Combination of mulberry leaf active components possessed synergetic effect on SD rats with diabetic nephropathy by mediating metabolism, Wnt/β-catenin and TGF-β/Smads signaling pathway.

Ethnopharmacological Relevance: Mulberry leaf has attracted much attention due to its excellent curative effect on diabetes and its complications, whether the combination of its effective components have protective and synergistic effect on diabetic nephropathy (DN) in vivo remain unclear.

Aim Of The Study: The aim of this study was to investigate the protective and synergistic effect of the combination (MAF and MAF) of mulberry leaf alkaloids (MA) and flavonoids extract (MF) on DN.

Materials And Methods: A step by step method consisted of network pharmacological prediction, animal in vivo validation and metabolic mechanism research was used to construct the multi-component-target-pathway network of mulberry leaf against DN.

[Study on improvement and mechanism of tableting properties of porous Fagopyri Dibotryis Rhizoma powders].

At present, there are many difficulties in the development and production of traditional Chinese medicine(TCM) tablets. This work aimed to explore the feasibility of improving dissolution difficulty and large dosage of TCM tablets by co-spray drying TCM extract with a small amount of pore-foaming agent ammonium bicarbonate. A series of porous Fagopyri Dibotryis Rhizoma powders were prepared by co-spray drying Fagopyri Dibotryis Rhizoma with different amounts of ammonium bicarbonate, and their powder pro-perties and tablet properties were comparatively investigated.

[Scaled-up production and application of co-processed excipient mannitol-HPMC in traditional Chinese medicine].

Spray drying technology was used to produce co-processed excipients mannitol- hydroxypropyl methylcellulose (HPMC), and study the scaled-up production. The consistency of powder and tablet properties before and after scale-up of co-processed excipients was compared, and their applicability in traditional Chinese medicine (TCM) powder's direct compression was tested on five TCM extracts such as gardenia extract and Radix Paeoniae Alba extract. It was shown that after scaled-up production, the key properties of co-processed excipients had little changes (such as compactability, disintegrating time, and lubrication sensitivity) or improvement (such as flowability and yield).

Optimization of Microwave-assisted Extraction of Silymarin from Straws by Response Surface Methodology and Quantification by High-Performance Liquid Chromatograph Method.

Background: , a member of the Aster family, is a well-known Chinese herb and the source of a popular antioxidant that is extensively used in Asia. The abundant straws are still underutilized and wastefully discarded to pollute the environment.

Objective: To solve the above problem and better utilize straws, the objective of this study was to optimize the conditions for extraction of silymarin from straws.