[Preparation and drug releasing property of curcumin nanoparticles].

Objective: To prepare curcumin nanoparticles and evaluate the in vitro release of curcumin.

Methods: The chitosan-graft-vinyl acetate copolymers were synthesized by free radical polymerization. Curcumin nanoparticles were synthesized by ultrasonic irradiation.

An efficient and practical synthesis of bis(indolyl)methanes catalyzed by aminosulfonic acid under ultrasound.

Synthesis of bis(indolyl)methanes via electrophilic substitution reactions of indoles with aromatic aldehydes and ketones catalyzed by aminosulfonic acid was carried out in 23-96% yield at 30-38 degrees C in EtOH aqueous solution under ultrasound irradiation.