Functional crosstalk of sucrose and G protein signaling in maize thermotolerance by modulating osmoregulation system.

Sucrose (SUC) is a signaling molecule with multiple physiological functions. G protein is a kind of receptor that converts extracellular first messenger into intracellular second messenger. However, it is little known that SUC interplays with G protein signaling in maize thermotolerance.

From hate to harmony: Leveraging large language models for safer speech in times of COVID-19 crisis.

This study investigates the rampant spread of offensive and derogatory language during the COVID-19 pandemic and aims to mitigate it through machine learning. Employing advanced Large Language Models (LLMs), the research develops a sophisticated framework adept at detecting and transforming abusive and hateful speech. The project begins by meticulously compiling a dataset, focusing specifically on Chinese language abuse and hate speech.

Construction of CsAgBiCl/COF Heterojunction for Boosted Photocatalytic Thioester Oxidation.

Lead-free halide perovskites as a new kind of potential candidate for photocatalytic organic synthesis have attracted much attention recently. The rational heterojunction construction is regarded as an efficient strategy to delicately regulate their catalytic performances. Herein, a semi-conductive covalent organic framework (COF) nanosheet, CN, is employed as the functional component to construct CsAgBiCl/CN (CABC/CN) heterojunction.

In Situ Loading of Cu Nanocrystals on CsCuCl for Selective Photoreduction of CO to CH.

Rational design and facile synthesis of efficient environmentally friendly all-inorganic lead-free halide perovskite catalysts are of great significance in photocatalytic CO reduction. Aiming at photogenerated charge carrier separation and CO reaction dynamics, in this paper, a CsCuCl /Cu nanocrystals (NCs) heterojunction catalyst is designed and synthesized via a simple acid-etching solution process by using Cu O as the sacrificed template. Due to the disproportionation reaction of Cu O induced by concentrated hydrochloric acid, Cu NCs can be deposited onto the surface of CsCuCl microcrystals directly and tightly.

Deubiquitinase USP47 attenuates virus-induced type I interferon signaling.

The innate immune responses are tightly regulated to ensure effective clearance of invading pathogens and avoid excessive inflammation. Ubiquitination and deubiquitination are important post-translational modifications in antiviral immune responses. Here, we discovered deubiquitinase USP47 as a novel negative immune system regulator.

Trajectories of oxygen saturation within 6-72 hours after birth in neonates at moderate altitude: a prospective longitudinal cohort study.

Background: Trajectories of pulse oxygen saturation (SpO) within the first few days after birth are important to inform the strategy for identifying asymptomatic hypoxemic disease but remain poorly substantiated at higher altitudes.

Methods: We performed a longitudinal cohort study with consecutive neonates at a local hospital in Luchun County, China, at an altitude of 1650 m between January and July 2020. We repeatedly measured the pre- and post-ductal SpO values at 6, 12, 18, 24, 36, 48, and 72 hours after birth for neonates without oxygen supplements.

Exosomes from artesunate-treated bone marrow-derived mesenchymal stem cells transferring to promote osteogenesis via TAF15-RUNX2 pathway.

Effect of artesunate (ART)-treated bone marrow-derived mesenchymal stem cells-derived exosomes (BMSC-Exos) on osteogenesis and its underlying mechanisms were investigated. Proliferation, alkaline phosphatase activity and calcified nodule formation of osteoblasts were determined. A mouse model of osteoporosis was established by ovariectomy.

Inorganic Copper-Based Halide Perovskite for Efficient Photocatalytic CO Reduction.

In view of the toxicity of the Pb element, exploring eco-friendly Pb-free halide perovskites with excellent photoelectric properties is of great research and practical application significance. Herein, copper-based halide perovskite CsCuCl and the corresponding Br-substituted sample (CsCuClBr) are designed and explored as the catalysts for photocatalytic CO reduction for the first time. A facile antisolvent recrystallization process with pre-prepared single crystals as the precursor is employed to controllably synthesize CsCuCl and CsCuClBr microcrystals (MCs).

Metagenomic analysis of viral diversity and a novel astroviruse of forest rodent.

Background: Rodents are important virus reservoirs and natural hosts for multiple viruses. They are one of the wild animals that are extremely threatening to the spread of human viruses. Therefore, research on rodents carrying viruses and identifying new viruses that rodents carry is of great significance for preventing and controlling viral diseases.

Sulfur Dioxide: An Emerging Signaling Molecule in Plants.

