Significant positive correlation of plasma BPDE-albumin adducts to urinary 1-hydroxypyrene in coke oven workers.

Objective: To investigate the application of BPDE-albumin adducts as monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) and to explore possible relationship between BPDE-albumin adducts and urinary 1-hydroxypyrene (1-OHP) levels in them.

Methods: Thirty-seven coke oven workers from a coke plant and 47 controls without the occupational exposure to PAHs were recruited in this study. The levels of plasma BPDE-albumin adducts and urinary 1-OHP were analyzed using high performance liquid chromatography.

[Prognostic significance of lymph node micrometastasis in colorectal cancer].

Background & Objective: There have been many controversies about the prognostic significance of lymph node micrometastasis. The aim of this study was to characterize the prognostic significance of lymph node micrometastasis of colorectal cancer.

Methods: Specimens of curative resection between 1988 and 2001 were collected from The Affiliated Hospital of Jianghan University Medical and Life Science College.