Publications by authors named "Hong-ling Cheng"
Purpose: To investigate the clinical implications of identifying urothelial carcinoma (UC) with trophoblastic differentiation (UCTD).
Materials And Methods: A prospective cohort study was performed from 2010 to 2016 to examine the incidence of UCTD in urinary tract cancer and association with clinicopathological indicators and patient outcome.
Results: UCTD was detected in 47 of 859 (5.
EMP1, EMP 2, and EMP3 as novel therapeutic targets in human cancer.
Biochim Biophys Acta Rev Cancer
August 2017
The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven members: PMP22, EMP1, EMP2, EMP3, PERP, brain cell membrane protein 1, and MP20. This review addresses the structural and functional features of EMPs, detailing their tissue distribution and functions in the human body, their expression pattern in a variety of tumors, and highlighting the underlying mechanisms involved in carcinogenesis. The implications in cancer biology, patient prognosis prediction, and potential application in disease therapy are discussed.
View Article and Find Full Text PDFPurpose: Mass spectrometry-based biomarker discovery has clinical benefit. To identify novel biomarkers for urothelial carcinoma, we performed quantitative proteomics on pooled urine pairs from patients with and without urothelial carcinoma.
Experimental Design: Shot-gun proteomics using liquid chromatography-tandem mass spectrometry and stable isotope dimethyl labeling identified 219 candidate proteins.
Article Synopsis
- - Hypoxia, a low-oxygen condition in tumors, leads to issues like cancer spread and treatment resistance, but the mechanisms behind cancer adaptation to this stress are unclear.
- - The study discovers that the RON receptor tyrosine kinase moves into the nucleus of cancer cells under hypoxic conditions, where it interacts with HIF-1α and activates the c-JUN promoter, promoting cell survival and growth.
- - The findings highlight RON's novel role as a transcriptional regulator in hypoxia, suggesting that targeting RON with specific inhibitors may offer new treatment strategies for advanced cancer.
[Detection and identification of human metapneumovirus by real time reverse transcription PCR].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
December 2008
Objective: To develop a rapid, sensitive and specific real time reverse transcription PCR for detecting and identifying human metapneumovirus.
Methods: The Hmpv-L gene of human metapneumovirus was chosen as target gene, the primers and TaqMan probe were designed, and the PCR reaction was optimized systematically. The total RNA was extracted from respiratory specimens, and reverse transcription was performed through random primer.