The ion channel activator CyPPA inhibits melanogenesis via the GSK3β/β-catenin pathway.

Research into materials that inhibit melanogenesis in skin has gained interest. Screening for such compounds in B16F10 cells revealed that cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA), a positive modulator of small-conductance Ca-activated K channels, is a strong inhibitor of melanogenesis. We investigated the anti-melanogenic activity of CyPPA and the molecular mechanism by which CyPPA reduced melanin production in normal human melanocytes (NHM).

Histological and molecular analysis of the long-pulse 1,064-nm Nd:YAG laser irradiation on the ultraviolet-damaged skin of hairless mice: In association with pulse duration change.

Background: Nonablative lasers have been widely used to improve photodamaged skin, although the mechanism underlying dermal collagen remodeling remains unclear.

Objective: To investigate the effects and the molecular mechanisms of long-pulse neodymium-doped yttrium aluminum garnet (Nd:YAG) laser irradiation on dermal collagen remodeling in association with different pulse durations.

Material And Methods: Five hairless mice were pretreated with ultraviolet B irradiation for 8 weeks.

Red ginseng extract promotes the hair growth in cultured human hair follicles.

Ginseng has been shown to promote hair growth in several recent studies. However, its effects on human hair follicles and its mechanisms of action have not been sufficiently elucidated. This study aimed to investigate the hair growth-promoting effects of red ginseng extract (RGE) and its ginsenosides.

Synthesis of water well-dispersed PEGylated iron oxide nanoparticles for MR/optical lymph node imaging.

We reported the synthesis of highly water-stable iron oxide nanoparticles by a simple one-pot reaction. Non-toxic polyethylene glycol MW 600 (PEG) acted as a solvent, capping agent and reducing agent in the synthesis of iron oxide nanoparticles. As a result of the synthesis, PEGylated small-size (4.