Publications by authors named "Hong-yuan Zhou"
Article Synopsis
- Congenital cytomegalovirus (cCMV) is a common viral infection in newborns, with maternal CMV serology tests typically starting with IgM and IgG antibody assessment.
- In a study of five perinatal cases, cCMV was diagnosed in fetuses despite negative maternal IgM results during the second trimester, highlighting the limitations of this test.
- The findings suggest that a negative maternal CMV IgM does not rule out cCMV, making prenatal CMV testing important along with autopsy and placental evaluations for unexplained fetal issues.
Background And Objectives: There is a growing infectious syphilis outbreak in Western Canada. Although blood donors are screened for syphilis risks, some blood donors will still be confirmed test-positive for syphilis. This study compares the characteristics of confirmed test-positive syphilis donations in both Western Canada and Eastern Canada, November 2022-August 2023.
View Article and Find Full Text PDFBackground: In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5 years, 1 year, 3 months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12 years.
Study Design And Methods: Syphilis positivity in 10,288,322 whole blood donations (January 1, 2010-September 10, 2022) and gbMSM deferral time periods, donation status, age, and sex were analyzed with logistic regression.
Retrospective testing for the presence of monkeypox virus in a high-risk population from February-June 2022 in Alberta, Canada.
J Assoc Med Microbiol Infect Dis Can
March 2023
Background: A multi-country outbreak of monkeypox virus (MPXV) infections was identified by the World Health Organization in May 2022. The western Canadian province of Alberta identified its first case of MPXV in a returning traveller on June 2, 2022. We undertook a retrospective testing exercise to evaluate whether MPXV may have been circulating in the province earlier.
View Article and Find Full Text PDF[Protective mechanism of tetramethylpyrazine on cardiovascular system].
Zhongguo Zhong Yao Za Zhi
March 2023
Tetramethylpyrazine is the main component of Ligusticum chuanxiong. Studies have found that tetramethylpyrazine has a good protective effect against cardiovascular diseases. In the heart, tetramethylpyrazine can reduce myocardial ischemia/reperfusion injury by inhibiting oxidative stress, regulating autophagy, and inhibiting cardiomyocyte apoptosis.
View Article and Find Full Text PDFArticle Synopsis
- - The study assessed an AI algorithm's effectiveness in detecting breath sounds in children with pulmonary diseases, using data collected at the Shanghai Children's Medical Center from May to December 2019.
- - A total of 112 children contributed 672 breath sound recordings, with the AI showing a detection accuracy of 77.7%, significantly outperforming general pediatricians who had an accuracy of 59.9%.
- - Results indicated that the AI's performance varied by patient age, with the highest accuracy (81.3%) observed in children under 12 months, especially in identifying specific sounds like crackles and wheezes.
Article Synopsis
- Taraxacum mongolicum is a traditional Chinese medicine known for its use in treating inflammatory and infectious diseases, including mastitis, but its mechanisms of action remain unclear.
- The study aimed to uncover the protective effects and mechanisms of T. mongolicum against mastitis caused by Staphylococcus aureus in mice.
- Results showed that T. mongolicum reduced inflammatory cytokines, improved tissue health, and inhibited specific signaling pathways linked to inflammation, suggesting its potential as a treatment for mastitis.
Toxoplasmosis is an uncommon congenital infection in Canada, but one with potentially severe clinical manifestations, including fetal death. Neurologic and ocular manifestations are frequent in untreated disease; however, small eye size (microphthalmia) is a rare finding. This finding may be a marker of severe ocular disease.
View Article and Find Full Text PDFPurpose: We retrospectively evaluated the efficacy and safety of apatinib as a first-line treatment for advanced hepatocellular carcinoma (HCC) and explored whether drug-related hypertension (HTN) could predict its efficacy.
Patients And Methods: This retrospective analysis included patients with advanced HCC who received oral treatment with apatinib. We evaluated the effectiveness by overall survival (OS), progression-free survival (PFS), time to progression (TTP), and disease control rate (DCR), and assessed the safety of the drug based on the occurrence of adverse events.
Article Synopsis
- Non-parasitic hepatic cysts with biliary communication are rare and tricky to diagnose due to non-specific symptoms, as illustrated by a case of a 70-year-old woman experiencing abdominal discomfort.
- An MRI revealed a large cystic lesion in the liver, leading to surgical exploration where it was discovered that the cyst was connected to the biliary tract.