Sulfur dioxide (SO) has long been viewed as toxic gas and air pollutant, but now is being verified as a signaling molecule in mammalian cells. SO can be endogenously produced and rapidly transformed into sulfur-containing compounds (e.g.

Reactivation of γ-globin expression using a minicircle DNA system to treat β-thalassemia.

Reactivation of fetal hemoglobin by editing the B-cell lymphoma/leukemia 11A (BCL11A) erythroid enhancer is an effective gene therapy for β-thalassemia. Using the CRISPR/Cas9 system, fetal γ-globin expression can be robustly reactivated to mitigate the clinical course of β-thalassemia. In our study, we found that the transfection efficiencies of CD34 hematopoietic stem/progenitor cells (HSPCs) were significantly and negatively correlated with the length of plasmids and greatly affected by the linearization of plasmids.

Knockdown of YKL-40 inhibits angiogenesis through regulation of VEGF/VEGFR2 and ERK1/2 signaling in endometrial cancer.

Studies have demonstrated that small interfering RNA (siRNA) targeting YKL-40 (siYKL-40) inhibits the proliferation, migration, invasion, and induces antiapoptotic abilities of endometrial cancer (EC) HEC-1A cells. However, its effect on angiogenesis is unclear. The present study aimed to investigate the role of YKL-40 in endometrial cancer and the related molecular mechanisms.

Upregulation of oncogene Activin A receptor type I by Helicobacter pylori infection promotes gastric intestinal metaplasia via regulating CDX2.

Background: Activin A receptor type I (ACVR1) is involved in tumorigenesis. However, the underlying molecular mechanisms of ACVR1 in gastric cancer (GC) and its association with Helicobacter pylori remained unclear.

Materials And Methods: The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) database were utilized to explore the ACVR1 expression in GC and normal control and its association with survival.

Surface passivated halide perovskite single-crystal for efficient photoelectrochemical synthesis of dimethoxydihydrofuran.

Halide perovskite single-crystals have recently been widely highlighted to possess high light harvesting capability and superior charge transport behaviour, which further enable their attractive performance in photovoltaics. However, their application in photoelectrochemical cells has not yet been reported. Here, a methylammonium lead bromide MAPbBr single-crystal thin film is reported as a photoanode with potential application in photoelectrochemical organic synthesis, 2,5-dimethoxy-2,5-dihydrofuran.

Establishment of multiplex allele-specific blocker PCR for enrichment and detection of 4 common mutations in non-small cell lung cancer.

Background: Lung cancer is one of the most severe cancers and the majority of patients miss the best timing for surgery when diagnosed, thus having to rely on radiotherapy, chemotherapy or target therapy. Epidermal growth factor receptor (EGFR) upregulation occurs in a large percentage of patients, who can then benefit from tyrosine kinase inhibitors (TKI). However, the EGFR mutations they carry will vary the effectiveness of TKI.

Caudal type homeoboxes as a driving force in infection-induced gastric intestinal metaplasia.

(), a common pathogenic bacterium in the stomach, has been demonstrated to be a major cause of gastric cancer (GC). The typical pathological evolution of infection-induced GC involves development from gastric atrophy, via intestinal metaplasia (IM) and dysplasia, to intestinal-type GC. During this process, IM is considered to be an "irreversible point" that significantly increases the risk for GC.

[Change laws of water absorption in Chinese herbal pieces and prediction model of relative density for Chinese medicine decoction].

This study aims to explore the change laws of water absorption in Chinese herbal pieces and establish the prediction model of relative density for Chinese medicine compound decoction. Firstly, fitted equations of water absorption and decocting time was established by observing the change laws of water absorption in 36 kinds of Chinese herbal pieces in 12 groups(according to the drug-parts) with decocting time. The r value of the mineral group and other type group was 0.

Facile synthesis of platinum-rhodium alloy nanodendrites as an advanced electrocatalyst for ethylene glycol oxidation and hydrogen evolution reactions.

Direct ethylene glycol fuel cells (DEGFCs) and water splitting devices have received intensive interest during the past few decades. However, the commonly used Pt catalysts are seriously restricted by the high cost and very low resistance to CO-like intermediates during the catalysis. Herein, a general and simple solvothermal method was developed to synthesize three-dimensional (3D) bimetallic alloyed PtRh nanodendrites (NDs) for ethylene glycol oxidation reaction (EGOR) and hydrogen evolution reaction (HER).