Platelet-secreted CCL3 and its receptor CCR5 promote invasive and migratory abilities of anaplastic thyroid carcinoma cells via MMP-1.

Platelet counts have been reported to be closely related to distant metastasis of many malignant tumors. Our previous study showed that elevated peripheral blood platelet counts may be an adverse prognostic factor of anaplastic thyroid carcinoma (ATC) patients, indicating that platelets may promote ATC progression. In the present study, we aimed to identify the role of platelets in ATC cell invasion and migration and to explore the underlying mechanisms.

Bafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy.

The role of autophagy in tongue squamous cell carcinoma (TSCC) cisplatin resistance is unclear. We aimed to identify a possible synergistic effect of autophagy inhibitors and cisplatin in TSCC cells and explore the underlying mechanism. Our results indicate that autophagic flux was high in TSCC cells; Autophagy inhibitor bafilomycin A1 increased cisplatin cytotoxicity in TSCC cells by inhibiting lysosomal uptake of platinum and enhancing intracellular platinum ion binding to DNA; Autophagy gene (Atg5) knockout in TSCC cells did not duplicate the above-mentioned sensitization of bafilomycin A1.

Bis(nitrato-κO)(5,7,12,14-tetra-methyl-1,4,8,11-tetra-aza-cyclo-tetra-decane-6,13-diaminium-κN,N,N,N)copper(II) dinitrate tetra-hydrate.

In the title compound, [Cu(NO(3))(2)(C(14)H(36)N(6))](NO(3))(2)·4H(2)O, the Cu(II) atom, lying on an inversion center, is six-coordinated in a distorted octa-hedral environment by four N atoms from a centrosymmetric 14-membered tetra-aza-cyclo-tetra-decane macrocyclic ligand and two O atoms from two nitrate anions. The supra-molecular network is consolidated by extensive O-H⋯O and N-H⋯O hydrogen-bonding inter-actions.