Publications by authors named "Hong-mei Zhu"
While microRNAs (miRs) like miR-9 are crucial for neurogenesis and neuronal differentiation, their regulatory mechanisms are not well understood. miR-9 is highly expressed in the brain and plays a significant role in neurogenesis. Using the Collaborative Cross resource, we identified significant quantitative trait loci (QTL) through genetic analyses.
View Article and Find Full Text PDFBackground: Currently, there is a lack of global or even country/regional level data on adolescent non-alcoholic fatty liver disease (NAFLD) prevalence. However, an evidenced dose-dependent relationship exists between body mass index (BMI) and the risk of NAFLD. We aim to estimate the global and regional prevalence of adolescent NAFLD and related non-alcoholic steatohepatitis (NASH) based on BMI.
View Article and Find Full Text PDFObjective: To systematically evaluate the diagnostic accuracy of magnifying endoscopy combined with narrowband imaging (ME-NBI) in detecting early gastric cancer (EGC) and to provide a scientific basis for its clinical utility.
Methods: Literature published before May 2024 that utilized ME-NBI for diagnosing EGC was searched across PubMed, EMBASE, The Cochrane Library, Web of Science, and major Chinese databases. Included studies were cohort studies or randomized controlled trials, and their quality was assessed using the QUADAS-2 framework.
Mycotoxins are ubiquitous natural pollutants that pose a serious threat to public health. Deoxynivalenol (DON) as one of the most prominent mycotoxins has a noticeable adverse effect on intestinal barrier function, which depends on the intestinal barrier integrity. However, the potential mechanisms and effective therapeutic strategies remain unclear.
View Article and Find Full Text PDFBackground: At present, there is a dearth of comprehensive data at the global, national, and regional levels regarding the adult non-alcoholic fatty liver disease (NAFLD) prevalence. This cross-sectional study aims at ascertaining the prevalence of NAFLD and non-alcoholic steatohepatitis (NASH), utilizing body mass index (BMI) as a determining factor.
Methods: Based on the NHANES database, sigmoidal fitting curves were generated to establish the relationship between BMI and the risk of NAFLD/NASH.
Background: Limited research has explored the associations of gestational age (GA) and breastfeeding practices with growth and nutrition in term infants.
Methods: This multicenter cross-sectional study recruited 7299 singleton term infants from well-child visits in Shandong, China, between March 2021 and November 2022. Data on GA, gender, ethnicity, birth weight, parental heights, gestational diabetes and hypertension, age at visit, breastfeeding practices (point-in-time data at visit for infants < 6 months and retrospective data at 6 months for infants ≥ 6 months), complementary foods introduction, infant length and weight, were collected.
Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer to enhance the plasticity and durability of agricultural products, which pose adverse effects to human health and the environment. Aquaporin 1 (AQP1) is a main water transport channel protein and is involved in the maintenance of intestinal integrity. However, the impact of DEHP exposure on gut health and its potential mechanisms remain elusive.
View Article and Find Full Text PDFPurpose: Prostate-specific membrane antigen (PSMA)-targeted imaging has gained increasing interest in its application in prostate cancer lesion detection. Compared with Galium (Ga), Fluoride (F)-labeled imaging agent has easier syntheses, lower price, and a longer half-time. 2-(3-{1-Carboxy-5-[(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid positron emission tomography (F-DCFPyL PET) has been recently approved by the U.
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- The study investigated how NISCH expression relates to skin cutaneous melanoma (SKCM) and its effect on melanoma cell behavior and clinical characteristics.
- The research found that NISCH levels were significantly lower in SKCM tissues compared to normal skin and correlated with factors like sex and disease stage.
- Overexpressing NISCH in melanoma cells reduced aggressive behaviors, such as migration and invasion, likely through the PAK1 signaling pathway, suggesting it could be a viable target for melanoma treatment.*
Objective: This study aimed to investigate the role of Interleukin-11 receptor alpha (IL11RA) in skin cutaneous melanoma (SKCM) metastasis to the liver.
Methods: Human SKCM cell lines (A375, A375-MA2, SK-MEL-28, RPMI-7951) and primary dermal fibroblasts (HDFa) were utilized to assess IL11RA expression. IL11RA siRNA was transfected into RPMI-7951 and A375-MA2 cells for Wound healing and Transwell invasion assays.
Di-(2-ethylhexyl) phthalate (DEHP), as the most common phthalate, has been extensively used as a plasticizer to improve the plasticity of agricultural products, which pose severe harm to human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed to explore the effect of DEHP on the nervous system and its association with the ER-mitochondria interaction.
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- The study investigates the potential causal relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), particularly focusing on ulcerative colitis (UC) and Crohn's disease (CD).
- It uses Mendelian Randomization and genetic variants to analyze the effects of genetically predicted PSC on the risk of developing IBD, identifying a significant link to UC but not to CD.
- The findings highlight a causal association between genetically predicted PSC and UC, while calling for more research to explore shared genetic factors and underlying mechanisms connecting PSC and IBD.
Article Synopsis
- - Traditional Chinese Medicine (TCM) is being investigated for its potential to help with liver issues related to chronic hepatitis B, but its effectiveness on HBsAg seroclearance is still not well understood.
