NSCLC). No meta-analysis concerning the correlation of CD117 expression with clinical and prognostic values of the patients with NSCLC is reported. A systematic literature search was conducted to achieve eligible studies.

Efficient recovery of phosphate from simulated urine by Mg/Fe bimetallic oxide modified biochar as a potential resource.

The massive use of phosphate fertilizers in agriculture is costly and induces water pollution, calling for more sustainable phosphate sources in the context of the circular economy. Here we prepared a new adsorbent based on waste straw biochar modified with the Mg/Fe bimetallic oxide, namely the Mg/Fe biochar, to recover phosphate from the simulated urine as an possible phosphate fertilizer. About 90% phosphate was recovered from the simulated urine with a wide pH range of 3.

Comprehensive role of thermal combined ultrasonic pre-treatment in sewage sludge disposal.

Thermal/ultrasonic pre-treatment of sludge has been proven to break the hydrolysis barriers of sewage sludge (SS) and improve the performance of anaerobic digestion (AD). In this study, the objective was to investigate whether the combination of two pre-treatment methods can achieve better results on the AD of SS. The results indicated that, compared with the control group and separate pre-treatment groups, the thermal combined ultrasonic pre-treatment presented more obvious solubilization of soluble proteins, polysaccharides, and other organic matters in SS.

Highly fluorescent nitrogen and boron doped carbon quantum dots for selective and sensitive detection of Fe.

Due to the essential role of Fe3+ in physiological and pathological processes, the detection of Fe3+ has drawn increasing attention in the field of disease diagnosis and environmental protection. However, most existing methods require either cumbersome sample pretreatment or sophisticated and expensive test equipment. Recently, carbon quantum dots have found a wide range of applications such as nanoprobes for Fe3+ determination, albeit with limited sensitivity and selectivity.

Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.

Genome-wide association studies (GWAS) for kidney function identified hundreds of risk regions; however, the causal variants, target genes, cell types, and disease mechanisms remain poorly understood. Here, we performed transcriptome-wide association studies (TWAS), summary Mendelian randomization, and MetaXcan to identify genes whose expression mediates the genotype effect on the phenotype. Our analyses identified Dachshund homolog 1 (DACH1), a cell-fate determination factor.

Status of Immunotherapy Acceptance in Chinese Patients With Multiple Sclerosis: Analysis of .

The prevalence of multiple sclerosis (MS) in China is low, although it has been increasing recently. Owing to the paucity of data on immunotherapy acceptance in the Chinese population, we conducted this study to analyze factors affecting the acceptance of immunotherapy and selection of disease-modifying therapies (DMTs) based on personal and clinical data of patients with MS. In this study, data were obtained from the , which was the first national survey of patients with MS in China.

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.

Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical reliance of gene expression on distal regulatory elements (enhancers).

Atomic Sulfur Filling Oxygen Vacancies Optimizes H Absorption and Boosts the Hydrogen Evolution Reaction in Alkaline Media.

The hydrogen evolution reaction (HER) usually has sluggish kinetics in alkaline solution due to the difficulty in forming binding protons. Herein we report an electrocatalyst in which sulfur atoms are doping in the oxygen vacancies (V ) of inverse spinel NiFe O (S-NiFe O ) to create active sites with enhanced electron transfer capability. This electrocatalyst has an ultralow overpotential of 61 mV at the current density of 10 mA cm and long-term stability of 60 h at 1.

Trade-off control of organic matter and disinfection by-products in the drinking water treatment chain: Role of pre-ozonation.

Ozone is a strong oxidant commonly used in drinking water treatment, but its role in the transformation/formation of organic matters (OMs) and disinfection by-products (DBPs) in the drinking water treatment chain had not been systematically studied. In this work the occurrence and building up of OMs, DBPs of trihalomethanes (THMs) and nitrosamines (NAs) during water purification steps under different pre-ozonation dosages have been studied through lab-scale and pilot-scale studies. Results indicated that 0-0.

Realizing Ultralong-Term Cyclicability of 5 Volt-Cathode-Material Graphite Flakes by Uniformly Comodified TiO/Carbon Layer Inducing Stable Cathode-Electrolyte Interphase.

A common issue the high-voltage cathode materials of secondary batteries suffered from is oxidative electrolyte decomposition inducing rapid capacity fading with discharge/charge cycling. Herein, a highly efficient strategy realizing stable cathode-electrolyte interphase (CEI) and ultralong-term cyclicability of 5 volt-cathode-material graphite flakes (GFs) for dual-ion batteries is demonstrated. The TiO/carbon-comodified GF (TO/GF) cathode material with uniform distribution and tight bonding of the nanosized TiO/carbon layer on the GF surface is synthesized, in which the GF surface is partitioned into nanodomains by the uniformly distributed TiO nanoparticles.

Molecular evidence of Candidatus Rickettsia longicornii and a novel Rickettsia strain from ticks in Southern China.

