Utilisation of the Innovative [18F]-Labelled Radiotracer [18F]-BIBD-071 Within HR+ Breast Cancer Xenograft Mouse Models.

Aromatase plays a crucial role in the conversion of androgens to oestrogens and is often overexpressed in hormone-dependent tumours, particularly breast cancer. [18F]BIBD-071, which has excellent binding affinity for aromatase and good pharmacokinetics, has potential for the diagnosis and treatment of aromatase-related diseases. The MCF-7 cell line, which is hormone receptor-positive (HR+), was used in the assessment of the novel [18F]-labelled radiotracer [18F]BIBD-071 via positron emission tomography (PET) imaging of an HR+ breast cancer xenograft model.

Prediction of scleroderma renal crisis in patients of systemic sclerosis: insight from the CRDC cohort study.

Objective: Early personalized identification of systemic sclerosis (SSc) patients at risk for scleroderma renal crisis (SRC) can help provide better treatment and improve outcomes. This study aimed to create and validate a new multi-predictor nomogram to predict SRC risk and compare it to an existing model.

Methods: A retrospective multicentre observational study was conducted using clinical data from SSc patients with SRC registered in the Chinese Rheumatism Data Center (CRDC) database.

Chinese Registry of Rheumatoid Arthritis (CREDIT) VI: Temporal Trends in Patients With Early Rheumatoid Arthritis and Moderate-To-Severe Disease Activity - A Multicenter Cohort Study of Treatment Strategies and Outcomes.

Aim: The continuous update of international guidelines and enhanced availability of biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) have made a significant impact on the diagnosis and treatment of early rheumatoid arthritis (ERA). This study aims to systematically evaluate the current treatment strategies and outcomes within a large-scale cohort of patients with ERA.

Methods: Data from the Chinese Registry of Rheumatoid Arthritis (CREDIT), a large multicenter Chinese registry of RA, were collected to analyze temporal trends in clinical profiles, therapeutic strategies, and treatment outcomes among patients with ERA.

Engineered Au@MOFs silk fibroin-based hydrogel phototherapy platform for enhanced wound healing performance.

Wound bacterial infections not only impede the healing process but can also give rise to a range of serious complications, thereby posing a substantial risk to human health. Developing effective wound dressings incorporating phototherapy functionalities, specifically photothermal therapy (PTT) and photodynamic therapy (PDT), remains a critical area of research in modern wound care. Existing PTT-PDT systems often suffer from challenges such as nanoparticle aggregation and inefficient reactive oxygen species (ROS) generation, which are essential for therapeutic efficacy.

Oligo-FISH barcode chromosome identification system provides novel insights into the natural chromosome aberrations propensity in the autotetraploid cultivated alfalfa.

Alfalfa is one of the most economically valuable forage crops in the world. However, molecular cytogenetic studies in alfalfa lag far behind other cash crops and have reached a bottleneck. Here, we developed a novel chromosome identification system by designing 21 oligo probes in specific regions of each chromosome, which can be used as a barcode to simultaneously distinguish all chromosomes in a cell.

Light-/pH-Regulated Spiropyran Smart-Responsive Hydrophilic Separation Platform for the Identification of Serum Glycopeptides from Hepatocellular Carcinoma Patients.

Smart-responsive materials have attracted much attention in the enrichment of post-translational modifications of proteins. In this work, for the first time, we developed a smart enrichment strategy (MNPs-l-DOPA/PEI-SP) based on the change in hydrophilic properties of spiropyran under the regulation of light and pH to realize the controllable enrichment and release of intact glycopeptides. The enrichment mechanism and possible binding mechanism were verified by theoretical calculations.

Activated CdS/ sulfur doped g-CN photocatalyst for dye and antibiotic degradation: Experimental and DFT verification of S-scheme heterojunction.

To alleviate situation caused by azo dyestuff and antibiotics, a series of CdS/sulfur doped carbon nitride (GCNS) S-scheme heterojunction photocatalysts have been successfully fabricated by a pretty facile solid-state diffusion (SSD) method,. Under visible light, the optimal sample called CdS/GCNS-1:2 presented the best photodegradation rate of nearly 100% over methyl orange (MO), of which the reaction constant k was about 9.67 and 5.

Addressing high-performance data sparsity in metasurface inverse design using multi-objective optimization and diffusion probabilistic models.

Recent advancements in deep learning, particularly generative networks capable of producing high-freedom structures, have significantly enhanced the precise generation of meta-atoms. However, these methodologies typically rely on an abundance of high-performance data, which remains scarce in many practical design scenarios. To bridge this gap, our study introduces what we believe to be a novel approach that synergistically combines multi-objective optimization algorithms with an enhanced diffusion model featuring an attention mechanism, termed MetaDiffusion-Att.

The Photocleavable Protein PhoCl-Based Dynamic Hydrogels.