- - In a study, mice were treated with specific TCM granules to see their impact on M1 macrophage polarization and HBsAg levels, and a special TCM formula was developed based on the most effective granules.
- - The findings indicated that the TCM formula improved HBsAg seroclearance, likely by promoting M1 macrophage activity and altering gut microbiota, particularly increasing the presence of Alloprevotella.
Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) is linked to metabolic syndrome, which increases cancer risk, prompting the need for customized cancer screening in high-risk patients.
- The study analyzed data from the Global Burden of Disease 2019 to find that metabolic risks significantly contribute to certain cancers, with age-standardized rates showing higher impacts in older men and individuals with a higher socio-demographic index.
- Results suggest a strong connection between NAFLD and various cancers, advocating for focused cancer screenings for those affected by NAFLD, especially those at greater risk.
Background: Coronavirus disease (COVID-19) patients exhibit different patterns of liver impairment, according to growing evidence.
Aim: In this study, we sought to provide a comprehensive analysis of liver test parameters in patients with severe and non-severe COVID-19.
Methods: We performed a meta-analysis of published liver manifestations and described the liver damage in COVID-19.
Background: To understand the impact of common cancers of the gastrointestinal tract and help to formulate evidence-based policy, we evaluate the relationship between the burden of GI tract cancers and socioeconomics.
Methods: Data on GI tract cancer burden were obtained from the Global Burden of Disease (GBD) 2019 including mortality and incidence rates. According to the Socio-demographic Index (SDI) level, country and territory, and sex, , the data were further stratified.
Background: This study compared clinical features of the Delta variant of coronavirus disease 2019 (COVID-19) in children and adults.
Methods: Clinical data included 80 children and 132 adults with the Delta variant of COVID-19, hospitalized in the Affiliated Hospital of Putian College between September and October 2021. The data was analyzed retrospectively.
Background: Aminoacyl-tRNA synthetases (ARSs) are enzymes responsible for attaching amino acids to tRNA, which enables protein synthesis. Mutations in isoleucyl-tRNA synthetase (IARS1) have recently been reported to be a genetic cause for growth retardation, intellectual disability, muscular hypotonia, and infantile hepatopathy (GRIDHH).
Case Presentation: In this study, we reported an additional case of compound heterozygous missense variations c.
Background And Aims: We aim to develop a diagnostic tool for pathological-image classification using transfer learning that can be applied to diverse tumor types.
Methods: Microscopic images of liver tissue with and without hepatocellular carcinoma (HCC) were used to train and validate the classification framework based on a convolutional neural network. To evaluate the universal classification performance of the artificial intelligence (AI) framework, histological images from colorectal tissue and the breast were collected.
Article Synopsis
- Neocryptolepine derivatives, especially 8-Fluoroneocryptolepine (8FNC), have shown promising cytotoxic effects against gastric cancer, demonstrating greater potency than traditional treatments like cisplatin and fluorouracil.
- 8FNC's effectiveness was enhanced through structural modifications, allowing it to selectively target AGS gastric cancer cells while reducing harm to healthy gastric mucosa cells (GES-1).
- The compound induces apoptosis in AGS cells by disrupting the cell cycle and influencing the PI3K/AKT signaling pathway, indicating its potential as a lead candidate for gastric cancer treatment.
Article Synopsis
- Acute viral hepatitis (AVH) is a significant global health issue, yet research focuses more on chronic infections like HBV and HCV; understanding the burden of AVH is essential for creating global intervention strategies.
- The study analyzed data from the Global Burden of Disease (GBD) 2019 on acute hepatitis A, B, C, and E, revealing high incidence rates in low socio-demographic index (SDI) regions, especially in West and East Africa.
- Findings indicate a correlation between lower socioeconomic status and higher AVH burden, suggesting that policymakers should leverage GBD 2019 data for effective interventions.
Objective: To explore the application of array-based comparative genomic hybridization (a-CGH) technology in the prenatal diagnostic assessment of abnormal serological prenatal screening results of Down's syndrome (DS).
Methods: A total of 3 578 amniotic fluid samples from pregnant women who underwent amniocentesis for prenatal diagnosis solely due to abnormal serological prenatal screening results were selected. The samples were categorized into 3 groups, 2 624 in the high-risk group, 662 in the borderline-risk group, and 292 in the abnormal multiple of median (MoM) group.
Tenofovir and entecavir are currently designated as the preferred oral antiviral drugs for chronic hepatitis B. However, only less than 40% of patients can achieve HBeAg seroconversion. We aim at investigating the role of intestinal microbiome in HBeAg seroconversion induced by oral antiviral therapy and describe multi-omics characteristics of HBeAg seroconversion associated intestinal flora.
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- The study aimed to assess the effectiveness of array-based comparative genomic hybridization (a-CGH) for detecting chromosomal abnormalities in fetuses of older pregnant women.
- Over 3,600 amniotic fluid samples were analyzed, revealing a 2.04% rate of chromosomal aberrations, primarily consisting of aneuploidies and pathogenic copy number variations (CNVs).
- The results indicated that a-CGH is superior to traditional methods in identifying both aneuploidies and pathogenic CNVs, with the detection of aneuploidies increasing with maternal age, but no similar correlation found for pathogenic CNVs.