- The surgical treatment involved resection of the cyst wall and repair of the biliary fistula, resulting in a smooth recovery for the patient without complications post-surgery.
Correlations of tumor-associated macrophage subtypes with liver metastases of colorectal cancer.
Asian Pac J Cancer Prev
July 2014
Objective: This work aimed to investigate the correlations of tumor-associated macrophages (TAMs) and their subtypes M1 and M2 with liver metastasis of colorectal cancer, and provide useful references for seeking predictors of liver metastasis and studying mechanisms.
Methods: 120 patients with colorectal cancer from 2000 to 2009 were divided into low, middle and high liver metastasis groups (group A, B and C, respectively). S-P immunohistochemical staining and microscopic observation were conducted to compare expression in CD68- positive cells (TAMs), CD80-positive cells (M1) and CD163-positive cells (M2) in three groups.
[Influencing factors for intrahepatic distant recurrence of liver cancer after radiofrequency ablation].
Zhonghua Wai Ke Za Zhi
October 2009
Article Synopsis
- The objective of the study was to identify factors that influence the risk of intrahepatic distant recurrence in liver cancer patients after undergoing radiofrequency ablation (RFA).
- A total of 80 patients were analyzed, revealing that recurrence rates significantly increased over time, with a 67.3% rate at 5 years.
- Key risk factors found include high levels of serum AFP and DCP, insufficient ablative margins, and poor Child-Pugh grade, indicating the need for careful monitoring and sufficient margins during RFA to reduce recurrence risks.
Article Synopsis
- The study investigates how interferon alpha (IFNalpha) affects tumor endothelial cells (TECs) in a model of highly metastatic hepatocellular carcinoma (HCC).
- Treatment with IFNalpha led to reduced tumor growth, decreased blood vessel density, and increased apoptosis in TECs, indicating a normalization of tumor blood vessels.
- Gene expression analysis showed that IFNalpha alters TECs' behavior by inhibiting their adhesion and uptake capabilities, suggesting it plays a role in anti-angiogenesis and slowing tumor progression.
[Metastatic cutaneous melanoma to palatine tonsil: report of a case].
Zhonghua Bing Li Xue Za Zhi
May 2008
[Effects of selected phages with specific peptide ligands on the biological behaviors of ovarian cancer cells].
Zhonghua Fu Chan Ke Za Zhi
October 2005
Article Synopsis
- The study assessed how specific phages with peptide ligands impact ovarian cancer cells, using two cell lines (A2780 and SKOV3) categorized into different groups for comparison.
- The findings showed that the phages reduced cell viability (average 72.1% vs. 84.8% in controls) and increased apoptosis rates, indicating enhanced cell death in the study groups.
- Additionally, phages led to lower colony formation rates (4% vs. 15% in controls) and a decrease in invasive behavior, suggesting these phages may hinder ovarian cancer progression and metastasis.
[A Chinese autosomal dominant polycystic kidney disease family probably related to PKD2 gene].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2005
Objective: To study the genetic heterogeneity of autosomal dominant polycystic kidney disease (ADPKD) in Chinese.
Methods: Using polymerase chain reaction (PCR) and non-denatured polyacrylamide gel electrophoresis, the authors analyzed eight microsatellite markers closely linked to PKD1 or PKD2 genes respectively in a Chinese ADPKD family.
Results: Seven informative markers were found in this family, including KG8, SM6, CW4 and CW2 which are tightly linked to PKD1, and D4S1563, D4S414 and D4S423 which are linked to PKD2.
Article Synopsis
- The study investigates the expression of small heat shock proteins (sHsps) in normal and cleft palates during mouse embryonic development.
- Mice embryos were treated with retinoic acid and vegetable oil, and the abundance of various sHsps was measured using RT-PCR between gestational days 15 and 17.
- Results showed distinct expression patterns of sHsps in normal and cleft palates, suggesting that certain sHsps may have protective roles against stress in cleft palate formation.
Article Synopsis
- The study aimed to identify specific targets on the surface of epithelial ovarian cancer cells using a peptide phage display library.
- After several rounds of incubating the library with normal ovarian cells and then cancer cell lines, positive clones that bound to the cancer cells were isolated and analyzed.
- Ultimately, 10 positive clones were selected, with one candidate sequence (YYGLAEVDAGGS) identified as a target for further research.