Publications by authors named "Hong-Wen Zhu"
Article Synopsis
- The study evaluates the clinical importance of methylation levels of DDR1 and CtBP genes in assessing the severity of acute pancreatitis (AP) using blood samples from both patients and healthy individuals.
- Key findings showed that the methylation level of the CtBP1 gene and the MCTSI score were independent predictors of severe acute pancreatitis (SAP), with high accuracy values.
- The research suggests that while CtBP1 methylation is a reliable predictor of SAP, the methylation levels of DDR1, SPINK1, CtBP2, and CFTR genes also have potential in identifying acute pancreatitis cases.
Article Synopsis
- The study aimed to assess the risks of bisphosphonates and their effects on femoral fracture healing in an osteoporosis model, specifically examining the impact of risedronate on recovery time and bone integrity.
- Methods included ovariectomy surgery to simulate osteoporosis, followed by femoral fracture surgery and risedronate or saline treatments, analyzed through X-ray and tissue examination for various bone parameters over several weeks.
- Results indicated that risedronate initially enhanced fracture healing and bone density within the first three weeks but caused delayed healing in the subsequent three weeks, highlighting the complex effects of bisphosphonates on fracture recovery.
Staphylococcus epidermidis is a common causative of nosocomial infections associated with indwelling medical devices. To date, the mechanisms of the pathogenicity and drug resistance of S. epidermidis have not been clearly elucidated.
View Article and Find Full Text PDFBackground & Aims: The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and developing immunotherapy.
Methods: We combined whole-exome/transcriptome sequencing, multiplex immunostaining, immunopeptidomes, T cell receptor (TCR) sequencing and bioinformatic analyses of 47 tumors from 15 patients with HCC and multifocal lesions.
Background: Wilson's disease is an autosomal recessive disorder characterized by liver disease and/or neurologic deficits due to copper accumulation and is caused by pathogenic mutations in the ATP7B gene.
Data Sources: Two unrelated Chinese patients born to nonconsanguineous parents who were diagnosed with earlyonset Wilson's disease. DNA sequencing and bioinformation analysis were conducted.
Article Synopsis
- Esophageal squamous cell carcinoma (ESCC) is the most prevalent form of esophageal cancer and a major cause of cancer-related deaths globally, with a focus on the role of DDX46, a DEAD-box RNA helicase, in its progression.
- The study measured DDX46 levels in ESCC and normal tissues using various techniques, finding that DDX46 was significantly higher in cancerous cells; silencing DDX46 in ESCC cell lines led to reduced cell growth and increased apoptosis.
- Results indicated that DDX46 promotes ESCC cell proliferation through modulation of Akt, IκBα, and NF-κB signaling pathways, suggesting it may serve as a potential biomarker and therapeutic target for ESCC
[Mutation analysis of phenylalanine hydroxylase gene in 55 patients with phenylketonuria from Hebei province].
Zhonghua Yi Xue Za Zhi
November 2011
Article Synopsis
- The study aimed to identify pathogenic mutations in the phenylalanine hydroxylase gene (PAH) among phenylketonuria (PKU) patients in Hebei Province.
- Researchers analyzed genomic DNA from 55 patients using PCR and other techniques, discovering 108 mutant alleles affecting various PAH exons.
- A total of 41 different mutations were identified, with many being single nucleotide substitutions; some novel mutations and a notable prevalence of specific common mutations were also reported.
[Effect of extract of ginkgo bilboa leaf on early diabetic nephropathy].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2005
Article Synopsis
- - The study aimed to assess the effects of Ginkgo biloba leaf extract (EGB) on kidney damage in patients with early diabetic nephropathy (DN).
- - A total of 68 early DN patients were split into two groups: one received standard treatment plus EGB, while the other only received standard treatment for three months.
- - Results showed that the group taking EGB had significant reductions in various harmful indicators of kidney function post-treatment, indicating EGB may protect against early DN.