Interaction between microRNA expression and classical risk factors in the risk of coronary heart disease.

The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesions in subjects with CHD. Plasma samples were obtained from 66 subjects with CHD and from 58 control individuals. A quantitative reverse-transcription PCR (RT-qPCR) assay was conducted to confirm the relative expressions of the known CHD-related miRNAs.

Hemoglobin A1c risk score for the prediction of coronary artery disease in subjects with angiographically diagnosed coronary atherosclerosis.

Objective: To develop a risk score by incorporating Hemoglobin A1c(HbA1c) with traditional risk factors for the prediction of coronary artery disease (CAD) in Chinese subjects.

Methods: A total of 196 consecutive subjects (131 males and 65 females) aged 38-89 years who underwent coronary angiography were enrolled in this study. HbA1c risk score sheets for the prediction of CAD were developed using age, gender and HbA1c.

Reduced difference in left ventricular mass at end diastole and peak systole is a predictor of major stenosis of the left coronary artery territory.

Objectives: To evaluate the feasibility of using the difference in left ventricular (LV) mass at end diastole and peak systole as determined by area-length calculation methods to detect major stenosis of the left coronary artery territory by 2-dimensional echocardiography.

Methods: The LV mass at end diastole, LV mass at peak systole, and LV mass difference between end diastole and peak systole were measured and compared between 39 healthy participants and 40 patients with coronary artery disease (CAD) referred for coronary angiography. The mass difference was compared to the mean percent stenosis diameter by linear correlation analysis, and its performance in discrimination between the patients with CAD and the healthy participants was analyzed.

Coalition of DNA polymorphisms of ApoB and ApoAI genes is related with coronary artery disease in Kazaks.

Objective: To explore the relationship between polymorphisms of XbaI and MspI loci of apolipoprotein B (ApoB) gene and -75 bp, +83 bp loci of apolipoprotein AI (ApoAI) gene and coronary heart disease (CHD) in Kazaks of Xinjiang Uyghur Autonomous Region, China.

Methods: These loci were analyzed by PCR-restriction fragment length polymorphism (PCR-PFLP). Two hundred and five patients with CHD and two hundred and thirty six controls were involved.

Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors: a multi-ethnic study.

Objective: The objective of the present multi-ethnic study was to explore whether an association exists between brachial-ankle pulse wave velocity (baPWV) and cardiovascular risk factors in China.

Methods: Two hundred sixty-four adult subjects (152 subjects were of Han nationality, 70 subjects were from Uygur, 19 subjects were from Kazakh, 15 subjects were from Hui, and 8 subjects were of other nationalities.) aged 30-82 years were enrolled in the present study.

A novel approach to assessing changes in prostate stiffness with age using virtual touch tissue quantification.

Objectives: Virtual touch tissue quantification is a promising new implementation of the acoustic radiation force impulse ultrasound technique. The purposes of this study were to describe the normal shear wave velocity values of the prostate by virtual touch tissue quantification and to examine the clinical usefulness of this procedure in evaluation of age-related shear wave velocity changes in the prostate.

Methods: One hundred twenty healthy volunteers were involved in this study.