Publications by authors named "Hong-guang Han"
[Early and midterm outcomes of artificial chordae transplant in mitral valve repair].
Zhonghua Yi Xue Za Zhi
September 2013
Objective: To summarize the early and midterm outcomes of artificial chordae transplant in mitral valve repair.
Methods: A total of 50 patients underwent mitral valve repair with artificial chordae transplant from January 2009 to January 2010 in General Hospital of Shenyang Military Command. Follow-up was conducted on 48 cases (96%) for 3-4 years.
Several genome-wide association studies on breast cancer have reported similar findings of a new cancer susceptibility locus, 8q24 rsl3281615. Subsequent case-control studies have rapidly investigated the association between the single nucleotide polymorphism of rsl3281615 at chromosome 8q24 and breast cancer risk, but the effect of 8q24 rsl3281615 polymorphism on breast cancer is still unclear due to the inconsistence among those studies. Given the contradictory findings, a meta-analysis was performed to determine the association between 8q24 rsl3281615 polymorphism and breast cancer risk.
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- The study investigates how diazoxide, a mitochondrial ATP-sensitive potassium channel opener, can protect rat hearts from ischaemia-reperfusion injury, potentially through mechanisms similar to ischaemic preconditioning.
- Researchers hypothesize that regulating mitochondrial energetics via the protein PGC-1alpha plays a significant role in this protective effect.
- The experiment involved isolating hearts from Wistar rats, grouping them for different treatments (I/R, IPC, DPC with diazoxide, blank control, and DMSO), and then assessing changes in mitochondrial structure and PGC-1alpha levels through staining and microscopy techniques.
Article Synopsis
- The study investigates the role of nitric oxide (NO) during early myocardial ischemic preconditioning by measuring NO levels, cyclic guanosine monophosphate (cGMP), and nitric oxide synthase (NOS) activity in rats.
- Results show that rats in the ischemic preconditioning group had significantly higher levels of NO and cGMP, and increased NOS activity compared to other groups, suggesting NO's importance in heart protection.
- The findings indicate that fluctuations in NO and cGMP during periods of ischemia and reperfusion point to their potential role as triggers and mediators in myocardial ischemic preconditioning.