Publications by authors named "Hong-jian Li"
Purpose: To construct a nomogram prediction model on minimal breast cancer (≦ 10 mm) based on clinical and ultrasound parameters.
Methods: Clinical and ultrasound data of 433 patients with minimal breast lesions was conducted in this retrospective study. Patients were randomly divided into a training set and a validation set with a ratio of 7:3.
Unlabelled: To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM.
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- - The study evaluates the effectiveness of an AI-based real-time dynamic ultrasound imaging system for diagnosing small breast lesions (≤10mm) using the BI-RADS classification.
- - In a sample of 291 lesions, the system achieved a high diagnostic accuracy (AUC of 0.833), with better sensitivity using the >BI-RADS 3 threshold compared to >BI-RADS 4A, but lower specificity.
- - The findings suggest that the AI ultrasound system offers promising tools for early breast cancer detection and could enhance patient outcomes, although it still presents some inconsistencies in specific measures.
Article Synopsis
- The study aimed to assess how genetic variations (polymorphisms) in the UGT1A4 and UGT2B7 genes impact the levels of lamotrigine in the blood of Chinese patients with bipolar disorder.
- Researchers analyzed data from 104 patients who had been on a consistent dose of lamotrigine for at least 21 days, measuring plasma concentrations using advanced chromatography techniques.
- Findings revealed that specific genetic profiles (UGT1A4 -142T>G and UGT2B7 -161C>T) significantly influenced lamotrigine levels, with certain genotypes associated with higher concentrations of the drug in the bloodstream.
Article Synopsis
- This study investigates how variations in the CYP3A4 gene affect the levels and effectiveness of the epilepsy drug perampanel (PER) in Chinese children with epilepsy.
- 102 pediatric patients were analyzed after maintaining consistent PER doses for 21 days, measuring drug concentrations and assessing seizure reduction rates.
- The results indicate significant differences in drug concentrations based on genetic variations, with implications for both treatment efficacy and adverse effects, suggesting that CYP3A4 genetic profiles should be considered in prescribing PER.
Purpose: This study aimed to investigate the alteration trends and overlaps of positive features in benign and malignant thyroid nodules of different sizes based on the Chinese Thyroid Imaging Reporting and Data System (C-TIRADS).
Patients And Methods: 1337 patients with 1558 thyroid nodules were retrospectively recruited from November 2021 to December 2023. These nodules were divided into three groups according to maximum diameter: A (≤10 mm), B (10-20 mm), and C (≥20 mm).
Purpose: This study was the first to evaluate the effect of CYP3A5*3 gene polymorphisms on plasma concentration of perampanel (PER) in Chinese pediatric patients with epilepsy.
Methods: We enrolled 98 patients for this investigation. Plasma PER concentrations were measured using liquid chromatography-tandem mass spectrometry.
Purpose: We aimed to investigated the influencing risk factors of voriconazole-induced liver injury in Uygur pediatric patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
Methods: This was a prospective cohort design study. High-performance liquid chromatography-mass spectrometry was employed to monitor voriconazole concentration.
Article Synopsis
- This study investigates the prevalence and genetic diversity of rotavirus group A (RVA) in the Pearl River Delta region of Guangdong, China, focusing on individuals aged 28 days to 85 years.
- Out of 706 stool samples from patients with acute gastroenteritis, 14.59% tested positive for RVA, with co-infections noted in nearly 40% of cases, particularly affecting young children.
- The predominant RVA genotype identified was G9P[8], and findings highlight the need for enhanced surveillance of RVA genetic changes to inform future vaccine development.
The extracellular potassium ion concentration in the brain exerts a significant influence on cellular excitability and intercellular communication. Perturbations in the extracellular potassium ion level are closely correlated with various chronic neuropsychiatric disorders including depression. However, a critical gap persists in performing real-time and long-term monitoring of extracellular potassium ions, which is necessary for comprehensive profiling of chronic neuropsychiatric diseases.
View Article and Find Full Text PDFPotential application of anti-osteoporotic therapy to relieve sarcopenia in the elderly.
Ann Med Surg (Lond)
December 2023
Article Synopsis
- Sarcopenia is a muscle disorder that worsens with aging, particularly in older adults, and currently has no effective drug treatments.
- Osteoporosis, a condition that weakens bones, has various pharmaceutical options available for treatment.
- Recent studies highlight a strong connection between sarcopenia and osteoporosis, suggesting that improving bone health could also help reduce muscle loss.
Background: Information on the efficacy and plasma concentration of perampanel (PER) in Chinese pediatric patients with epilepsy is limited. Therefore, this real-world retrospective study aimed to assess the efficacy, tolerability, and plasma concentration of the maximum dose of PER for epilepsy treatment in Chinese pediatric patients.
Methods: A total of 107 pediatric patients from 2 hospitals in China were enrolled in this study.
The safety and effectiveness of perampanel in clinical settings involving Chinese pediatric patients are limited, as perampanel has only recently been approved for use in China, in September 2019. We aimed to evaluate the efficacy and tolerability of perampanel as an adjunctive therapy for pediatric patients with epilepsy aged ≥ 4 years in Xinjiang, Northwest China. Efficacy was assessed by measuring changes in seizure frequency at 3-, 6-, and 12-month follow-up compared with baseline.
