Publications by authors named "Hong-Wu Liu"

Article Synopsis
  • Bacterial biofilm acts like a protective fortress for bacteria, making it tough for drugs and pesticides to work against them.
  • Scientists are using a method called photopharmacology, which means using light to control how certain molecules behave, to develop new drugs that can tackle these biofilms.
  • They created a special molecule called A11 that can effectively fight against biofilms, and its strength improves even more when exposed to UV light, making it a promising option for future treatments!
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Nowadays, reactive oxygen species (ROS) have been acknowledged as promising bactericidal targets against pesticide-resistant bacteria. Herein, to further excavate more excellent ROS inducers, simple 1,2,3,4-tetrahydro-β-carboline derivatives containing a 3-aminopropanamide moiety were prepared and assessed for their antibacterial potency. Notably, three promising compounds displayed significant antibacterial potency.

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Article Synopsis
  • Scientists are studying new chemicals called cinnamic acid derivatives to help fight plant diseases caused by viruses and bacteria.
  • One of these chemicals, called compound A, was found to work really well against a virus that affects tobacco plants, offering better protection than some existing treatments.
  • The research shows that compound A might help plants get stronger against these diseases by boosting their natural defenses, which could lead to better crop yields in the future.
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Discovering new anti-virulent agents to control plant bacterial diseases by preventing bacterial pathogenesis/pathogenicity rather than affecting bacterial growth is a sensible strategy. However, the effects of compound-manipulated bacterial virulence factors on host response are still not clear. In this work, 35 new 1,3,4-oxadiazole derivatives were synthesized and systematically evaluated for their anti-phytopathogenic activities.

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Background: Gradually aggravated disease caused by phytopathogenic bacteria severely restricts food security and crop yield, and few pesticides can relieve this severe situation. Thus, development and excavation of new agrochemicals with high bioactivity and novel action mechanism may be a feasible strategy to control intractable bacterial diseases. As a privileged molecular framework, steroid molecules exhibit diversiform bioactivities.

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Plant bacterial diseases can potentially damage agricultural products around the world, and few effective bactericides can manage these infections. Herein, to sequentially explore highly effective antibacterial alternatives, 1,2,3-triazole-tailored carbazoles were rationally fabricated. These compounds could suppress the growth of three main intractable pathogens including pv (), pv (), and pv () with lower EC values of 3.

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In recent years, naturally occurring tetrahydro-β-carboline (THC) alkaloids and their derivatives have been of biological interest. However, few studies and developments have reported the use of such structures in managing plant bacterial diseases. Herein, an array of novel THC derivatives containing an attractive 1,3-diaminopropan-2-ol pattern were prepared to evaluate the antiphytopathogen activity and and explore innovative antibacterial frameworks.

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Background: Induced apoptosis is an effective technique that can reprogram cellular physiological and pathological processes to eradicate undesirable cells using their innate systems. Inspired by this, numerous apoptosis inducers have been developed to treat animal diseases, especially in the anticancer field. However, few studies have reported on the development of inductive agents that attack plant pathogens by activation of apoptosis.

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