Publications by authors named "Hong-lin Hao"
Article Synopsis
- - This study focused on a large family with multiple neurodegenerative disease symptoms not previously documented, examining the potential genetic causes through physical exams and brain imaging.
- - Researchers found a rare mutation (E795V) in the CARS gene that appeared to correlate with the disease symptoms seen in the affected family members, decreasing aminoacylation activity by 20%.
- - The results provide new insights into the genetic factors contributing to neurodegenerative conditions like Parkinsonism and spinocerebellar ataxia, highlighting a previously unexplored pathway in these diseases.
Objective To explore the clinical characteristics of autoimmune disease with dual seropositive antibodies of leucine-rich glioma inactivated 1(LGI1)and contactin-associated protein 2(Caspr2).Methods The clinical data of seven patients with dual seropositive LGI1 and Caspr2 antibodies who were admitted to the Neurology Department of Peking Union Medical College Hospital from July 2014 to December 2017 were retrospectively analyzed.Results Central,peripheral and autonomic nervous systems were all involved in the seven cases;100%(7/7)presented with insomnia,myokymia,neuropahic pain and hyperhydrosis;71%(5/7)showed memory decline or psychiatric and behavioral symptoms;57%(4/7)had urinary hesitation or constipation;and 43%(3/7)had seizure.
View Article and Find Full Text PDFBackground: Hypertrophic pachymeningitis (HP) is a chronic disease characterized by inflammatory hypertrophy and fibrosis of dura mater. It can be divided into cranial and spinal forms depending on the location of the lesion. HP involving 2 separate sites simultaneously is quite uncommon.
View Article and Find Full Text PDFBackground And Purpose: Some patients with posterior reversible encephalopathy syndrome (PRES) present with atypical clinical and neuroimaging findings. The purpose of this study is to review the clinical and neuroimaging findings in patients diagnosed with PRES.
Methods: We retrospectively included all patients diagnosed with PRES between January 2005 and March 2009.
Objective: To elucidate the clinical and imaging characters of reversible posterior encephalopathy syndrome (PRES) and to discuss the etiological factors and the probable pathogenesis.
Method: Retrospective analysis of basal diseases, clinical manifestations and imaging characters of 13 PRES patients was conducted with follow-ups.
Results: The common associated diseases are various kinds of kidney disease and renal inadequacy, eclampsia of gravidity and postpartum, connective tissue disease and immunosuppressives, et al.