Publications by authors named "Hong-yue Jiang"
Background: Type 2 hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant disease and is associated with gene mutations. Type 2 HHT patients primarily suffer from recurrent bleeding. There is currently no promising treatment.
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- Cyclin C (CCNC) plays a role in regulating oxidative stress in mitochondria during cisplatin treatment, but its effects on gastric cancer are not well understood.
- The study utilized various assays to explore the interaction between cyclin C and HACE1, an E3 ubiquitin-protein ligase, and its implications for cisplatin resistance in gastric cancer cells.
- Results indicated that HACE1 ubiquitylates cyclin C, leading to increased mitochondrial fission and reactive oxygen species (ROS) production, which affects cell apoptosis and could inform treatment strategies for cisplatin resistance in gastric cancer patients.
To investigate the mitochondria-related mechanism of (GS)-induced apoptosis and the protective effect of phosphocreatine (PCr), a mitochondrial respiration regulator. First, the mechanism was explored in human hepatocyte cell line. The mitochondrial oxidative stress was determined by fluorescence assay.
View Article and Find Full Text PDFOncofetal genes are genes that express abundantly in both fetal and tumor tissues yet downregulated or undetected in adult tissues, and can be used as tumor markers for cancer diagnosis and treatment. Meanwhile, long noncoding RNAs (lncRNAs) are known to play crucial roles in the pathogenesis of hepatocellular carcinoma (HCC), including tumor growth, proliferation, metastasis, invasion, and recurrence. We performed a genome-wide screening using microarrays to detect the lncRNA expression profiles in fetal livers, adult livers, and liver cancer tissues from mice to identify oncofetal lncRNAs in HCC.
View Article and Find Full Text PDFHACE1 E3 ligase was discovered to be down-regulated in several cancers while its role in regulating tumors was merely understood. This study aimed to explore the specific effect of HACE1 played in gastric tumorigenesis and its potential mechanism. HACE1's expression was found significantly lower in gastric cancer tissues compared with the adjacent normal tissues (P < 0.
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- * Inhalable particles were identified as the main pollutants, with northern cities experiencing fewer clean days compared to southern cities due to heating practices and fuel use.
- * Air pollution peaks in winter due to factors like low rainfall and high energy consumption, while spatial analysis reveals high pollution clusters in northern China and low pollution clusters in the south, influenced by climate and industrial activities.
[An outbreak of imported dengue fever from Myanmar to the border of China, with its viral molecular epidemiological features].
Zhonghua Liu Xing Bing Xue Za Zhi
May 2013
Objective: To understand the epidemiologic characteristics of dengue fever, imported from Myanmar to the border of Yunnan province, China. Viral molecular epidemiologic features were also studied.
Methods: Questionnaires were used on each diagnosed, suspected dengue fever, case or unknown cases with fever when coming from Myanmar entering the port and hospitals in Ruili city of Yunnan province.
Objective: To sequence and analyze the complete genome of two new Japanese encephalitis virus (JEV) strains isolated from mosquitoes collected in Hubei province in 2008, and to understand the molecular biological characteristics of JEV in this area.
Methods: RT-PCR was used to amplify the fragments of HBZG08-09 strain and HBZG08-55 strain with 16 pairs overlapping primers after they had been recovered and identified, then the full-length genome was obtained by sequencing and splicing. Biological sequence alignment, nucleotide and amino acid sequence analysis, phylogenetic analysis and analysis of amino acid differences were performed by the software of Clustal X (1.