View Article and Find Full Text PDFObjective: P-glycoprotein plays a role in drug resistance of epileptic patients by limiting gastrointestinal absorption and brain access to antiseizure medications. This study aimed to evaluate the association between ABCB1 polymorphisms and drug resistance in epileptic pediatric patients.
Methods: Three hundred seventy-seven epileptic pediatric patients were treated with antiseizure medications and subsequently divided into the drug-responsive group (n = 256, 68%) and drug-resistant group (n = 121, 32%).
Article Synopsis
- A study was conducted to evaluate the effectiveness and tolerability of lacosamide (LCM) in Chinese children and adolescents with refractory epilepsy in Xinjiang, Northwest China.
- Over 105 participants were analyzed, finding responder rates to be 47.6% at 3 months, decreasing to 31.9% by 12 months; seizure freedom rates were 32.4% to 23.6% over the same period.
- The study concluded that LCM is effective and generally well-tolerated, with some patients experiencing treatment-emergent adverse events, highlighting a significant difference in maintenance doses between responders and non-responders.
Article Synopsis
- * A total of 112 pediatric patients received LCM, with 33% starting directly on it and 67% transitioning from other medications; the study tracked their seizure frequency over 12 months.
- * Results showed high responder rates for both treatment groups, with LCM being well-tolerated overall, although there were some adverse reactions (32% for conversion and 40.5% for primary monotherapy).
To evaluate the association between , and polymorphisms and voriconazole plasma concentrations in Uygur pediatric patients with allogeneic hematopoietic stem cell transplantation. High performance liquid chromatography-mass spectrometry was employed to monitor voriconazole concentrations. First-generation sequencing was performed to detect gene polymorphisms.
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- - The study investigated how factors like dose, age, sex, and other medications influence the plasma concentration of lacosamide in Chinese pediatric patients with epilepsy, given that it had not been previously studied in this demographic.
- - Out of 500 patients, 72.2% responded positively to lacosamide treatment, but there was only a weak correlation between the drug dose and its plasma levels; significant factors affecting plasma concentration included age, body mass index, and the use of enzyme-inducing antiseizure medications (EIASMs).
- - The findings suggested that patients on EIASMs had lower plasma concentrations of lacosamide compared to those not on these medications, highlighting the importance of monitoring drug levels to maximize therapy effectiveness and safety
Purpose: We aimed to evaluate the effect of the ABCC2 1249G>A (rs2273697) and -24C>T (rs717620) polymorphisms on lacosamide (LCM) plasma concentrations and the efficacy of LCM in Uygur pediatric patients with epilepsy.
Methods: We analyzed 231 pediatric patients with epilepsy, among which 166 were considered to be LCM responsive. For drug assays, 2-3 mL of venous blood was collected from each patient just before the morning LCM dose was administered (approximately 12 hours after the evening dose, steady-state LCM concentrations).
This study has developed and validated a novel LC-MS/MS assay method to quantify perampanel in pediatric patients with epilepsy in Xinjiang, China. Our assay reduces current specimen volume requirements and decreases the turnaround time for results. Samples were separated by gradient elution and then injected into the mass spectrometer with a total run time of 3 min per sample.
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- The study investigates how variations (polymorphisms) in the ABCB1 gene, which influences drug absorption and efficacy, affect the serum levels of the epilepsy drug lacosamide (LCM) in Uygur children.
- Analysis of 131 Uygur pediatric epilepsy patients revealed that specific genotypes were linked to increased drug resistance and lower concentrations of LCM in the bloodstream.
- The findings suggest that the G2677T/A and C3435T polymorphisms in the ABCB1 gene can impact treatment outcomes, making some patients less responsive to epilepsy medications.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a deadly cancer with few effective treatments, but targeting the CDK4/6 and PI3K/AKT pathways shows promise.
- Researchers identified aminoquinol, an anti-plasmodium drug, as a new multi-kinase inhibitor that significantly reduces cell viability and induces apoptosis in cancer cells.
- In studies, aminoquinol demonstrated strong anti-tumor effects in mice and could be used alone or in combination with other treatments, showing potential as a new therapeutic strategy for HCC.
Purpose: Levetiracetam is approved as an add-on therapy to treat refractory partial seizures in pediatric patients over four years old. The efficacy and safety in pediatric patients with epilepsy in Uygur, China, is unknown. Therefore, the objective of this study was to investigate the safety, efficacy, and tolerability of levetiracetam in pediatric patients with epilepsy in Uygur, China.
View Article and Find Full Text PDFPurpose: Lacosamide (LCM) was approved in China in 2018. However, the safety of LCM has not been established in pediatric patients. Therefore, the objective of this study was to investigate its safety, efficacy, and tolerability in pediatric patients living in Uygur, Northwest China.
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- Cyclin-dependent kinases 2/4/6 (CDK2/4/6) are important for cell cycle progression, and their deregulation is linked to hepatocellular carcinoma (HCC).
- Researchers combined computational and experimental methods to find a triple-inhibitor for CDK2/4/6 from FDA-approved drugs to treat HCC.
- They discovered vanoxerine dihydrochloride as an effective inhibitor, showing significant cytotoxic effects in HCC cell lines and promising anti-tumor activity in mice, suggesting it could be a new treatment option for HCC.