Dynamic protein hydrogels have attracted increasing attention owing to their tunable physiochemical and mechanical properties, customized functionality, and biocompatibility. Among the different types of dynamic hydrogels, photoresponsive hydrogels are of particular interest. Here, we report the engineering of a photoresponsive protein hydrogel by using the photocleavable protein PhoCl.

pH-sensitive metal-organic framework carrier decorated with chitosan for controlled drug release.

Satisfactory chemotherapeutic efficiency depends on improving the insufficient selectivity of chemotherapeutic drugs and decreasing damages to healthy tissues/cells, hence, the reasonable design and construction of drug carriers are of great significance in tumor treatment. Herein, the pH-sensitive MOF carrier was developed via the decoration of 4-formylphenylboronic acid (4-FPBA) for controlled 5'-deoxy-5-fluorocytidine (DFCR) release with selectivity. Besides, chitosan (CS) was introduced as the "gatekeeper" for the prevention of drug leakage.

Micro-Macro Coupling Study on the Mechanical Properties of Continuous Fiber-Reinforced Composites.

As a key and weak point of continuous fiber-reinforced composites (CFRCs), the interface between the fiber and the matrix is vulnerable to failure under external loads, with its performance directly affecting the overall properties of CFRCs. Hence, a micro-macro coupling method that considered the microscopic properties of the interface was utilized to analyze and predict the mechanical properties of CFRCs more accurately. The microscopic mechanical parameters of the fiber-matrix interface, which were obtained using molecular dynamics, were transferred to the representative volume element (RVE).

Knowledge, attitude, and practice of adolescents and parents toward malocclusion and orthodontic treatment.

Malocclusion is the misalignment of teeth and jaws, affecting oral health and appearance. This study aimed to examine the knowledge, attitude, and practice (KAP) of both adolescents and parents toward malocclusion. This web-based cross-sectional study was conducted at Tianjin between July 2019 and July 2022, enrolled adolescents and their parents.

The international empirics of management.

A country's national income broadly depends on the quantity and quality of workers and capital. But how well these factors are managed within and between firms may be a key determinant of a country's productivity and its GDP. Although social scientists have long studied the role of management practices in shaping business performance, their primary tool has been individual case studies.

Effective co-immobilization of arsenic and cadmium in contaminated soil by sepiolite-modified nano-zero-valent iron and its impact on the soil bacterial community.

Sepiolite-modified nano-zero-valent iron (S-nZVI) is used as an amendment and incubated to remediate As-Cd-contaminated soil under three different soil‒water management conditions [moderately wet (MW), continuously flooded (CF) and alternately wet and dry (AWD)]. The results showed that soil pH is in the order of CF > AWD > MW. The soil pH increased approximately 0.

Nonlinear association between alanine aminotransferase to high-density lipoprotein cholesterol ratio and risk of gestational diabetes mellitus.

Previous studies have indicated a potential association between the alanine aminotransferase to high-density lipoprotein cholesterol (ALT/HDL-C) ratio and the risk of Type 2 Diabetes Mellitus, but its relation with gestational diabetes mellitus (GDM) remains uncertain. This study aims to investigate the correlation between the ALT/HDL-C ratio in early pregnancy and the risk of GDM. This study is a secondary analysis based on an open-source cohort study.

Genome-Wide Identification of the Geranylgeranyl Pyrophosphate Synthase (GGPS) Gene Family Associated with Natural Rubber Synthesis in L. Rodin.

Rodin (TKS) is a recognized alternative source of natural rubber comparable to the rubber tree. The geranylgeranyl pyrophosphate synthase (GGPS) catalyzed the synthesis of geranylgeranyl pyrophosphate (GGPP), which is an important enzyme in the secondary metabolism pathway. In this study, we present the first analysis of the gene family in TKS, where a total of seven family members were identified.

Baseline gut microbiome as a predictive biomarker of response to probiotic adjuvant treatment in gout management.

Gout is characterized by dysregulation of uric acid (UA) metabolism, and the gut microbiota may serve as a regulatory target. This two-month randomized, double-blind, placebo-controlled trial aimed to investigate the additional benefits of coadministering Probio-X alongside febuxostat. A total of 160 patients with gout were randomly assigned to either the probiotic group (n = 120; Probio-X [3 × 10 CFU/day] with febuxostat) or the placebo group (n = 40; placebo material with febuxostat).

Cellulose / waste Cu-activated carbon composite: A sustainable and green material for boosting laccase activity and degradation of bisphenol A in wastewater.

Low enzyme activity is one of the disadvantages of immobilized laccase. In this study, waste Cu-loaded activated carbon (Cu-AC) was successfully used in preparing a novel composite support，cellulose / Cu-loaded activated carbon beads (C / Cu-AC)， and effectively boosted immobilized laccase activity. To achieve optimum conditions for immobilization of laccase, the immobilization time, pH and laccase concentration were examined.

RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis.

Purpose: Radioresistance is a significant challenge in the radiotherapy of non-small cell lung cancer (NSCLC). This study aimed to investigate the role of R-spondin 3 (RSPO3) in regulating NSCLC radioresistance.

Methods And Materials: RNA sequencing was performed to analyze genes that are differentially expressed in radioresistant NSCLC cell lines.