Publications by authors named "Hong-Yuan Li"
Evaluating the risk factors for the conversion from robotic-assisted partial nephrectomy (RAPN) to radical nephrectomy (RN). Through a comprehensive database search encompassing PubMed, Web of Science, Embase, and the Cochrane Library, we identified pertinent English-language research published by June 2024. We utilized the NOS scale for quality assessment.
View Article and Find Full Text PDFPurpose: This research aims to use a data-driven analytical method to compare the effectiveness of High-Intensity Focused Ultrasound (HIFU) partial gland ablation with Robot-Assisted Radical Prostatectomy (RARP) for treating localized prostate cancer, evaluating variations in treatment results.
Methods: We performed a systematic review of the literature, covering key databases including the Cochrane Library, PubMed, EMBASE, Web of Science, and Google Scholar, with the latest information updated until August 2024. We utilized Stata 18 for data analysis, computing weighted mean differences (WMDs) for continuous data and odds ratios (ORs) for categorical data, with all results reported alongside 95% confidence intervals (CIs).
Article Synopsis
- Pulmonary nocardiosis (PN) is a rare opportunistic infection studied in southern China, focusing on clinical, radiological, and microbiological aspects along with treatment outcomes.
- The research included 67 PN patients, revealing that bronchiectasis was the most common respiratory condition, with cough and sputum as the major symptoms, while Nocardia farcinica was identified as the most prevalent pathogen.
- Factors linked to poor prognosis included a higher neutrophil-to-lymphocyte ratio, concurrent bacterial infections, and the use of carbapenems.
Article Synopsis
- This study compared two types of surgery for prostate cancer: robotic-assisted radical prostatectomy (RARP) and three-dimensional laparoscopic radical prostatectomy (3D LRP) by reviewing many medical studies.
- RARP led to much less blood loss during surgery, but both surgery types had similar results in terms of recovery time and other health checks afterward.
- The overall conclusion is that RARP is better for blood loss, but both surgeries are mostly the same when looking at other important outcomes.
Objective: The influence of robot-assisted radical prostatectomy (RARP) in obese (OB) and non-obese (NOB) prostate cancer patients remains a topic of debate. The objective of this study was to juxtapose the perioperative, functional, and oncologic outcomes of RARP in OB and NOB cohorts.
Materials And Methods: We systematically searched the databases such as PubMed, Embase, Web of Science, and the Cochrane Library database to identify relevant studies published in English up to September 2023.
Article Synopsis
- The study evaluates the effects of adjuvant chemotherapy on survival outcomes in patients with lymph node-positive and locally advanced bladder cancer after surgery.
- A total of 21 studies involving 12,888 patients were analyzed, revealing that those who received adjuvant chemotherapy had significantly better overall and recurrence-free survival compared to those who only had surgery.
- The findings suggest that patients who undergo cisplatin-based chemotherapy experience better outcomes than those on carboplatin or other regimens, with lymph node density identified as a key predictor for overall survival.
This study aims to compare the perioperative, oncological, and functional outcomes of perineal hydrodissection (HD) with standard treatment (ST) in patients undergoing robot-assisted radical prostatectomy. We performed an exhaustive search in databases such as PubMed, Embase, Web of Science, and the Cochrane Library, seeking English-language studies relevant to our research question, with a cutoff date of April 2024. The pooled results were assessed using the weighted mean differences (WMDs), standardized mean differences (SMDs), and odds ratios (ORs) metrics.
View Article and Find Full Text PDFThe purpose of this study was to conduct a comparative analysis of the perioperative outcomes associated with robot-assisted laparoscopic prostatectomy (RARP) versus open radical prostatectomy (ORP) in the obese population diagnosed with prostate cancer. We performed a comprehensive search in key databases such as PubMed, Embase, Web of Science, and the Cochrane Library, encompassing studies of all languages, with a final search date of April 2024. We also omitted articles that consisted of conference abstracts and content that was not pertinent to our study.
View Article and Find Full Text PDFArticle Synopsis
- The study compares the effectiveness of cold knife versus laser incisions for treating urethral strictures by analyzing factors like urinary flow rates, surgical time, and recurrence rates over a year.
- Researchers examined literature from multiple databases, including data from 659 participants across nine experiments, and used Stata for their analysis.
- Results indicated that laser treatment produced better outcomes than the cold knife method in long-term urinary flow and reduced bleeding, suggesting laser urethral incision might be a superior option for patients with urethral strictures under 2 cm.
Objective: This study aimed to explore possible associations between molecular subtypes and site of distant metastasis in advanced breast cancer (ABC).
Methods: 3577 ABC patients were selected from 21 hospitals of seven geographic regions in China from 2012-2014. A questionnaire was designed to collect medical information regarding demographic characteristics, risk factors, molecular subtype, recurrence/metastasis information, and disease-free survival (DFS).
Background: Several studies have indicated possible associations between age and the prognosis of breast cancer (BC), but limited data are available from hospital-based multicenter studies in China. This study aimed to explore the associations between age at initial diagnosis of BC and the risk of recurrence or metastasis among Chinese women with newly diagnosed advanced breast cancer (ABC) and provide treatment decision support for BC patients of different ages to medical workers.
Methods: The medical records of patients newly diagnosed with ABC were obtained from 21 hospitals in seven geographic regions in China from 2012 to 2014.
