Efficacy and safety of EGFR-TKIs in combination with angiogenesis inhibitors as first-line therapy for advanced EGFR-mutant non-small-cell lung cancer: a systematic review and meta-analysis.

Background: For patients with advanced non-small-cell lung cancer (NSCLC) with EGFR mutations, the suggested course of action is epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Even with a high disease control rate, a majority of patients develop acquired EGFR-TKIs resistance and eventually advance. To increase the benefits of treatment, clinical trials are increasingly exploring the value of EGFR-TKIs combined with angiogenesis inhibitors as a first-line treatment in advanced NSCLC carrying EGFR mutations.

Global trends in polycystic ovary syndrome research: A 10-year bibliometric analysis.

Background: Polycystic ovary syndrome (PCOS) is one of the most common reproductive metabolic disorders in women, significantly affecting the biological functionalities of ovaries. This disease has garnered enormous interest from researchers. However, there is a lack of a comprehensive research concerning assessing the current status and future trends in PCOS field.

Design, synthesis, and biological evaluation of benzo[b]thiophene 1,1-dioxide derivatives as potent STAT3 inhibitors.

As a member of the signal transducer and activator of transcription (STAT) family, STAT3 plays a critical role in several biological pathways such as cell proliferation, migration, survival, and differentiation. Due to abnormal continuous activation in tumors, inhibition of STAT3 has emerged as an attractive approach for the treatment of various cancer cells. Herein, we report a series of novel STAT3 inhibitors based on benzo[b]thiophene 1,1-dioxide scaffold and evaluated their anticancer potency.

Untargeted metabolomics approach (UPLC-Q-TOF-MS) explores the biomarkers of serum and urine in overweight/obese young men.

Background And Objectives: Obesity is linked to metabolic diseases characterized by insulin resistance, such as diabetes and cardiovascular disease. In this study, we investigated the metabolic disorders of uncomplicated obesity to identify early alterations in biological systems.

Methods And Study Design: Metabolic differences between overweight/obese (n=36) and normal-weight (n=35) young Chinese men without known metabolic disorders were assessed.

The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory.

Objective: To gain a better understanding of gene expression changes in the brain following microwave exposure in mice. This study hopes to reveal mechanisms contributing to microwave-induced learning and memory dysfunction.

Methods: Mice were exposed to whole body 2100 MHz microwaves with specific absorption rates (SARs) of 0.

Dynamic changes of early-stage aortic lipid deposition in chronic renal failure rats and effects of decorin gene therapy.

The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into control and experimental groups. Sprague Dawley rats receiving 5/6 nephrectomy were divided into control and experimental groups, and the experimental group was further subdivided into rats receiving treatment with fibroblasts (FBs) transfected either with empty vector and with a decorin (DCN) gene.

[Effects of long-term fertilization on pH buffer system of sandy loam calcareous fluvor-aquic soil].

Soil samples (0-80 cm) were collected from a 30-year fertilization experimental site in Xuzhou, Jiangsu Province of East China to study the variations of the pH, calcium carbonate and active calcium carbonate contents, and pH buffer capacity of sandy loam calcareous fluvor-aquic soil under different fertilization treatments. Thirty-year continuous application of different fertilizers accelerated the acidification of topsoil (0-20 cm), with the soil pH decreased by 0.41-0.

Bis{2-[2-(isopropyl-ammonio)ethyl-imino-meth-yl]-6-methoxy-phenolato}nickel(II) dithio-cyanate.

The title complex, [Ni(C(13)H(20)N(2)O(2))(2)](NCS)(2), consists of a centrosymmetric mononuclear four-coordinate nickel(II) complex cation and two thio-cyanate anions. The Ni atom is located on an inversion center and is coordinated by two phenol O atoms and two imine N atoms from two equivalent Schiff base ligands, in a square-planar geometry. In the crystal structure, the amino H atoms are involved in N-H⋯O hydrogen bonds with the phenol and meth-oxy O atoms of the ligand, and in N-H⋯N hydrogen bonds with the N atoms of the thio-cyanate anions, which sit above and below the Ni atom.

3,4-Dihydr-oxy-N'-(2-hydroxy-benzyl-idene)benzohydrazide-methanol-water (2/1/3).

The asymmetric unit of the title compound, C(14)H(12)N(2)O(4)·0.5CH(4)O·1.5H(2)O, consists of two Schiff base mol-ecules, three water mol-ecules and one methanol mol-ecule.

[Effects of 2450 MHz microwave on long-term potentiation of hippocampus and lipofuscin contents in rat brain].

Objective: To study the mechanism of the effects of microwave on learning and memory.

Method: Long-term potentiation (LTP) of hippocampus induced potential and lipofuscin content in rat brain were studied. After irradiated by a 2450 MHz microwave, rats hippocampus induced potential in vivo was recorded and lipofuscin content in the brain was measured by fluorospectrophotometry.

Combined human growth hormone and lactulose for prevention and treatment of multiple organ dysfunction in patients with severe chronic hepatitis B.

Aim: To evaluate the efficiency and safety of combined recombinant human growth hormone (rhGH) and lactulose for treatment and/or prevention of multiple organ dysfunction in patients with chronic severe hepatitis B.

Methods: Forty-eight inpatients with chronic severe hepatitis B were randomly divided into rhGH group (n=28) and control group (n=20). In rhGH group, 4-4.

[Effects of microwave irradiation on ATPase activity and voltage dependent ion channel of rat hippocampus cell membrane].

Objective: To study the effect of microwave irradiation on hippocampus cell.

Method: Changes of ATPase activity and voltage dependent ion channel of hippocampus cell membrane were observed in mice exposed to 2 450 MHz microwave irradiation of 10 mW/cm2 from a physical therapy machine. Histochemical method and patch clamp method were used to determine the activity of Na+, K(+)-ATPase, Ca2+, Mg(2+)-ATPase and voltage dependent Na+, K+, Ca2+ channels respectively.