Publications by authors named "Hong-Zhen Xia"
Article Synopsis
- The study aimed to explore the relationship between genetic variants (SNPs) in the osteopontin (OPN) and CD44 genes and their influence on gastric cancer risk and expression.
- Researchers analyzed 26 SNPs in gastric cancer patients from the Chinese Han population, employing advanced techniques like Sequenom and immunohistochemistry on tissue samples.
- Findings indicated that specific SNPs in OPN were linked to reduced gastric cancer risk, while other variants in OPN and CD44 were associated with increased cancer susceptibility, revealing correlations between genetic markers, OPN/CD44 expression, and patient clinical features like tumor staging and metastasis.
Article Synopsis
- The study aimed to explore the link between genetic variations (specifically SNPs) in a cluster of genes on chromosome 17q12-q21 and the risk of gastric cancer in the Chinese Han population.
- No significant associations were found between SNPs and gastric cancer risk, but a specific haplotype (CCCT) related to the STARD3 gene appeared to offer some protective effect against the disease.
- Additionally, the study found that STARD3 expression in gastric tissues correlated with various factors such as gender and alcohol consumption, suggesting it might play a role in the development of gastric cancer among the subjects studied.
Article Synopsis
- The study examines how specific genetic variations (SNPs) in the adiponectin (ADIPOQ), adiponectin receptor 1 (ADIPOR1), and adiponectin receptor 2 (ADIPOR2) genes are linked to the risk and progression of gastric cancer among the Chinese Han population.
- Certain SNPs were found to have significant associations with either decreased risk of cardia cancer or increased risk of body cancer, indicating that these genetic markers could influence tumor location and aggressiveness.
- Additionally, the research showed correlations between adiponectin expression and factors like gender, alcohol consumption, family history, and tumor characteristics, suggesting that these genes may act as indicators of susceptibility
Host immune responses are critical steps for carcinogenesis. Single nucleotide polymorphisms (SNPs) in immunoregulatory genes may influence gastric cancer risk. We performed a genotyping analysis for immunoregulatory genes in 311 gastric cancer cases and 425 controls from a Chinese population.
View Article and Find Full Text PDF