Publications by authors named "Hong-Xue Wu"
Article Synopsis
- * Researchers analyzed data from 1408 patients and identified key prognostic factors such as tumor grade, size, and nutritional index, forming the basis for the GATIS score.
- * The GATIS score demonstrated better predictive accuracy for patient outcomes compared to traditional methods like TNM staging and WHO grading, indicating it could significantly enhance prognosis evaluation for R-NENs.
Objectives: To explore HtrA1 gene expression and its regulation in human gastric cancers.
Methods: The HtrA1 mRNA levels were examined by QPCR analysis and confirmed its expression with Northern blot analysis. The HtrA1 protein levels in all six gastric epithelial cell lines were investigated by Western blot analysis.
Ubiquitin-specific protease 10 (USP10), a novel deubiquitinating enzyme, had been associated with growth of tumor cell. However, the role of USP10 in gastric cancer carcinogenesis had not been elucidated yet. The aim of this study was to investigate the expression level of USP10 in gastric carcinoma (GC) tissues and cell lines, then to evaluate the clinical significance of USP10 in GC patients.
View Article and Find Full Text PDFBackground/aims: We investigated effects of CED-3 and CED-4-siRNA on prolonging dendritic cell life in vivo and in vitro.
Methodology: The DCs were divided into three groups: pure-DC, siRNA and CED-3 and CED-4-siRNA. we performed anti-apoptosis assays for DCs with flow cytometry.
Aim: To evaluate the effects of adenovirus-mediated gene transfer of RhoA siRNA and RhoC siRNA on proliferation and invasion of SGC7901 cells by Rho/PI3K/Akt pathway.
Methods: Plasmid of RhoA siRNA and RhoC siRNA were constructed and transfected into SGC7901 cells. siRNA and LY294002 (PI3K inhibitor) were designed as the control group.