Clinical characteristics and prognostic characterization of endometrial carcinoma: a comparative analysis of molecular typing protocols.

Background: Endometrial carcinoma (EC) is one of the most common gynecological malignancies in China and globally, accounting for the fourth-prevalent cancer in women. Although numerous studies have confirmed prognostic value of The Cancer Genome Atlas (TCGA) molecular subgroups, it is unclear how they are combined with histological features. The main objective of this study was to compare ProMisE and TCGA classification for the rapid and accurate prediction of prognosis within EC patients, together with the provision of a revised strategy for individualized diagnosis and treatment of patients.

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies.

This study aimed to investigate diabetes distress, happiness, and its associated factors of patients with type 2 diabetes mellitus (T2DM) treated by different therapies, and to analyze the related impact factors. A total of 1512 patients with T2DM were randomly selected from 18 tertiary hospitals in Hunan province from January 2016 to April 2016 who has been treated with oral antidiabetics monotherapy, insulin monotherapy, and combination therapy. Use the general information questionnaire, WHO-5 (the World Health Organization 5 well-being index) and PAID (the problem areas in diabetes scale) to collect the data.

[Clinicopathologic features of combined hepatic carcinoma].

Objective: To investigate clinicopathological features of combined hepatocellular-cholangiocarcinoma (C-HCC-CC) with neuroendocrine carcinoma (NEC) differentiation and to review the literature.

Methods: The clinical data, histological manifestations and immunohistochemical staining results of two cases of C-HCC-CC were analyzed along with a review of the current literature.

Results: Both patients were male with an average age of 57.

[Diagnosis and surgical treatment of solitary fibrous tumor of the pelvis].

Objective: To explore the clinical diagnosis and surgical treatment of pelvic solitary fibrous tumor (SFT).

Methods: The data of nine cases of pelvic solitary fibrous tumor from April 2008 to February 2012 were reviewed retrospectively.

Results: There were 7 male and 2 female patients in this group with a median age of 56 years, of whom 6 were asymptomatic.

[Effect of neoadjuvant chemotherapy on histologic grade and expression of biological markers in breast cancer].

Objective: The aim of this study is to investigate the changes of expression of estrogen receptors (ER), progesterone receptors (PR), Her-2, Ki-67 and histological grade after neoadjuvant chemotherapy in breast cancer.

Methods: Sixty-seven patients with histopathalogically confirmed breast cancer by core needle biopsy received neoadjuvant chemotherapy. The effect of neoadjuvant chemotherapy was assessed according to the criteria of the Japanese Breast Cancer Society: non-effective (G1), mildly effective (G2), moderately effective (G3), markedly effective (G4) and completely effective (G5).

[Differential diagnosis of invasive ductal carcinoma versus invasive lobular carcinoma of breast].

Objective: To study the diagnostic usefulness of immunohistochemical markers in distinguishing between invasive ductal carcinoma and invasive lobular carcinoma of breast.

Methods: Twenty-four cases of grade I invasive ductal carcinoma, 12 cases of classic invasive lobular carcinoma and 14 cases of invasive carcinoma with mixed ductal and lobular features were retrieved from the archival files of Peking University First Hospital during the period from January, 1998 to December, 2001. Immunohistochemical study for E-cadherin, p120 catenin, epithelia membrane protein 1 (EMP1) and DVL1 was performed.

[Spontaneous pregnancy in a patient with lymphocytic hypophysitis].

Lymphocytic hypophysitis(LH) is a rare but increasingly recognized autoimmune endocrine condition that causes partial or total hypopituitarism and is often associated with peripartum young women. We here report a 28-year-old patient who had a spontaneous and uneventful pregnancy following LH that had been treated with transspenoidal surgery and followed by anti-inflammatory agent. The woman failed to lactate and developed frontal headaches 3 months after normal delivery of her first child 3 years ago.

[Expression of proline-rich tyrosine kinase-2 in human primary colorectal carcinoma and its prognostic implication].

