Publications by authors named "Hong-yan Fan"
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a serious genetic heart condition linked to sudden death and heart failure, and thyroid dysfunction may worsen heart-related risks.
- A study of 782 HCM patients investigated the impact of thyroid hormone levels, specifically focusing on those with low triiodothyronine (low T3 syndrome), to determine their role in predicting adverse outcomes.
- Results indicated that patients with low T3 syndrome experienced significantly higher rates of sudden cardiac death and worsening heart failure events, highlighting low T3 syndrome as a strong predictor for these serious health issues.
Article Synopsis
- Researchers collected and sterilized samples from diseased plants to isolate and identify the responsible pathogen, obtaining four distinct Gram-negative bacterial colonies via lab culture techniques.
- Genetic analysis, including 16S rDNA sequencing, showed high similarity to known reference strains, confirming the pathogen's identity and contributing to the understanding of the disease affecting jackfruit.
Article Synopsis
- Jackfruit is a major tropical fruit crop in Hainan, China, but it faces a serious threat from bronzing disease, which affects around 80% of trees in orchards once it appears, causing discoloration of the fruit.
- Previous reports of this disease have been documented in other countries, highlighting its widespread impact across regions like the Philippines, Malaysia, and Mexico.
- Research methods involved sterilizing infected samples, culturing them on specific agar mediums, and conducting PCR tests, which confirmed the presence of the causative agent, P. stewartii subsp. stewartii, with high genetic similarity to known strains.
Background: Hypertrophic cardiomyopathy (HCM) is the prevalent inherited cardiomyopathy and a major contributor to sudden death and heart failure in young adults. Although depression has been associated with poor prognosis in patients with cardiovascular disease, the relationship between anxiety and HCM clinical outcomes has not been addressed. We aimed to determine the prevalence of anxiety symptoms in patients with HCM and the association between anxiety and adverse prognosis in this population.
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- The B3 superfamily consists of large transcription factors in plants that influence growth and flowering, yet their role in ethylene-induced flowering in pineapple hasn't been previously studied.
- Researchers identified 57 B3 genes in pineapples, classified them into five subfamilies, and found that most were located on 21 linkage groups with evidence of segmental duplication in their evolution.
- Analysis showed that many B3 genes respond to hormones and stress, with 35 of them being up-regulated after ethylene treatment, suggesting their involvement in the flowering process.
Keratin 18 induces proliferation, migration, and invasion in gastric cancer via the MAPK signalling pathway.
Clin Exp Pharmacol Physiol
January 2021
Purpose: Keratin 18 (KRT18) is a cytoskeleton protein that plays a key role in multiple cancers. The present study aims to further investigate the roles of KRT18 in gastric cancer (GC) tissues and cells.
Methods: The KRT18 protein expression levels of GC tissues and cells were detected using immunohistochemistry and western blot.
Transmission line pulse transformers have been widely used in pulsed power technology. Traditional transmission line pulse transformers often use separate structures, which always introduces larger spurious parameters, and have lower voltage levels. In order to solve these problems, this note proposes a coaxial transmission line pulse transformer.
View Article and Find Full Text PDFAim: To investigate the significance of endothelial progenitor cells (EPCs) in predicting severe acute pancreatitis (SAP).
Methods: We recruited 71 patients with acute pancreatitis (AP) and excluded 11 of them; finally, cases of mild acute pancreatitis (MAP) ( = 30) and SAP ( = 30), and healthy volunteers ( = 20) were internalized to investigate levels of EPCs, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), fibrinogen (FIB) and white blood cells (WBC) in peripheral blood.
Results: The levels of TNF-α, WBC, FIB and CRP were higher both in SAP and MAP cases than in healthy volunteers ( < 0.
[Effect of flavonoids from Sophora flavescens in aging mice induced by D-galactos].
Zhongguo Zhong Yao Za Zhi
November 2015
To investigate the effect of flavonoids from Sophora flavescens in aging mice induced by D-galactose and its mechanism. Totally 60 mice were randomly divided into six groups: the control group, the model group, the piracetam group (positive control group) and flavonoids from S. flavescens low, medium and high doses groups.
View Article and Find Full Text PDFWith a great difference in therapeutic effects of Mahuang (MH, the stems of Ephedra sinica) and Mahuanggen (MHG, the roots of Ephedra sinica), chemical differences between MH and MHG should be investigated. In the present study, gas chromatography-mass spectrometry (GC-MS)-based plant metabolomics was employed to compare volatile oil profiles of MH and MHG. The antioxidant activities of volatile oils from MH and MHG were also compared.
View Article and Find Full Text PDFBackground: Endogenous estrogens play an important role in the development of breast cancer. Octylphenol (OP) and genistein (GEN) are estrogen-like chemicals. Prepubertal estradiol and genistein exposure can up-regulate BRCA1 mRNA in mammary gland and reduce futuer breast cancer risk.
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