Publications by authors named "Hong-gui Zhang"
Article Synopsis
- - Yiqi Huoxue Decoction (YQHXD) is a traditional Chinese medicine that treats nephrotic syndrome by promoting blood circulation and relieving edema, but its active ingredients and mechanisms are not fully understood.
- - Researchers utilized Ultra-High Performance Liquid Chromatograph-Mass (UPLC-MS) to identify 233 compounds in YQHXD and 50 that enter the bloodstream, forming a Disease-Drug-Ingredient-Gene (DDIG) network and conducting various pathway analyses.
- - The study found 36 key targets linked to specific signaling pathways, with compounds like Luteolin and Wogonin highlighted as potentially active, ultimately demonstrating that YQHXD can improve renal function and reduce kidney
Ixerin Z, one of major sesquiterpene lactones from Ixeris sonchifolia Hance, was considered to be a major active compound because of their special structure and activity. However, studies on Ixerin Z metabolism have rarely been reported. This study is the first to investigate the in vivo metabolism of Ixerin Z following intravenously administered of Ixerin Z by HPLC-LTQ-Orbitrap mass spectrometry and multiple mass defect filters (MMDF) technique.
View Article and Find Full Text PDFAllergies are highly complex disorders with clinical manifestations ranging from mild oral, gastrointestinal, recurrent wheezing, and cutaneous symptoms to life-threatening systemic conditions. The levels of arachidonic acid, eicosanoids, histamine, organic acids and valine are considered to have a variety of physiological functions in connection with allergies. In this research, we have developed a RP-LC/MS method to separate and quantitate six different potential endogenous biomarkers, including leukotriene B(4) (LTB(4)), prostaglandin D(2) (PGD(2)), arachidonic acid (AA), histamine (HI), lactic acid (LA) and valine (VAL), from serum of rats with ovalbumin (OVA)-induced allergy and normal rats, and the discrepancies between the model group and the control group were compared.
View Article and Find Full Text PDF[Identification of dihydroflavonol glycoside isomers in Smilax glabra by HPLC-MS and HPLC-1H NMR].
Zhongguo Zhong Yao Za Zhi
June 2008
Objective: To identify dihydroflavonol glycoside isomers in Smilax glabra.
Method: The sample was analyzed by HPLC-MS in combination with HPLC-1H-NMR.
Result: Four dihydroflavonol glycoside isomers were identified as astilbin, neoastilbin, isoastilbin, neoisoastilbin.
Aim: To establish a comprehensive HPLC analytical method of Huanglianjiedu decoction.
Methods: This study was performed by HPLC-UV/MS to identify the chemical constituents of the whole and individual herbs of the "Huanglianjiedu decoction". Zorbax Extend C18 (150 mm x 4.
To study the safety of Aconitum medicinal herbs in clinic and identify Aconitum alkaloids poisoning in forensic medicine, Aconitum alkaloids and their metabolites were separated and identified in human urine by liquid chromatography-electrospray ionization-multi-stage mass spectrometry (LC-ESI-MS(n)) and chemical pathway of metabolism was investigated. The alkaloids and their metabolites in the urine sample were extracted with solid-phase cartridges and separated by HPLC with acetonitrile-water-formic acid (40:60:0.5) mobile phase.
View Article and Find Full Text PDFAim: To identify the main metabolites of aconitine in the urine of rabbits.
Methods: After oral administration of aconitine (5 mg.kg-1), the urine of male rabbits was collected and extracted by solid phase extraction and analyzed by liquid chromatography-ion trap mass spectrometry.