Quorum sensing (QS) plays an essential role in virulence factor production, biofilm formation, and antimicrobial resistance. As a potent QS inhibitor, hordenine can inhibit both QS and biofilm formation in and . In this work, we tested the QS inhibitory potential of 27 hordenine analogs against QS and biofilm formation in and Among the tested analogs, seven (12, 28, 27, 26, 2, 23, and 7) exhibited strong QS inhibitory activity against , five of which (12, 28, 27, 26, and 2) showed better inhibitory activity than hordenine.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the effects of surgery on breast cancer (BC) patients who only had bone metastases using data from the SEER database.
- It found that patients who underwent surgery had longer median survival times compared to those who didn't, with breast-conserving surgery showing the most significant improvement in survival.
- The conclusion suggests that primary surgery, especially when tumor burden is low, can enhance the survival of BC patients with bone metastasis, making breast-conserving surgery a preferable option.
Objective: To better understand the status of medical treatment for human epidermal growth factor receptor 2 (HER2)-positive breast cancer and the differences between the Chinese and the international clinical practice.
Methods: This was a retrospective, nationwide, multicenter, epidemiological study of advanced breast cancer patients from China. Between January 01, 2012, and December 31, 2014, a total of 3649 patients, covering 7 geographic regions and 21 institutions, participated in this series of studies.
Inflammation-modulating nutrients and inflammatory markers are established cancer risk factors, however, evidence regarding the association between post-diagnosis diet-associated inflammation and breast cancer survival is relatively sparse. We aimed to examine the association between post-diagnosis dietary inflammatory index (DII®) and risks of all-cause and breast cancer-specific mortality. A total of 1064 female breast cancer survivors in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) Trial prospective cohort, were included in this analysis if they had completed the diet history questionnaire (DHQ).
View Article and Find Full Text PDFAlthough receptor status including estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) of the primary breast tumors was related to the prognosis of breast cancer patients, little information is yet available on whether patient management and survival are impacted by receptor conversion in breast cancer metastases. Using data from the nation-wide multicenter clinical epidemiology study of advanced breast cancer in China (NCT03047889), we report the situation of retesting ER, PR and HER2 status for breast cancer metastases and evaluate the patient management and prognostic value of receptor conversion. In total, 3295 patients were analyzed and 1583 (48.
View Article and Find Full Text PDFObjective: Secondary hyperparathyroidism (SHPT) is a common complication of end-stage renal disease (ESRD), and part of SHPT patients need receive parathyroidectomy (PTX). However, as an important postoperative complication of SHPT, thyrotoxicosis has received little attention. Therefore, in this article, we aimed to study the status of transient thyrotoxicosis after PTX for SHPT patients with ESRD and normal thyroid function.
View Article and Find Full Text PDFPurpose: Chemotherapy-related cognitive impairments in breast cancer patients were usually reported through cognitive questionnaires or scales which may be subjective and insensitive. This study is to assess the effect of chemotherapy on cognitive function in breast cancer patients stratified by age using objective electrophysiological measure, the P300 component of event-related potentials (ERPs) with a large sample size.
Methods: Totally, 529 primary breast cancer patients, including 178 cases at initial diagnosis stage and before chemotherapy (Group1), 167 cases during chemotherapy (Group2), and 184 cases post chemotherapy and during follow-up period (Group3), were examined with ERPs (P300 component) to assess the effect of chemotherapy on their cognitive function.
Clinicopathologic and Prognostic Significance of Body Mass Index (BMI) among Breast Cancer Patients in Western China: A Retrospective Multicenter Cohort Based on Western China Clinical Cooperation Group (WCCCG).
Biomed Res Int
November 2019
Article Synopsis
Introduction: Role of surgery in the management of de novo stage IV breast cancer (BC) remains controversial. We aimed to determine the survival benefit of primary surgery on the basis of metastatic pattern.
Materials And Methods: A retrospective cohort study based on the SEER database was conducted to identify patients with de novo stage IV BC diagnosed between 2010 and 2015.
Purpose: Accumulating evidence indicated that triple-negative breast cancer (TNBC) can stimulate stronger immune responses than other subtypes of breast cancer. We hypothesized that integrating immune-related genomic signatures with clinicopathologic factors may yield a predictive accuracy exceeding that of the currently available system.
Methods: Ten signatures that reflect specific immunogenic or immune microenvironmental features of TNBC were identified and re-analyzed using bioinformatic methods.
To analyze whether neoadjuvant chemotherapy (NAC) changes the expression rates of invasive ductal carcinoma (IDC) markers: estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki67, and P53.This was a retrospective study of 112 IDC patients who underwent NAC (docetaxel+epirubicin/pirarubicin+cyclophosphamide) but without pathological complete response (pCR) in 2012 to 2013 at the First Affiliated Hospital of Chongqing Medical University. The IDC subtypes and tumor protein markers were analyzed by immunohistochemistry (IHC).
View Article and Find Full Text PDFBackground: The role of histology subtype on the prognosis of T1-2 breast cancer patients receiving breast-conserving surgery (BCS) is not clear.
Methods: The Surveillance, Epidemiology, and End Results (SEER) Program was used to compare overall survival, second primary cancer-free survival (CFS), and local recurrence risk (LR) for patients with invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC), both receiving BCS.
Results: The study enrolled 196,688 patients with T1-2 disease receiving BCS, including 12,906 with ILC and 183,782 with IDC.
Article Synopsis
- The study investigates the impact of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk and mortality in women with BRCA mutations through a meta-analysis of existing literature.
- Results indicate that RRSO significantly lowers breast cancer incidence in women with BRCA1/2 mutations without a prior history of cancer, and also reduces recurrence risk in those with a history.
- The findings suggest that while RRSO is associated with improved survival rates, more recent studies show inconsistent results regarding its effectiveness in reducing breast cancer risk, highlighting the importance of publication year in these assessments.