Publications by authors named "Hong-cheng Shi"
Article Synopsis
- Researchers developed new insecticides based on the natural compound honokiol, creating novel versions with a specific chemical structure (2-aminobenzoxazole) that were tested against two major agricultural pests.
- The new compounds showed much stronger larvicidal and antifeedant effects than honokiol itself and traditional botanical insecticides.
- Additionally, these compounds demonstrated good effectiveness in greenhouse tests and exhibited moderate toxicity to non-target mammalian cells, indicating potential for safe use in agriculture.*
Article Synopsis
- Two series of vanillin derivatives with 1,3,4-oxadiazole and 1,3-thiazolidin-4-one structures were developed and tested for antifungal effects.
- Some compounds demonstrated strong antifungal activity, with one showing over 42 times more effectiveness than vanillin.
- The cytotoxicity tests indicated that these compounds were selective and less harmful to normal mammalian cells, suggesting a promising therapeutic profile.
Article Synopsis
- The study focuses on creating new agricultural fungicides derived from natural compounds called sesquiterpene lactones, specifically 63 xanthatin-based derivatives with various modifications.
- These derivatives were thoroughly analyzed using advanced techniques like nuclear magnetic resonance and X-ray diffraction to confirm their structures and absolute configurations.
- The antifungal tests revealed that several compounds showed significantly stronger inhibitory effects on fungal spores compared to the original xanthatin and even outperformed a known fungicide, suggesting potential for broad-spectrum fungicidal applications.
Objective: To compare the diagnostic performance of F-FDG PET/MR and PET/CT preliminarily for the thoracic staging of non-small cell lung cancer (NSCLC) with a special focus on pleural invasion evaluation.
Methods: 52 patients with pathologically confirmed NSCLC were included and followed for another year. Whole-body F-FDG PET/CT and subsequent thoracic PET/MR were performed for initial thoracic staging.
Objective: To investigate the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in assessing disease activity in Takayasu arteritis (TA).
Methods: Ninety-one patients with TA were recruited from a Chinese cohort. Clinical data, acute-phase reactants and 18F-FDG-PET/CT findings were simultaneously recorded.
Purpose: The purpose was to investigate the effects of short acquisition time on the image quality and the lesion detectability of oncological F-FDG total-body PET/CT.
Methods: Nineteen oncological patients (6/13 women/men, age 65.6 ± 9.
Article Synopsis
- Hepatocellular carcinoma (HCC) accounts for 85-90% of primary liver cancer cases in China, largely due to widespread chronic hepatitis B infection, making it a major health issue.* -
- The National Health and Family Planning Commission of China released guidelines crafted by over 50 HCC experts, addressing surveillance, diagnosis, staging, and treatment strategies for HCC.* -
- The guidelines include a Chinese staging system and recommendations aimed at optimizing patient outcomes for individuals with HCC in China.*
Objective: Vesicular acetylcholine transporter (VAChT) is a rate-limiting factor for synaptic acetylcholine transport. Our study focused on whether [ F] VAT, a novel positron emission tomography (PET) tracer, could be used in detecting cognitive deficits in epilepsy.
Methods: Morris water maze test was used to evaluate learning and memory deficits in pilocarpine-induced chronic epilepsy rats 12 weeks after status epilepticus.
Article Synopsis
- - The study aimed to compare the image quality, contrast medium volume, and radiation dose between high-pitch and low-pitch renal computed tomography angiography (CTA).
- - Fifty patients were scanned using high-pitch settings with less contrast medium and another fifty with low-pitch settings, finding no significant difference in image quality but a significantly lower radiation dose in the high-pitch group.
- - The results suggest that high-pitch scanning can achieve similar image quality as low-pitch while using less contrast medium and reducing radiation exposure.
Purpose: Osteonecrosis of the femoral head (ONFH) is a very common complication after femoral neck fracture. The purpose of this study was to assess the femoral head vascularity after femoral neck fracture using single photon emission computerized tomography and computerized tomography (SPECT/CT), and to evaluate its value in predicting ONFH.
Methods: Between January 2008 and March 2011, 120 patients diagnosed with femoral neck fracture underwent SPECT-CT before the internal fixation.
Objective: To evaluate the application value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in early diagnosis of lung cancer.
Methods: Retrospective analyses were conducted for 347 cases of pulmonary space-occupying lesions at Zhongshan Hospital from June 2010 to October 2012. The diagnostic validity of PET/CT and fluorodeoxyglucose maximum standardized uptake value (SUVmax) of lesions were compared respectively.
[Hepatocellular carcinoma and angiogenesis imaging using synchrotron radiation].
Zhonghua Gan Zang Bing Za Zhi
September 2013
Objective: To investigate the potential utility of microangiography with synchrotron radiation to detect murine hepatocellular carcinoma (HCC) angiogenesis using an ex vivo model system.
Methods: An HCC xenograft model was established by implanting HCCLM3 cells into male mice livers (n = 6). Twenty-eight days later, three of the mice were randomly selected for barium sulfate infusion into the liver and tumor via the inferior vena cava followed by ligation of the arteries, veins and common bile duct; the remaining three mice were left untreated and served as controls.
Article Synopsis
- The study aims to evaluate blood flow (perfusion) in the femoral head and predict traumatic avascular necrosis (AVN) using SPECT/CT in a model involving adult beagle dogs.
- Eighteen dogs were divided into three groups with varying degrees of blood vessel damage in their femoral heads; SPECT/CT and Laser Doppler Flowmetry (LDF) were used to measure blood supply before and after surgeries.
- Results showed significant blood flow reduction in the most severely treated group (Group C), while SPECT/CT effectively indicated changes in perfusion, suggesting it could help predict AVN development.
Objectives: To compare the efficacy and feasibility between intracoronary and hypodermic injection of granulocyte colony-stimulating factor (G-CSF) on improving cardiac function in a Swine model of chronic myocardial ischemia.
Methods: Eighteen Swine underwent placement of ameroid constrictor on left circumflex coronary artery. The presence of myocardial ischemia was verified at four weeks after the operation, and the animals were then randomly assigned into three groups (n = 6 each): (1) administration of vehicle (control), (2) hypodermic injection of G-CSF (5 microgxkg(-1)x;d(-1)) for five days (IH), and (3) intracoronary injection of a bonus G-CSF (60 microg/kg) (IC).
Objective: To evaluate the myocardial viability with (201)Tl/(18)F-FDG DISA-SPECT technique in patients with acute myocardial infarction underwent emergent intracoronary autologous bone marrow mononuclear cells (BM-MNC) transplantation.
Methods: Patients with first acute myocardial infarction underwent emergent percutaneous coronary intervention (PCI) were randomized in a 1:1 ratio to either intracoronary transplantation of autologous BM-MNC (n = 20) or to sodium chloride concluding heparin (control, n = 20) via a micro infusion catheter group immediately after PCI. Change in global left ventricular function (LVEF measured by echocardiography) and the myocardial viability detected by (201)Tl/(18)F-FDG DISA-SPECT from baseline and 6-months post transplantation were analyzed.