Publications by authors named "Hong-Zhi Cao"
We present the application of -difluoroacetylglucosamine (GlcNDFA) in a chemical evolution strategy to synthesize oligosaccharides. In comparison to conventional -trifluoroacetylglucosamine, GlcNDFA exhibits superior substrate compatibility with glycosyltransferases as well as stability in aqueous environments. Using our 16-step assembly line, GlcNDFA can be used to produce homogeneous dekaparin, a heparin-like medication, with a yield of 62.
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- * The virus tends to integrate into fragile areas and specific functional regions like CpG islands, with different patterns observed between tumor and non-tumor tissues, particularly near telomeres in tumors.
- * Males show a higher frequency of HBV integration than females, especially on chromosome 17, and distinct patterns are influenced by the presence of cirrhosis, indicating that HBV integration can significantly contribute to the development of cancer.