Objective: To investigate the expression of proline-rich tyrosine kinase-2 (Pyk2) in human primary colorectal carcinoma (CRC) and it's prognostic significance.

Methods: The expression of Pyk2 was retrospectively examined with immunohistochemistry (IHC) in 108 tissues of primary CRC. The correlation of Pyk2 expression to prognosis and relevant clinical factors were analyzed.

[One patient with Kimura's disease and angiolymphoid hyperplasia with eosinophilia also suffers from kidney injury].

Objective: Reporting a rare case with Kimura's disease and angiolymphoid hyperplasia with eosinophilia (ALHE), who also has nephrotic syndrome resulting from minimal change glomerulopathy.

Methods: Histological manifestations, immunohistochemical staining, immunofluorescence staining, and electron microscope were performed.

Results: One 37-year-old male patient with recurrent erythra, cutaneous node, painless cervical lymph node enlargement and nephrotic syndrome in 5 years.

[Comparative study of heterogeneity of extranodal and nodal diffuse large B cell lymphoma].

Objective: Primary nodal and extranodal diffuse large B-cell lymphoma (DLBCL) were investigated for the heterogeneity of histopathology and immunophenotype, and their relation to clinical stage, comparatively. Whether E2F1 can be used as a germinal center B cell (GCB) DLBCL marker was also discussed.

Methods: Classification of histopathology and immunophenotype of 98 cases were studied by immunohistochemistry in tissue microarray.

[An analysis of the clinical and radiological features of bronchioloalveolar carcinoma].

Objective: To describe the clinical and radiological features of bronchioloalveolar carcinoma.

Methods: Data of 1 050 inpatients of lung cancer, including 50 cases of pathology-proven bronchioloalveolar carcinoma, diagnosed in our hospital between 1993 and 2003, were retrospectively reviewed. The clinical information of all the patients and the HRCT findings of 31 cases of bronchioloalveolar carcinoma were analyzed.

[Helicobacter pylori genotypes of gastrointestinal B cell lymphoma].

Objective: To assess the expression of specific virulence-associated Helicobacter pylori (Hp) genotypes. (cag A, vac A, and ice A status) in primary gastrointestinal B cell lymphoma.

Methods: Forty-nine paraffin wax embedded tissues were analyzed by immunohistochemical staining and polymerase chain reaction.

[Expression of proline-rich tyrosine kinase-2 (Pyk2) in gastric carcinoma and its significance].

Objective: To investigate whether proline-rich tyrosine kinase-2 (Pyk2) is expressed differently in normal gastric mucosas and gastric carcinoma tissues and further to evaluate its significance.

Methods: Expressions of Pyk2 in 59 cases of normal gastric mucosas and 52 cases of gastric carcinoma tissues were analysed by immunohistochemical methods.

Results: Immunohistochemical studies showed that the positive rates of Pyk2 protein expression in normal gastric mucosas and gastric carcinoma tissues were 86.

[Proliferation and apoptosis in primary gastrointestinal B-cell non-Hodgkin s lymphoma and its association with Helicobacter pylori].

Objective: To investigate primary gastrointestinal B-cell non-Hodgkin s lymphoma for clinicopathological features, proliferation, apoptosis and its association with Helicobacter pylori (HP).

Methods: Classification of tumors, expression of HP, proliferation and apoptosis related gene products were studied by immunohistochemistry. Apoptosis was studied by TUNEL (TdT [terminal deoxynucleotidyl transferase] dUTP nick end-labeling).

[Retrospective analysis of 304 cases of malignant lymphomas in pathology: study and practice of the WHO classification of lymphoid neoplasms].

Objective: To evaluate the practical application of the WHO classification of lymphoid neoplasms, and to investigate the relative frequency and geographic distribution of the subtypes of lymphoma.

Methods: The pathological specimens of 304 cases with lymphoma diagnosed during the period 1994 approximately 2002 in the First Hospital of Peking University were retrospectively studied. The histopathologic, immunophenotypic and clinical data were reviewed and reappraisal was performed according to the WHO classification.