Publications by authors named "Hong-bo Ye"
• Induction of SWEET sugar transporters by bacterial pathogens via transcription activator-like (TAL) effectors is necessary for successful blight infection of rice, cassava and cotton, - likely providing sugars for bacterial propagation. • Here, we show that infection of by the necrotrophic fungus causes increased accumulation of amino acid transporter UmamiT20 mRNA in leaves. UmamiT20 protein accumulates in leaf veins surrounding the lesions after infection.
View Article and Find Full Text PDFTwo new phenols, ardisiphenol I () and ardisiphenol J (), along with three known compounds () were isolated and identified from the roots of var. bicolor. Their structures were elucidated by means of spectroscopic techniques.
View Article and Find Full Text PDFStroke is a multiphasic process in which initial cerebral ischemia is followed by secondary injury from immune responses to ischemic brain components. Here we demonstrate that peripheral CD11bCD45 myeloid cells magnify stroke injury via activation of triggering receptor expressed on myeloid cells 1 (TREM1), an amplifier of proinflammatory innate immune responses. TREM1 was induced within hours after stroke peripherally in CD11bCD45 cells trafficking to ischemic brain.
View Article and Find Full Text PDFHigh blood sugar is a symptom of diabetes mellitus (DM). Vascular endothelial cells (VECs) directly contact the blood and are damaged when blood sugar levels are high. However, the molecular mechanism underlying this process remains elusive.
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- - The study investigates the role of the Qc-SNARE protein AtBS14b in the brassinosteroid (BR) signaling pathway in Arabidopsis, focusing on its effects on plant morphology and BR responsiveness.
- - Overexpressing AtBS14b led to shorter hypocotyls and petioles, and reduced sensitivity to BR, while AtBS14b mutants showed no significant morphological changes related to BR signaling.
- - AtBS14b was found to directly interact with the membrane steroid binding protein 1 (MSBP1), suggesting its unique function in modulating BR responses in plants, marking it as the first SNARE protein known to interact with MSBP1.
Article Synopsis
- Delayed wound healing is a key symptom of diabetes mellitus (DM), affecting many patients globally, and the study investigates how high glucose (HG) conditions impact fibroblast cell migration.
- Findings show that while 30 mM HG impedes cell migration, it does not hinder cell proliferation, and bFGF can partially restore normal migration rates by promoting cell movement.
- Mechanistically, the research reveals that HG increases reactive oxygen species (ROS) production and represses JNK phosphorylation, which is crucial for bFGF-regulated migration, demonstrating a link between HG-induced migration delay and bFGF signaling suppression.
Objective: A multicenter population pharmacokinetics study of propofol was performed to establish a new population model.
Materials And Methods: Three thousand two hundred and fifty-nine blood samples of 220 participants were measured by HPLC-UV or HPLC-FLU or GC-MS. Target-controlled infusion after single bolus or continuous infusion was applied for propofol anesthesia.
Article Synopsis
- A three-compartment population pharmacokinetic model was developed to predict the concentration of intravenously administered propofol using data from five hospitals and analyzed through the NONMEM software.
- The analysis looked at how factors such as body weight, age, and gender influenced key pharmacokinetic parameters (like clearance and volume distribution) using various models to account for individual variability.
- The final model demonstrated good predictive ability, with a high determination coefficient (0.91) and stability through methods like Bootstrapping, showing that body weight positively affects clearance and highlights differences in pharmacokinetics between genders and ages.