"Intensity-response" effects of electroacupuncture on gastric motility and its underlying peripheral neural mechanism.

The aim of this study was to explore the "intensity-response" relationship between EAS and the effect of gastric motility of rats and its underlying peripheral neural mechanism by employing ASIC3 knockout (ASIC3-/-), TRPV1 knockout (TRPV1-/-), and C57BL/6 mice. For adult male Sprague-Dawley (n = 18) rats, the intensities of EAS were 0.5, 1, 3, 5, 7, and 9 mA, respectively.

[Effects of transcutaneous electrostimulation of auricular concha at different stimulating frequencies and duration on acute seizures in epilepsy rats].

Objective: To observe the inhibitory effect of auricular concha transcutaneous electrostimulation (ACTES) of different frequencies and duration on acute seizures in epilepsy rats so as to select a better stimulating parameter for relieving epilepsy.

Methods: According to the stimulation duration of ACTES, 44 Sprague-Dawley rats were randomized into: 30 s, 5 min, 10 min, and 30 min groups. Epilepsy model was duplicated by intraperitoneal injection of PTZ (pentylenetetrazol, 50 mg/kg).

[Effects of electroacupuncture and regional thermal stimulation at "Zusanli" (ST 36) on pain thresholds of TRPV 1 knock-out mice].

Objective: To observe the effect of electroacupuncture (EA) and moxibustion-like thermal stimulation with different temperatures at "Zusanli" (ST 36) on pain reactions in transient receptor potential vanilloid type 1 knock-out (TRPV 1 -/-) mice so as to study its mechanisms underlying analgesia.

Methods: Ten C 57 BL/6 mice and 10 TRPV 1 -/- mice were respectively divided into control and TRPV 1 -/- groups. EA (0.

[Effect of electroacupuncture on cortical spreading depression and plasma CGRP and substance P contents in migraine rats].

Objective: To observe the effect of electroacupuncture (EA) on cortical spreading depression (CSD) and contents of plasma calcitonin gene-related peptide (CGRP) and substance P (SP) in migraine rats.

Methods: Thirty male SD rats were equally randomized into control, model and EA groups. Migraine model was established by topical application of KCI (3 mol/L) immersed in a piece of filter paper to the cerebral cortex (parietal lobe, 6 mm posterior to the Bregma and 5 mm to the sagital fissure) after exposure of the skull (in reference to Michael' method).