Publications by authors named "Hong-Yu Ji"

The tribe Collabieae (Epidendroideae, Orchidaceae) comprises approximately 500 species. Generic delimitation within Collabieae are confusing and phylogenetic interrelationships within the Collabieae have not been well resolved. Plastid genomes and nuclear internal transcribed spacer (ITS) sequences were used to estimate the phylogenetic relationships, ancestral ranges, and diversification rates of Collabieae.

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FAM50A encodes a nuclear protein involved in mRNA processing; however, its role in cancer development remains unclear. Herein, we conducted an integrative pan-cancer analysis using The Cancer Genome Atlas, Genotype-Tissue Expression, and the Clinical Proteomic Tumor Analysis Consortium databases. Based on the gene expression data from TCGA and GTEx databases, we compared FAM50A mRNA levels in 33 types of human cancer tissues to those in corresponding normal tissues and found that FAM50A mRNA level was upregulated in 20 of the 33 types of common cancer tissues.

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Elevated serum uric acid (SUA) levels are associated with coronary artery disease (CAD). However, whether this association is independent of traditional cardiovascular risk factors remains controversial. Our study aimed to determine the concentration of SUA in the presence and severity of CAD in multi-ethnic patients in Xinjiang, China.

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Background: Pathological cardiac hypertrophy is a compensated response to various stimuli and is considered a key risk factor for heart failure. 7,8-Dihydroxyflavone (7,8-DHF) is a flavonoid derivative that acts as a small-molecule brain-derived neurotrophic factor mimetic. The present study aimed to explore the potential role of 7,8-DHF in cardiac hypertrophy.

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Brain-derived neurotrophic factor (BDNF)/tyrosine kinase receptor B (TrkB) pathway is a therapeutic target in cardiac diseases. A BDNF mimetic, 7,8-dihydroxyflavone (7,8-DHF), is emerging as a protective agent in cardiomyocytes; however, its potential role in cardiac fibroblasts (CFs) and fibrosis remains unknown. Thus, we aimed to explore the effects of 7,8-DHF on cardiac fibrosis and the possible mechanisms.

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Article Synopsis
  • The Orchidaceae family, particularly Phaius flavus, faces significant threats due to habitat loss and low germination rates, leading to a decline in their populations.
  • Research involved creating detailed life and fertility tables, along with survival and mortality curves, which showed declining trends in populations from Wuhu Mount and Luohan Mount, and a stable but vulnerable population from Beikengding Mount.
  • To help conserve P. flavus, it is recommended to restrict human activities in their habitats and implement ex situ conservation efforts, such as botanical gardens, to prevent further decline.
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Article Synopsis
  • - The study focused on creating and characterizing a monoclonal antibody (mAb) specifically targeting human carboxylesterases-II (hCE-II) using a hybridoma technique with BALB/c mice immunized with human liver microsome protein.
  • - A successful clone producing the mAb was identified, classified as IgG1(kappa), and demonstrated a high specificity for hCE-II through various methods, including ELISA and Western blot analysis, confirming its weight of 62,000 Daltons.
  • - The findings suggest that this newly developed mAb could be valuable for future research on hCE-II functions and potentially aid in the diagnosis and treatment of liver cancer.
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This study investigated the role of 15-hydroxyeicosatetraenoic acid (15-HETE) in rabbit pulmonary arterial smooth muscle cells (PASMCs) under hypoxia by using organ bath and whole cell patch-clamp techniques. Neonatal rabbits born into normoxic environment were transferred after first feeding into normal and hypoxic environments with respectively 0.21 and 0.

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Aim: To prepare solid lipid nanoparticles by microemulsion technique.

Methods: Stearic acid was used as the oil phase, lecithin as surfactant, alcohol as cosurfactant and distilled water as the aqueous phase. Microemulsion was prepared by mixing the above component in proper ratio.

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