Publications by authors named "Hong-meng Zhao"

The effects of temperature and phosphate fertilizer application on wheat seedling growth and soil inorganic phosphorus transformation in calcareous fluvo-aquic soil were examined in a pot experiment. The results showed that temperature and phosphorus were important factors affecting wheat growth but without significant interaction. The effect of temperature on wheat growth was greater than that of phosphate fertilizer, and 15 ℃ was the suitable temperature for wheat seedling.

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Background: Molecular subtype of breast cancer is associated with sentinel lymph node status. We sought to establish a mathematical prediction model that included breast cancer molecular subtype for risk of positive non-sentinel lymph nodes in breast cancer patients with sentinel lymph node metastasis and further validate the model in a separate validation cohort.

Methods: We reviewed the clinicopathologic data of breast cancer patients with sentinel lymph node metastasis who underwent axillary lymph node dissection between June 16, 2014 and November 16, 2017 at our hospital.

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Delta-aminolevulinate dehydratase (ALAD) catalyzes the second step in the biosynthesis of heme and is also an endogenous inhibitor of the 26S proteasome. The role of ALAD in breast cancer progression is still unclear. In this study, we found that the expression of ALAD was downregulated in breast cancer tissues compared with adjacent normal breast tissues.

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Background: This study determined whether axillary ultrasound (AUS) accurately predicted the status of axillary lymph nodes of patients who received different number of cycles of neoadjuvant chemotherapy (NAC).

Materials And Methods: From 2008 to 2015, 656 cases of patients with breast cancers who received NAC and had subsequent axillary lymph node dissection were included in this study. The findings of preoperative AUS were tested by pathological examination.

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The aim of the present study was to evaluate the association between mammographic features and clinicopathological characteristics in invasive ductal carcinoma. A total of 231 patients were retrospectively reviewed from January, 2011 to December, 2012. Statistical analysis was performed using Fisher's exact test, χ test, Spearman's correlation and logistic regression, as appropriate.

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Article Synopsis
  • - FOXD3 is identified as a tumor suppressor that is crucial for regulating the development and aggression of breast cancer cells, but its specific role in breast tumorigenesis is not well understood.
  • - Research shows that FOXD3 levels are lower in breast cancer tissues, and patients with decreased FOXD3 expression tend to have worse outcomes; its depletion encourages cancer cell growth and invasion.
  • - Enhancing FOXD3 expression can reduce breast cancer cell proliferation and invasion, suggesting its potential as a therapeutic target for improving breast cancer treatments.
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Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited.

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Purpose: The aquaporin (AQP) family consists of a number of small integral membrane proteins that transport water and glycerol. AQPs are critical for trans-epithelial fluid transport. Recent reports demonstrated that AQPs, particularly AQP1 and AQP5, are expressed in high grade tumor cells of a variety of tissue origins, and that AQPs are involved in cell migration and metastasis.

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Objective: To investigate the effect of gefitinib on the migration of triple-negative breast cancer cell line MDA-MB-231 cells.

Methods: Gefitinib was used in concentrations of 0 micromol/L, 0.1 micromol/L, 1 micromol/L, 10 micromol/L and 20 micromol/L, respectively.

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Objective: To study the effect of ABT-737 combined with cisplatin on apoptosis of breast cancer cell line T47D cells.

Methods: T47D cells cultured in vitro was used for this experiment. Cell proliferation was measured by MTT assay.

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Objective: To study the clinical significance of extracapsular extension (ECE) of axillary lymph node metastases in breast cancer.

Methods: The clinicopathological data of 1230 cases of nodal positive breast cancer treated in our department from 1989 to 1995 were analyzed retrospectively.

Results: 486 (39.

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