Ticks and tick-borne rickettsial diseases have been gaining greater attention in China over the past decade. However, most published studies to date have occurred in Northern China, with limited investigations occurring in China's southern provinces. As part of larger surveillance efforts, a cross-sectional survey was conducted in six sites at Guangdong, Guangxi and Yunnan investigating rickettsial infection in ticks.

MiRNA Polymorphisms and Hepatocellular Carcinoma Susceptibility: A Systematic Review and Network Meta-Analysis.

Background: Hepatocellular carcinoma (HCC) is an intractable public health threat worldwide, representing the second leading cause of cancer-related mortality, with limited early detection and therapeutic options. Recent findings have revealed that the susceptibility of HCC is closely related to microRNA (miRNA). We performed this systematic review with a network meta-analysis to investigated four single nucleotide polymorphisms (SNPs) that most regularly reported in miRNAs, exploring their involvement in HCC susceptibility and interaction with hepatitis B virus (HBV).

Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.

Background: Microscopic analysis of urine sediment is probably the most commonly used diagnostic procedure in nephrology. The urinary cells, however, have not yet undergone careful unbiased characterization.

Methods: Single-cell transcriptomic analysis was performed on 17 urine samples obtained from five subjects at two different occasions, using both spot and 24-hour urine collection.

extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease .

COVID-19 has become a global pandemic and there is an urgent call for developing drugs against the virus (SARS-CoV-2). The 3C-like protease (3CL) of SARS-CoV-2 is a preferred target for broad spectrum anti-coronavirus drug discovery. We studied the anti-SARS-CoV-2 activity of and its ingredients.

A novel near-infrared fluorescent probe based on isophorone for the bioassay of endogenous cysteine.

A dicyanoisophorone/acrylate-combined probe (DDP) was synthesized and designed as a near-infrared (NIR) fluorescent sensor for the rapid identification of Cys over Hcy and GSH in aqueous solution with a large Stokes shift (143 nm). The detection limit of Cys was 1.23 μM, which was lower than that of the intracellular Cys concentration.

The Nexus between Economic Complexity and Energy Consumption under the Context of Sustainable Environment: Evidence from the LMC Countries.

The wide application of various energy resources in economic development is allegedly responsible for deepening environmental deterioration in terms of increasing pollution emissions and other negative consequences including climate change. This current work investigates the interdependent correlation between energy consumption (both fossil fuel energy consumption and renewable energy consumption) and economic complexity among Lancang-Mekong Cooperation (hereafter LMC) countries, from 1991 to 2017. As for empirical analysis, a panel vector autoregression (PVAR) model was employed.

Altered serum levels of IL-36 cytokines (IL-36α, IL-36β, IL-36γ, and IL-36Ra) and their potential roles in Guillain-Barré syndrome.

Guillain-Barré syndrome (GBS) is an acute autoimmune neurological disorder mainly involving the peripheral nerves. Currently, various cytokines have been shown to be involved in the pathogenesis of GBS. Because of their similar biological structures, interleukin (IL)-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist (Ra) were all renamed and collectively called IL-36 cytokines.

Down-regulating microRNA-20a regulates CDH1 to protect against cerebral ischemia/reperfusion injury in rats.

Studies have extensively focused on the involvement of microRNAs (miRNAs) in cerebral ischemia/reperfusion (I/R) injury but not much on the specific role of miR-20a. Hence, this study is purposed to decipher whether miR-20a could regulate cadherin 1 (CDH1) to affect cerebral I/R injury in rats. Rat transient middle cerebral artery occlusion model (MCAO) was established.

Revealing hydrodynamics and energy efficiency of mixing for high-solid anaerobic digestion of waste activated sludge.

Anaerobic digestion is a feasible and promising technique to deal with emerging waste activated sludge issues. In this work, the hydrodynamics and digestion performance of horizontal anaerobic systems equipped with double-bladed impeller and ribbon impeller were investigated. Simulation using computational fluid dynamics technique visually showcased the favorable mixing status implementing ribbon impeller.

Simultaneous recovery of ammonium and total phosphorus from toilet tail water by modified palygorskite-bentonite clay.

Suitable treatment of toilet sewage is a worldwide challenge. The anaerobic baffled reactor (ABR)-microbial fuel cell (MFC)-microbial electrolysis cell (MEC) (AMM) coupling treatment system has been constructed achieving effective removal of carbon, nitrogen, and phosphorus from toilet sewage and resource recovery; however, ammonium (NH -N) and total phosphorus (TP) accumulation in tail water is a found problem of the system. In this study, acid-modified and alkali-heat modified palygorskite-bentonite (Pal-Ben) were used to recover NH -N and TP from the AMM toilet tail water simultaneously.

The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

Kidney disease is poorly understood because of the organ's cellular diversity. We used single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular composition but also in cell-type-specific gene expression in mouse models of kidney disease. This analysis highlighted major changes in cellular diversity in kidney disease, which markedly impacted whole-kidney transcriptomics outputs.